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Age-Dependence of Flow Homeostasis in the Left Ventricle
Conclusions: In average, blood spends 1 to 3 beats inside the LV with very low shear stress rates. The apical region is the most prone to blood stasis, particularly in mid-aged adults. The washout of blood in the normal LV is age-dependent due to physiological changes in the degree of apical penetration of the filling waves. Introduction Cardioembolic stroke is a major source of mortality and disability worldwide and blood stasis one of its major determinants (Adams et al., 1986). Left ventricular (LV) function has evolved to maximize mechanical efficiency and ensure organ perfusion at a low cost of energy and fill...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Cardiac Responses to Left Ventricular Pacing in Hearts with Normal Electrical Conduction: Beneficial Effect of Improved Filling is Counteracted by Dyssynchrony.
In conclusion, pacing of the LV lateral wall increased LVEDV by displacing the septum rightwards, suggesting a mechanism for a favorable effect of CRT in narrow QRS. The pacing, however, induced dyssynchrony and therefore reduced LV systolic function. These observations suggest that detrimental effects should be considered when applying CRT in patients with narrow QRS. PMID: 24906920 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - June 6, 2014 Category: Physiology Authors: Boe E, Russell K, Remme EW, Gjesdal O, Smiseth OA, Skulstad H Tags: Am J Physiol Heart Circ Physiol Source Type: research

Mechano-electrical coupling as framework for understanding functional remodeling during LBBB and CRT.
In conclusion, MEC may represent a useful framework for better understanding the long-term changes in cardiac electrophysiology and contraction following LBBB as well as CRT. PMID: 24748591 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Heart and Circulatory Physiology - April 18, 2014 Category: Physiology Authors: Kuijpers NH, Hermeling E, Lumens J, Eikelder HT, Delhaas T, Prinzen FW Tags: Am J Physiol Heart Circ Physiol Source Type: research