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Signaling Pathways Associated with Prior Cardiovascular Events in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common genetic cardiomyopathy. A subset of patients experience major adverse cardiovascular event (MACE) including arrhythmias, stroke, and heart failure. However, molecular mechanisms underlying MACE in HCM are still not well understood. We therefore conducted a multicenter case-control study of patients with HCM comparing those with and without prior history of MACE to identify dysregulated signaling pathways through plasma proteomics profiling.
Source: Journal of Cardiac Failure - August 7, 2023 Category: Cardiology Authors: Charlotte Lee, Lusha W. Liang, Kohei Hasegawa, Mathew S. Maurer, Albree Tower-Rader, Michael A. Fifer, Muredach Reilly, Yuichi J. Shimada Source Type: research

Tafamidis Reduces The Decline In Longitudinal Strain And Stroke Volume In Patients With Transthyretin Amyloid Cardiomyopathy
Left ventricular (LV) longitudinal strain and stroke volume are significant predictors of mortality in patients with transthyretin amyloid cardiomyopathy (ATTR-CM). In the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT), tafamidis significantly reduced mortality and CV-related hospitalizations. Further analysis of changes in echocardiographic measures in ATTR-ACT may provide additional insight into the efficacy of tafamidis.
Source: Journal of Cardiac Failure - April 1, 2022 Category: Cardiology Authors: Perry Elliott, Allan L. Klein, Fabio Fernandes, Balarama Gundapaneni, Marla B. Sultan, Sanjiv J. Shah Tags: 256 Source Type: research

Myocardial Contraction Fraction Predicts Cardiovascular Events in Patients with Hypertrophic Cardiomyopathy and Normal Ejection Fraction
Left ventricular ejection fraction (LVEF) is a commonly used index of systolic function. However, the LVEF often remains normal in patients with hypertrophic cardiomyopathy (HCM) despite disease progression until the end-stage of the disease. This is because myocardial hypertrophy results in progressive declines in ventricular capacitance and end-diastolic volume, which are accompanied by reduction in stroke volume.1-5 Accordingly, the LVEF does not correlate with functional capacity in HCM6 and is not predictive of adverse events including worsening heart failure, arrhythmias, sudden death, or appropriate implantable card...
Source: Journal of Cardiac Failure - March 26, 2019 Category: Cardiology Authors: Yuichi J. Shimada, Christopher W. Hoeger, Farhana Latif, Hiroo Takayama, Jonathan Ginns, Mathew S. Maurer Tags: Clinical Investigation Source Type: research

Morphosis of Multi-Layered Mitochondria in the Myocardium of a Patient With Mitochondrial Cardiomyopathy Revealed by Electron Microscopy
A 35-year-old woman, who had been diagnosed as mitochondrial myopathy, encephalopathy, lactic acidosis, stroke-like episodes (MELAS) 10 years before, was referred for the evaluation of mitochondrial cardiomyopathy at the first onset of a stroke-like episode. The echocardiogram showed nearly normal systolic function. HE staining of the tissue obtained by endomyocardial biopsy showed marked vacuolization especially at the perinuclear region. Electron microscopy demonstrated damaged myofibril and severe abnormalities of the mitochondria such as giant mitochondrion, crescent-like mitochondria, and multi-layered mitochondria as...
Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Masataka Ikeda, Tomomi Ide, Takeo Fujino, Kisho Ohtani, Taiki Higo, Hiroyuki Tsutsui Source Type: research

Super High Dose Beta-blocker Administration for the Patients with Dilated Cardiomyopathy
First case is a 25-year-old female with dilated cardiomyopathy. Left ventricular end-diastolic diameter (LVEDD) was 74  mm and ejection fraction (EF) was 29%. Carvedilol was already uptitrated to 20 mg twice daily. Right heart catheterization (RHC) revealed very low cardiac output (C.O. 2.82 l/min), cardiac index (C.I. 1.47 l/min/m2), stroke volume (SV 29 ml) and rapid heart rate (HR 96/min) despite maximu m dosage of carvedilol in Japan. Carvedilol was uptitrated to 50 mg twice daily and additional 10 mg bisoprolol twice daily was started under administration of low-dose dobutamine.
Source: Journal of Cardiac Failure - September 20, 2017 Category: Cardiology Authors: Akihiro Isotani, Takashi Morinaga, Shintaro Mori, Shinya Ito, Makoto Hyodo, Shinichi Shirai, Kenji Ando Source Type: research

