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Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE
CONCLUSIONS: In patients with atherosclerotic cardiovascular disease, long-term achievement of lower LDL-C levels, down to <20 mg/dL (<0.5 mmol/L), was associated with a lower risk of cardiovascular outcomes with no significant safety concerns.REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT01764633.PMID:36779348 | DOI:10.1161/CIRCULATIONAHA.122.063399
Source: Atherosclerosis - February 13, 2023 Category: Cardiology Authors: Prakriti Gaba Michelle L O'Donoghue Jeong-Gun Park Stephen D Wiviott Dan Atar Julia F Kuder KyungAh Im Sabina A Murphy Gaetano M De Ferrari Zbigniew A Gaciong Kalman Toth Ioanna Gouni-Berthold Jose Lopez-Miranda Fran çois Schiele Fran çois Mach Jose H F Source Type: research

Similarities and differences in systemic risk factors for retinal artery occlusion and retinal vein occlusion: A nationwide case-control study
CONCLUSION: Differences in the level of associations with the included risk factors suggests differences in the pathophysiologies of the two diseases. The main pathophysiology associated with RAO was atherosclerosis, whereas the main pathophysiology associated with RVO was changes in the pressure gradients of the eyes.PMID:36056288 | DOI:10.1007/s10792-022-02483-3
Source: Atherosclerosis - September 2, 2022 Category: Cardiology Authors: Marie Ørskov Henrik Vorum Torben Bjerregaard Larsen Gregory Y H Lip Toke Bek Flemming Skj øth Source Type: research

Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review
Crit Rev Food Sci Nutr. 2022 Jun 16:1-66. doi: 10.1080/10408398.2022.2084600. Online ahead of print.ABSTRACTAge-related diseases are associated with increased morbidity in the past few decades and the cost associated with the treatment of these age-related diseases exerts a substantial impact on social and health care expenditure. Anti-aging strategies aim to mitigate, delay and reverse aging-associated diseases, thereby improving quality of life and reducing the burden of age-related pathologies. The natural dietary antioxidant supplementation offers substantial pharmacological and therapeutic effects against various dise...
Source: Atherosclerosis - June 16, 2022 Category: Cardiology Authors: Phaniendra Alugoju V K D Krishna Swamy Naga Venkata Anusha Anthikapalli Tewin Tencomnao Source Type: research

Clinical risk factors for retinal artery occlusions: a nationwide case-control study
CONCLUSION: The investigated risk factors suggest that atherosclerosis and conditions changing the intraocular pressure are involved in the pathophysiology of RAO.PMID:35305540 | DOI:10.1007/s10792-022-02247-z
Source: Atherosclerosis - March 19, 2022 Category: Cardiology Authors: Marie Ørskov Henrik Vorum Torben Bjerregaard Larsen Gregory Y H Lip Toke Bek Flemming Skj øth Source Type: research

Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke Original Articles
Conclusions: This result represents the first genetic evidence in a large cohort for the protective effect of PCSK9 inhibition on ischemic stroke and corroborates exploratory evidence from clinical trials. PCSK9 inhibition was not associated with variables other than those related to LDL (low-density lipoprotein) cholesterol, atherosclerosis, and type 2 diabetes mellitus, suggesting that other effects are either small or absent.
Source: Circulation: Cardiovascular Genetics - July 11, 2018 Category: Cardiology Authors: Rao, A. S., Lindholm, D., Rivas, M. A., Knowles, J. W., Montgomery, S. B., Ingelsson, E. Tags: Cardiovascular Disease, Diabetes, Type 2, Genetic, Association Studies, Ischemic Stroke Original Articles Source Type: research

Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract
ConclusionLong-term statin treatment is remarkably safe with a low risk of clinically relevant adverse effects as defined above; statin-associated muscle symptoms were discussed in a previous Consensus Statement. Importantly, the established cardiovascular benefits of statin therapy far outweigh the risk of adverse effects.
Source: European Heart Journal - April 27, 2018 Category: Cardiology Source Type: research