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A new era of macrophage-based cell therapy
Experimental & Molecular Medicine, Published online: 01 September 2023; doi:10.1038/s12276-023-01068-zTreating disease with the white blood cells called macrophages, in some cases genetically modified, could become an effective clinical option for a range of diseases. Macrophages are cells of the innate (non-specific) immune system that can destroy diseased cells or damaging materials. They can also enhance tissue repair by releasing growth factors and anti-inflammatory molecules. Seung Hyeok Seok and colleagues at Seoul National University in South Korea review the laboratory research and clinical trials that are inve...
Source: Experimental and Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Yi Rang Na Sang Wha Kim Seung Hyeok Seok Source Type: research

ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulation
Experimental & Molecular Medicine, Published online: 13 February 2023; doi:10.1038/s12276-023-00937-xTreatment with a protein that stabilizes existing plaques within blood vessels could help reduce the risk of future cardiovascular events in patients with atherosclerosis. These plaques arise in part from a change in the behavior of the muscle cells within the walls of the blood vessels, which leads to the accumulation of lipids and other biomolecules and creates conditions that can ultimately result in a heart attack or stroke. Researchers led by Youngkeun Ahn and Yong Sook Kim at Chonnam National University Hospital, ...
Source: Experimental and Molecular Medicine - February 13, 2023 Category: Molecular Biology Authors: Dong Im Cho Min Joo Ahn Hyang Hee Cho Meeyoung Cho Ju Hee Jun Bo Gyeong Kang Soo Yeon Lim Soo Ji Yoo Mi Ra Kim Hyung-Seok Kim Su-Jin Lee Le Thanh Dat Changho Lee Yong Sook Kim Youngkeun Ahn Source Type: research

Induction of Nanog in neural progenitor cells for adaptive regeneration of ischemic brain
Experimental & Molecular Medicine, Published online: 14 November 2022; doi:10.1038/s12276-022-00880-3The NANOG regulatory protein promotes neuronal regeneration by prompting the self-renewal of progenitor cells following a stroke due to blood vessel blockage (ischemic stroke). NANOG is involved in cellular plasticity and reprogramming, including the maintenance of pluripotent stem cells. Gyung-Ah Jung at the Catholic University of Korea in Seoul, South Korea, and co-workers have demonstrated that NANOG is also critical to the brain’s adaptive response to ischemic stroke. They found that NANOG is preferentially expres...
Source: Experimental and Molecular Medicine - November 14, 2022 Category: Molecular Biology Authors: Gyung-Ah Jung Jin-A Kim Hwan-Woo Park Hyemi Lee Mi-Sook Chang Kyung-Ok Cho Byeong-Wook Song Hyun-Ju Kim Yunhee Kim Kwon Il-Hoan Oh Source Type: research

60 Years of Achievements by KSNM in Neuroimaging Research
Nucl Med Mol Imaging. 2022 Feb;56(1):3-16. doi: 10.1007/s13139-021-00727-1. Epub 2022 Jan 15.ABSTRACTNuclear medicine neuroimaging is able to show functional and molecular biologic abnormalities in various neuropsychiatric diseases. Therefore, it has played important roles in the clinical diagnosis and in research on the normal and pathological states of the brain. More than 400 outstanding studies have been conducted by Korean researchers over the past 60 years. In the 1990s, when multiheaded single-photon emission computed tomography (SPECT) scanners were first introduced in South Korea, stroke research using brain perfu...
Source: Molecular Medicine - February 21, 2022 Category: Molecular Biology Authors: Jae Seung Kim Hye Joo Son Minyoung Oh Dong Yun Lee Hae Won Kim Jungsu Oh Source Type: research