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Haematoloechus sp. attachment shifts endothelium in vivo from pro- to anti-inflammatory profile in Rana pipiens: evidence from systemic and capillary physiology
Am J Physiol Regul Integr Comp Physiol. 2023 Jun 5. doi: 10.1152/ajpregu.00041.2023. Online ahead of print.ABSTRACTThis prospective, descriptive study focused on lung flukes (Haematoloechus sp., H) and their impact on systemic and individual capillary variables measured in pithed Rana pipiens, a long-standing model for studies of capillary physiology. Three groups were identified based on H attachment: no Haematoloechus (No H), Haematoloechus not attached (H Not Att), and Haematoloechus attached (H Att). Among 38 descriptive, cardiovascular, and immunological variables, 18 changed significantly with H. Symptoms of H includ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - June 5, 2023 Category: Physiology Authors: Donna A Williams Mary H Flood Source Type: research

Amino acid solution mitigates hypothermia response and intestinal damage following exertional heat stroke in male mice
Exertional heat stroke (EHS) is a debilitating and potentially fatal condition for which few prevention strategies exist. These results suggest that a 5AAS improves Tc regulation during EHS recovery through maintaining mucosal function and integrity and that protecting the GI tract during EHS may be beneficial in some of the health consequences of EHS exposure. AbstractIncreased gut permeability is implicated in the initiation and extent of the cytokine inflammatory response associated with exertional heat stroke (EHS). The primary objective of this study was to determine if a five amino acid oral rehydration solution (5AA...
Source: Physiological Reports - May 23, 2023 Category: Physiology Authors: Michelle A. King, Astrid Grosche, Shauna M. Ward, Jermaine A. Ward, Anusree Sasidharan, Thomas A. Mayer, Mark L. Plamper, Xiaodong Xu, Matthew D. Ward, Thomas L. Clanton, Sadasivan Vidyasagar Tags: ORIGINAL ARTICLE Source Type: research

The effect of obesity, hypertension, diabetes mellitus, alcohol, and sleep apnea on the risk of atrial fibrillation
Physiol Res. 2021 Dec 30;70(Suppl4):S511-S525.ABSTRACTAtrial fibrillation (AF) is the most common sustained cardiac arrhythmia associated with a two-fold increase in mortality caused by a higher risk of stroke and heart failure. Currently, AF is present in ~ 2 % of the general population, and its incidence and prevalence are increasing. Obesity, hypertension, diabetes mellitus, obstructive sleep apnea, and alcohol consumption increase the risk of AF. Each unit of increase in BMI increases the risk of AF by 3 %, and intensive weight loss is also associated with reduced AF recurrence. Hypertension increases the risk of AF by...
Source: Physiological Research - February 24, 2022 Category: Physiology Authors: Z Čarná P Osman čík Source Type: research

Improved cardiac function and dietary fatty acid metabolism after modest weight loss in subjects with impaired glucose tolerance.
Abstract Using a novel positron emission tomography (PET) method with oral administration of 14(R,S)-[(18)F]-fluoro-6-thia-heptadecanoic acid ((18)FTHA), we recently demonstrated that subjects with impaired glucose tolerance (IGT) display an impairment in cardiac function associated with increased myocardial uptake of dietary fatty acids. Here, we determined whether modest weight loss induced by lifestyle changes might improve these cardiac metabolic and functional abnormalities. Nine participants with IGT, enrolled in a one-year lifestyle intervention trial, were invited to undergo determination of organ-specific...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 22, 2014 Category: Physiology Authors: Labbé SM, Noll C, Grenier-Larouche T, Kunach M, Bouffard L, Phoenix S, Guérin B, Baillargeon JP, Langlois MF, Turcotte EE, Carpentier AC Tags: Am J Physiol Endocrinol Metab Source Type: research