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Locomotor muscle group III/IV afferents constrain stroke volume and contribute to exercise intolerance in human heart failure.
Conclusion These findings indicate that locomotor muscle group III/IV afferent feedback in patients with HFrEF leads to increased systemic vascular resistance, which constrains stroke volume, cardiac output, and O2 delivery thereby impairing V̇O2 peak and thus exercise capacity. These findings have important clinical implications as V̇O2 peak is highly predictive of morbidity and mortality in HF. This article is protected by copyright. All rights reserved. PMID: 32886795 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - September 3, 2020 Category: Physiology Authors: Smith JR, Joyner MJ, Curry TB, Borlaug BA, Keller-Ross ML, Van Iterson EH, Olson TP Tags: J Physiol Source Type: research

Intrathecal fentanyl abolishes the exaggerated blood pressure response to cycling in hypertensive men.
This study shows that attenuation of the exercise pressor reflex normalizes blood pressure response to cycling exercise in hypertensive individuals. This article is protected by copyright. All rights reserved. PMID: 26659384 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - December 12, 2015 Category: Physiology Authors: Barbosa TC, Vianna LC, Fernandes IA, Prodel E, Rocha HN, Garcia VP, Rocha NG, Secher NH, Nobrega AC Tags: J Physiol Source Type: research

Oscillatory blood pressure response to the onset of cycling exercise in men: Role of group iii/iv muscle afferents
This article is protected by copyright. All rights reserved
Source: Experimental Physiology - January 9, 2015 Category: Physiology Authors: Thales C. Barbosa, Igor A. Fernandes, Nisval Magalhães‐Jr, Ismar L. Cavalcanti, Niels H. Secher, Antonio C. L. Nobrega, Lauro C. Vianna Tags: Research Paper Source Type: research