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Specialty: Biology
Source: Redox Biology
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Total 20 results found since Jan 2013.
A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats: Role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation
Publication date: Available online 17 July 2020Source: Redox BiologyAuthor(s): Sha Liao, Jingni Wu, Ruimin Liu, Shixiang Wang, Jing Luo, Yang Yang, Yannan Qin, Tao Li, Xiaopu Zheng, Jing Song, Xinfeng Zhao, Chaoni Xiao, Yajun Zhang, Liujiao Bian, Pu Jia, Yajun Bai, Xiaohui Zheng
Source: Redox Biology - July 17, 2020 Category: Biology Source Type: research
Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function
Publication date: Available online 13 March 2020Source: Redox BiologyAuthor(s): Yongxing Lai, Peiqiang Lin, Manli Chen, Yixian Zhang, Jianhao Chen, Mouwei Zheng, Ji Liu, Houwei Du, Ronghua Chen, Xiaodong Pan, Nan Liu, Hongbin Chen
Source: Redox Biology - March 14, 2020 Category: Biology Source Type: research
α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury
ConclusionOverall, α-TOH inhibits ischemia/reperfusion injury-induced oxidative and inflammatory responses, and ultimately preserves cardiac function. Therefore, our study provides a strong incentive to test vitamin E as an acute therapy in patients suffering a MI.Graphical abstract
Source: Redox Biology - August 7, 2019 Category: Biology Source Type: research
Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy
Publication date: Available online 19 July 2019Source: Redox BiologyAuthor(s): Tawfeeq Shekh-Ahmad, Andreas Lieb, Stjepana Kovac, Lukas Gola, Christian W. Wigley, Andrey Y. Abramov, Matthew C. WalkerAbstractMany epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure, traumatic brain injury or stroke. The generation of reactive oxygen species (ROS) and induction of oxidative stress are common sequelae of such brain insults and have been shown to contribute to neuronal death and the development of epilepsy. Here, we show that combination therapy targeting the generation of ROS though ...
Source: Redox Biology - July 20, 2019 Category: Biology Source Type: research
Taurine and its analogs in neurological disorders: Focus on therapeutic potential and molecular mechanisms
This article also addresses the neuropharmacological potential of taurine analogs.Graphical abstract
Source: Redox Biology - May 22, 2019 Category: Biology Source Type: research
NRF2 and NF-қB interplay in Cerebrovascular and Neurodegenerative disorders: Molecular Mechanisms and Possible Therapeutic Approaches
Publication date: Available online 28 November 2018Source: Redox BiologyAuthor(s): Farzane Sivandzade, Shikha Prasad, Aditya Bhalerao, Luca CuculloAbstractElectrophiles and reactive oxygen species (ROS) play a major role in modulating cellular defense mechanisms as well as physiological functions, and intracellular signaling. However, excessive ROS generation (endogenous and exogenous) can create a state of redox imbalance leading to cellular and tissue damage 1. A growing body of research data strongly suggests that imbalanced ROS and electrophile overproduction are among the major prodromal factors in the onset and progr...
Source: Redox Biology - November 29, 2018 Category: Biology Source Type: research
Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway
In conclusion, enhanced BRCA1 after cerebral I/R injury may attenuate or prevent neural damage from I/R via NRF2-mediated antioxidant pathway. The finding may provide a potential therapeutic target against ischemic stroke.
Source: Redox Biology - July 11, 2018 Category: Biology Source Type: research
Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation
We report that IPC causes generation of endogenous lipid electrophiles, including 4-hydroxy-2-nonenal (4-HNE), which release Nrf2 from inhibition by Keap1 (via Keap1-C288) and inhibition by glycogen synthase kinase 3β (via GSK3β-C199). Nrf2 then induces expression of its target genes, including a new target, cadherin 5, a key component of adherens junctions of the BBB. These effects culminate in mitigation of BBB leakage and of neurological deficits after stroke. Collectively, these studies are the first to demonstrate that IPC protects the BBB against ischemic injury by generation of endogenous electrophiles and activat...
