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Specialty: Biology
Source: Life Sciences
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Total 65 results found since Jan 2013.
Repurposing metformin to treat age-related neurodegenerative disorders and ischemic stroke
Publication date: Available online 11 March 2021Source: Life SciencesAuthor(s): Sejal Sharma, Saeideh Nozohouri, Bhuvaneshwar Vaidya, Thomas Abbruscato
Source: Life Sciences - March 11, 2021 Category: Biology Source Type: research
Donepezil in the treatment of ischemic stroke: Review and future perspective
Publication date: Available online 12 October 2020Source: Life SciencesAuthor(s): Arnavaz Hajizadeh Barfejani, Mahbod Jafarvand, Seyed Mohammad Seyedsaadat, Roozbeh Tarighati Rasekhi
Source: Life Sciences - October 13, 2020 Category: Biology Source Type: research
Advanced non-invasive MRI of neuroplasticity in ischemic stroke: Techniques and applications
Publication date: Available online 29 August 2020Source: Life SciencesAuthor(s): Chao Sun, Xuehuan Liu, Cuiping Bao, Feng Wei, Yi Gong, Yiming Li, Jun Liu
Source: Life Sciences - August 30, 2020 Category: Biology Source Type: research
Post-ischemic administration of dopamine D2 receptor agonist reduces cell death by activating mitochondrial pathway following ischemic stroke
Publication date: Available online 24 August 2020Source: Life SciencesAuthor(s): Pooja Kaushik, Mubashshir Ali, Heena Tabassum, Suhel Parvez
Source: Life Sciences - August 25, 2020 Category: Biology Source Type: research
Whole body hypothermia extends tissue plasminogen activator treatment window in the rat model of embolic stroke
Publication date: Available online 20 February 2020Source: Life SciencesAuthor(s): Mahsa Hassanipour, Mohammadreza Zarisfi, Vahid Ehsani, Mohammad AllahtavakoliAbstractLate treatment with tissue plasminogen activator (tPA) leads to reperfusion injury and poor outcome in ischemic stroke. We have recently shown the beneficial effects of local brain hypothermia after late thrombolysis. Herein, we investigated whether transient whole-body hypothermia was neuroprotective and could prevent the side effects of late tPA therapy at 5.5 h after embolic stroke. After induction of stroke, male rats were randomly assigned into four g...
Source: Life Sciences - February 20, 2020 Category: Biology Source Type: research
Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders
Publication date: Available online 8 January 2020Source: Life SciencesAuthor(s): Rohan Gupta, Rashmi K. Ambasta, Pravir KumarAbstractReversal of aging symptoms and related disorders are the challenging task where epigenetic is a crucial player that includes DNA methylation, histone modification; chromatin remodeling and regulation that are linked to the progression of various neurodegenerative disorders (NDDs). Overexpression of various histone deacetylase (HDACs) can activate Glycogen synthase kinase 3 which promotes the hyperphosphorylation of tau and inhibits its degradation. While HDAC is important for maintaining the ...
Source: Life Sciences - January 9, 2020 Category: Biology Source Type: research
Treadmill exercise improves neurological function by inhibiting autophagy and the binding of HMGB1 to Beclin1 in MCAO juvenile rats
Publication date: Available online 8 January 2020Source: Life SciencesAuthor(s): Guoyuan Pan, Lingqin Jin, Weimin Shen, Jieqiong Zhang, Juanjuan Pan, Jingyan Cheng, Qingfeng Xie, Quan Hu, Shamin Wu, Hongmei Zhang, Xiang ChenAbstractAimsTreadmill exercise is a beneficial treatment following childhood stroke. Thus, studies focusing on the neuroprotective mechanism of exercise training during postischemic treatment in children with ischemic stroke are urgently needed. We evaluated the effects of treadmill exercise on autophagy after cerebral ischemia in young rats.Main methodsRats (23–25 days old) underwent cerebral ische...
Source: Life Sciences - January 9, 2020 Category: Biology Source Type: research
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation
This study provides novel therapeutic targets and mechanisms for the treatment of ischemic stroke in the clinic, especially during cerebrovascular reperfusion.
