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Total 656 results found since Jan 2013.
Association between PDE4D polymorphism and ischemic stroke in young population
ConclusionWe found an association between SNP83 and the risk of IS in Chinese young population from northern Henan province. There was not a significant association between SNP87 and IS in Chinese young population.
Source: Saudi Journal of Biological Sciences - April 10, 2019 Category: Biology Source Type: research
Proteomic analyses identify a potential mechanism by which extracellular vesicles aggravate ischemic stroke
Publication date: Available online 7 June 2019Source: Life SciencesAuthor(s): Xintong Wang, Jiaoqi Wang, Xiaohua Shi, Chengliang Pan, Hongyu Liu, Yue Dong, Rui Dong, Jing Mang, Zhongxin XuAbstractAimsExtracellular vesicles (EVs) are vital for information exchange between donor and recipient cells. When cells are stressed (e.g., by oxygen glucose deprivation, OGD), the complex information carried by the EVs is altered by the donor cells. Here, we aimed to analyze the proteomic differences between EVs derived from OGD-damaged cells and EVs derived from undamaged cells to explore the potential mechanisms by which EVs aggravat...
Source: Life Sciences - June 7, 2019 Category: Biology Source Type: research
Scientists make a discovery that may explain some forms of stroke
(University of Sheffield) Scientists from the University of Sheffield have discovered a novel behaviour of the blood vessels of the brain in zebrafish that may explain some forms of stroke in humans.
Source: EurekAlert! - Biology - June 21, 2019 Category: Biology Source Type: news
New therapy promotes vascular repair following stroke
(University of Zurich) Following a stroke, antibodies that inhibit the signaling molecule Nogo-A can help repair blood vessels in the affected brain regions. This also promotes the regaining of motor functions, researchers at the University of Zurich have shown in a mouse model. The study opens up new avenues for treatment.
Source: EurekAlert! - Biology - June 24, 2019 Category: Biology Source Type: news
Neurotechnology holds promise for chronic stroke patients
(Wyss Center for Bio and Neuroengineering) Personalized neurotechnology-aided rehabilitation of the arm could improve recovery in severe chronic stroke patients according to a new paper published today in the journal Brain.
Source: EurekAlert! - Biology - June 30, 2019 Category: Biology Source Type: news
Glowing brain cells illuminate stroke recovery research
(Emory Health Sciences) A promising strategy for helping stroke patients recover, transplanting neural progenitor cells to restore lost functions, asks a lot of those cells. To help them to integrate into the brain, the cells get help from 'optochemogenetics.'
Source: EurekAlert! - Biology - July 1, 2019 Category: Biology Source Type: news
Gene expression profiling of humans under exertional heat stress: Comparisons between persons with and without exertional heat stroke
Publication date: Available online 25 September 2019Source: Journal of Thermal BiologyAuthor(s): Ming Qiang Ren, Josh B. Kazman, Preetha A. Abraham, Danit Atias-Varon, Yuval Heled, Patricia A. DeusterAbstractExertional heat stroke (EHS) is a leading cause of preventable morbidity and mortality among both athletes and warfighters. Therefore, it is important to find blood biomarkers to predict susceptibility to EHS. We compared gene expression profiling from blood cells between two groups of participants – those with and those without a history EHS – by using genome-wide microarray analysis. Subjects with a history of EH...
Source: Journal of Thermal Biology - September 26, 2019 Category: Biology Source Type: research
Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review
ConclusionsThis systematic review summarizes potential metabolic biomarkers and pathways related to IS, which may provide opportunities for the construction of diagnostic or predictive models for IS and the discovery of novel therapeutic targets.
Source: Metabolomics - November 20, 2019 Category: Biology Source Type: research
Virtual reality would make attending therapy easier for stroke survivors
(North Carolina State University) Researchers have created a virtual reality clinic to make it easier for stroke survivors to attend physical and occupational therapy sessions. Results from a proof-of-concept study suggest the technology -- and the social connection it facilitates -- are effective at encouraging therapy participation.
Source: EurekAlert! - Biology - November 22, 2019 Category: Biology Source Type: news
Sticky situation inside blood vessels can worsen stroke damage
(Medical College of Georgia at Augusta University) A stroke appears to create a sticky situation inside the blood vessels of the brain that can worsen damage days, even months later, scientists report.
Source: EurekAlert! - Biology - January 15, 2020 Category: Biology Source Type: news
Why is stroke so deadly for people of African descent?
(University of Virginia Health System) An international team of scientists has completed the largest analysis of stroke-risk genes ever undertaken in people of African descent.
Source: EurekAlert! - Biology - August 3, 2020 Category: Biology Source Type: news
Brain-Derived Neurotrophic Factor (BDNF) As a Regulator of Apoptosis under Conditions of Focal Experimental Stroke
The immunolocalization of apoptotic factors in rat neocortex was studied on the model of permanent occlusion of the middle cerebral artery with administration of exogenous BDNF. We revealed heterogeneous distribution of pro- and anti-apoptotic factors in the stroke area and in the surrounding penumbra, where caspase-3+ and p53+ cells were found. Their number was maximum on day 3 of ischemia. The number of neurons containing anti-apoptotic factors was relatively decreased. Injection of BDNF changed the distribution of apoptotic factors. In the penumbra area, BDNF enhanced the expression of Mdm2 primarily in the pyramid cell...
Source: Bulletin of Experimental Biology and Medicine - September 28, 2020 Category: Biology Source Type: research
Targeting calcium overload could improve stroke outcomes, research suggests
(University of Virginia Health System) Excessive calcium contributes to harmful inflammation in ischemic stroke, and targeting it may provide doctors with a new way to improve patient outcomes.
Source: EurekAlert! - Biology - November 23, 2020 Category: Biology Source Type: news
NYU Dentistry awarded $1.9M NIH grant to study mitochondrial changes behind stroke, heart attack
(New York University) The National Institute of General Medical Sciences, part of the National Institutes of Health (NIH), has awarded NYU College of Dentistry's Evgeny Pavlov a grant to study a phenomenon called mitochondrial permeability transition, one of the central causes of tissue damage during stroke and heart attack.
Source: EurekAlert! - Biology - February 1, 2021 Category: Biology Source Type: news
Microembolic Signals in Arteries of the Base of the Brain after Ischemic Stroke
Embolic strokes make up a significant proportion of acute cerebrovascular accidents. Doppler blood flow monitoring with microembolodetection allows suggesting the embolic nature of cerebral infarction. The aim of this study was to identify factors associated with the presence of microembolic signals in patients with ischemic stroke. The study included 515 patients, microembolic signals were detected in 48 (9.3%) of them. According to multispiral CT angiography, significant differences in patients with and without microembolic signals were found for wall thickness of both common carotid arteries and for left internal caroti...
Source: Bulletin of Experimental Biology and Medicine - June 23, 2022 Category: Biology Source Type: research