Source: Redox Biology - July 11, 2018 Category: Biology Source Type: research
Breast cancer susceptibility protein 1 (BRCA1) rescues neurons from cerebral ischemia/reperfusion injury through NRF2-mediated antioxidant pathway
In conclusion, enhanced BRCA1 after cerebral I/R injury may attenuate or prevent neural damage from I/R via NRF2-mediated antioxidant pathway. The finding may provide a potential therapeutic target against ischemic stroke.
Source: Redox Biology - July 7, 2018 Category: Biology Source Type: research
Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation
We report that IPC causes generation of endogenous lipid electrophiles, including 4-hydroxy-2-nonenal (4-HNE), which release Nrf2 from inhibition by Keap1 (via Keap1-C288) and inhibition by glycogen synthase kinase 3β (via GSK3β-C199). Nrf2 then induces expression of its target genes, including a new target, cadherin 5, a key component of adherens junctions of the BBB. These effects culminate in mitigation of BBB leakage and of neurological deficits after stroke. Collectively, these studies are the first to demonstrate that IPC protects the BBB against ischemic injury by generation of endogenous electrophiles and activat...
Source: Redox Biology - July 5, 2018 Category: Biology Source Type: research
Diverse roles of mitochondria in ischemic stroke
Publication date: June 2018 Source:Redox Biology, Volume 16 Author(s): Jenq-Lin Yang, Sujira Mukda, Shang-Der Chen Stroke is the leading cause of adult disability and mortality in most developing and developed countries. The current best practices for patients with acute ischemic stroke include intravenous tissue plasminogen activator and endovascular thrombectomy for large-vessel occlusion to improve clinical outcomes. However, only a limited portion of patients receive thrombolytic therapy or endovascular treatment because the therapeutic time window after ischemic stroke is narrow. To address the current shortage of st...
Source: Redox Biology - March 15, 2018 Category: Biology Source Type: research
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage
The objective of this study was to obtain evidence on whether TSAT determines the impact of experimental ischemic stroke on brain damage and whether iron-free transferrin (apotransferrin, ATf)-induced reduction of TSAT is neuroprotective. We found that experimental ischemic stroke promoted an early extravasation of circulating iron-loaded transferrin (holotransferrin, HTf) to the ischemic brain parenchyma. In vitro, HTf was found to boost ROS production and to be harmful to primary neuronal cultures exposed to oxygen and glucose deprivation. In stroked rats, whereas increasing TSAT with exogenous HTf was detrimental, admin...
Source: Redox Biology - December 14, 2017 Category: Biology Source Type: research
Neuroprotective effect of a new variant of Epo nonhematopoietic against oxidative stress
In conclusion, our results suggest that EpoL has a more potent neuroprotective profile than Epo against oxidative stress, mediated by activation of EpoR, thus EpoL represents an important target to develop a potential biopharmaceutical to treat different central nervous system pathologies related to oxidative stress such as stroke or neurodegenerative diseases.
Source: Redox Biology - October 4, 2017 Category: Biology Source Type: research
Sirt1-Sirt3 axis regulates human blood-brain barrier permeability in response to ischemia
In this study, we investigated the role of Sirt1-Sirt3 axis in blood-brain barrier (BBB) permeability after ischemia in vitro. Human brain microvascular endothelial cells and astrocytes were co-cultured to model the BBB in vitro and oxygen and glucose deprivation (OGD) was performed to mimic ischemia. The results of transepithelial electrical resistance (TEER) showed that suppression of Sirt1 via siRNA or salermide significantly decreased BBB permeability, whereas Sirt3 knockdown increased BBB permeability. In addition, Sirt1 was shown to regulate Sirt3 expression after OGD through inhibiting the AMPK-PGC1 pathway. Applica...
Source: Redox Biology - September 29, 2017 Category: Biology Source Type: research
