Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract
ConclusionLong-term statin treatment is remarkably safe with a low risk of clinically relevant adverse effects as defined above; statin-associated muscle symptoms were discussed in a previous Consensus Statement. Importantly, the established cardiovascular benefits of statin therapy far outweigh the risk of adverse effects.
ConclusionPanel ‐based targeted exome sequencing revealed 23 novel mutations, recognized different combinations forms of variants, and extended the mutational spectrum of retinitis pigmentosa and depicted common variants in northeast China.
ConclusionOur analysis provided strong evidence to indicate a causal relationship between WC and increased risk of CHD.
Publication date: Available online 27 February 2020Source: The American Journal of SurgeryAuthor(s): Lawrence A. Lavery, Kathryn E. Davis, Javier La Fontaine, J. David Farrar, Kavita Bhavan, Orhan K. Oz, Peter A. Crisologo
The objective of this study was to examine the effect of metabolic syndrome on 30-day postoperative complications following corrective surgery for the adult spinal deformity (ASD). Summary of Background Data: Metabolic syndrome has been shown to increase the risk of cardiovascular morbidity and mortality. Few studies have examined the effect of metabolic syndrome on patients with ASD undergoing surgery. Materials and Methods: We performed a retrospective cohort study of patients who underwent spinal fusion for ASD. Patients were divided into 2 groups based on the presence or absence of metabolic syndrome, which was d...
Publication date: Available online 26 February 2020Source: Journal of Advanced ResearchAuthor(s): Heng Zhang, Yaqian Huang, Selena Chen, Chaoshu Tang, Guang Wang, Junbao Du, Hongfang Jin
Conditions: Diabetes Mellitus; Cardiovascular Diseases Interventions: Drug: Renin-angiotensin-aldosterone system inhibitors; Drug: Beta blocker; Drug: SGLT2 Inhibitor - Sodium Glucose Cotransporter Subtype 2 Inhibitor Product Sponsors: National Heart Centre Singapore; Singapore General Hospital; Mackay Memorial Hospital; National Taiwan University Hospital; Peking University People's Hospital; Medanta, The Medicity, India; Public Health&...
Condition: Epilepsy Intractable Intervention: Other: Direct electrical stimulation Sponsors: University of Pennsylvania; National Institute of Neurological Disorders and Stroke (NINDS); Columbia University; Dartmouth College; Emory University; University of Freiburg; Thomas Jefferson University; University of Texas Southwestern Medical Center; Natio nal Institute on Aging (NIA) Recruiting
Conditions: Diabetes Mellitus, Type 2; Diabetes; Diabetes type2; Type2 Diabetes; Type 2 Diabetes; Type II Diabetes; Hypertension; High Blood Pressure Interventions: Other: DASH4D diet; Other: comparison diet; Other: higher sodium; Other: lower sodium Sponsors: Johns Hopkins University; Beth Israel Deaconess Medical Center Not yet recruiting
Condition: Pre-Diabetic Interventions: Drug: Calcitriol capsules; Drug: Oral Placebo Sponsor: Mayo Clinic Not yet recruiting
Conditions: Stroke; Brain Disease; Central Nervous System Diseases; Nervous System Diseases; Cardiovascular Diseases Intervention: Device: Transcranial Magnetic Stimulation Sponsors: VA Pittsburgh Healthcare System; University of Pittsburgh Recruiting