Patients Selection for Left Ventriculoplasty and Mitral Valve Surgery in Non-Ischemic Dilated Cardiomyopathy
The operative indication for dilated cardiomyopathy (DCM) is controversial. Subjects were 20 non-ischemic DCM patients. Left ventriculoplasty and mitral valve repair were conducted. Cardiac index derived from forward stroke volume significantly increased after surgery (from 1.8  ± 0.6 to 2.4 ± 0.6, P = .001). One-year survival rate was 58%. Slope in preload recruitable stroke work relationship (Mw) was an independent predictor for survival after surgery (HR, 0.936; 95%CI, 0.894–0.980; P = .005). Cut-off value of Mw for one-year survival was 42.
Source: Journal of Cardiac Failure - August 24, 2016 Category: Cardiology Authors: Yasushige Shingu, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui Source Type: research

Focal Decrease in Cardiac 123I-Meta-Iodobenzylguanidine Uptake in Patients with Anderson-Fabry Disease
Backgraound: Anderson-Fabry disease(AFD)is an X-linked storage disease characterized by multi-organ involvement and premature death attributable to cardiac failure, stroke and renal failure. Fabry cardiomyopathy is frequent and leads to concentric left ventricular hypertrophy.Typical pattern in advanced stages is myocardial replacement fibrosis,first localized to mid myocardial layers of basal infero-lateral myocardium and then resulting in transmural fibrosis.We investigated cardiac sympathetic nervous function in patients with AFD.
Source: Journal of Cardiac Failure - August 24, 2016 Category: Cardiology Authors: Saori Yamamoto, Hideaki Suzuki, Koichiro Sugimura, Syunsuke Tatebe, Tatsuo Aoki, Masanobu Miura, Nobuhiro Yaoita, Kentaro Takanami, Kei Takase, Hiroaki Shimokawa Source Type: research

Stoke Work Index Predicts Left Ventricular Reverse Remodeling
To examine whether left ventricular stroke work index (LVSWI) predicts LV reverse remodeling after surgery for patients with ischemic dilated cardiomyopathy.
Source: Journal of Cardiac Failure - September 25, 2015 Category: Cardiology Authors: Yasushige Shingu, Satoru Wakasa, Tomonori Ooka, Tsuyoshi Tachibana, Yoshiro Matsui Source Type: research

Chagas Cardiomyopathy is Associated With Higher Incidence of Stroke: A Meta-analysis of Observational Studies
Chagas disease (CD) has been associated with an elevated risk of stroke, but current data are conflicting and prospective controlled studies are lacking. We performed a systematic review and meta-analysis examining the association between stroke and CD.
Source: Journal of Cardiac Failure - September 14, 2014 Category: Cardiology Authors: Rhanderson N. Cardoso, Francisco Yuri B. Macedo, Melissa Nolan Garcia, Daniel C. Garcia, Alexandre M. Benjo, David Aguilar, Hani Jneid, Biykem Bozkurt Tags: Clinical Investigation Source Type: research

Chagas’ cardiomyopathy is associated with higher incidence of stroke: a meta-analysis of observational studies
Chagas’ disease (CD) has been associated with an elevated risk of stroke, but current data are conflicting and prospective controlled studies are lacking. We performed a systematic review and meta-analysis examining the association between stroke and CD.
Source: Journal of Cardiac Failure - September 14, 2014 Category: Cardiology Authors: Rhanderson N. Cardoso, Francisco Yuri B. Macedo, Melissa Nolan Garcia, Daniel C. Garcia, Alexandre M. Benjo, David Aguilar, Hani Jneid, Biykem Bozkurt Tags: Clinical Investigations Source Type: research

Noninvasive Monitoring of Stroke Volume With Resynchronization Devices in Patients With Ischemic Cardiomyopathy
Conclusions: In CRT patients with chronic infarction and wall motion abnormalities, impedance is a valid parameter to estimate stroke volume and to guide optimization of CRT timing.
Source: Journal of Cardiac Failure - August 1, 2013 Category: Cardiology Authors: Michael Kühne, Mario Bocchiardo, Herbert Nägele, Beat Schaer, Michael Lippert, Christian Sticherling, Stefan Osswald Tags: Clinical Investigations Source Type: research