Source: Life Sciences - November 6, 2019 Category: Biology Source Type: research
Dual-modality imaging of endothelial progenitor cells transplanted after ischaemic photothrombotic stroke
Publication date: Available online 2 November 2019Source: Life SciencesAuthor(s): Jie Ding, Yi Zhang, Cong-Xiao Wang, Pei-Cheng Li, Zhen Zhao, Chao Wang, Gao-Jun TengAbstractAimsStroke is a refractory cerebral blood circulation disorder. Endothelial progenitor cells (EPCs) participate in the repair and regeneration of vascular injury through the combination of cell replacement and bystander effects. Here, we evaluated the biological function of EPCs in treating a mouse model of cerebral ischaemic stroke, using dual-mode bioluminescence and magnetic resonance imaging to trace EPCs in vivo.Main methodsWe constructed a viral ...
Source: Life Sciences - November 4, 2019 Category: Biology Source Type: research
The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to endovascular thrombectomy
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Jenq-Lin Yang, Yun-Ru Yang, Shang-Der ChenAbstractStroke is the major cause of adult disability and the second or third leading cause of death in developed countries. The treatment options for stroke (thrombolysis or thrombectomy) are restricted to a small subset of patients with acute ischemic stroke because of the limited time for an efficacious response and the strict criteria applied to minimize the risk of cerebral hemorrhage. Attempts to develop new treatments, such as neuroprotectants, for acute ischemic stroke have been costly and tim...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research
β-Caryophyllene protects against ischemic stroke by promoting polarization of microglia toward M2 phenotype via the TLR4 pathway
The objective of the study was to determine whether β-caryophyllene (BCP) exerts a neuroprotective effect in cerebral ischemia-reperfusion (I/R) injury by inhibiting microglial activation and modulating their polarization via the TLR4 pathway.Main methodsWild-type (WT) and TLR4 knockout (KO) C57BL/6J mice were subjected to cerebral I/R injury and neurologic dysfunction, cerebral infarct volume, brain edema, microglia activation and polarization, and TLR4 expression were determined. In vitro, primary microglia were stimulated with LPS and IFN-γ or IL-4 to induce polarization of microglia toward M1 or M2 phenotypes.Key fin...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research
Ectopic TWEAKR expression in type I fiber of stroke-prone spontaneously hypertensive rats is related to slow muscle-specific hypotrophy
In this study, we aimed to investigate the pathophysiological characteristics of muscle hypotrophy in SHRSP to determine the therapeutic target molecule(s).Main methodsThe difference in skeletal muscles in the lower leg between WKY and SHRSP was evaluated mainly through weight/tibial length, histological, gene expression, and protein expression analyses.Key findingsSHRSP had a significantly lower weight/tibial length in soleus and gastrocnemius, but not in plantaris and tibialis anterior, indicating that muscles consisting of a relatively high amount of slow muscle fiber were affected. This result was confirmed by the hist...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research
A brain-stellate ganglion-atrium network regulates atrial fibrillation vulnerability through macrophages in acute stroke
Publication date: Available online 9 October 2019Source: Life SciencesAuthor(s): Youcheng Wang, Xiaoxing Xiong, Baojun Xie, Jia Liu, Mei Yang, Junkui Yin, Liuliu Zi, Xi Wang, Yanhong Tang, Congxin Huang, Haixia Fu, Qingyan ZhaoAbstractAimsNew-onset atrial fibrillation (AF) is frequently observed following acute stroke. The aim of this study was to investigate the effects of the brain-stellate ganglion-atrium network on AF vulnerability in a canine model with acute middle cerebral artery occlusion (MCAO).Materials and methodsTwenty-six dogs were randomly divided into the sham-operated group (n = 6), acute stroke (AS) gr...
Source: Life Sciences - October 10, 2019 Category: Biology Source Type: research
XQ-1H alleviates cerebral ischemia in mice through inhibition of apoptosis and promotion of neurogenesis in a Wnt/β-catenin signaling dependent way
Publication date: Available online 6 September 2019Source: Life SciencesAuthor(s): Dan Xu, Kai Hou, Fengyang Li, Shijie Chen, Weirong Fang, Yunman LiAbstractAims10-O-(N,N-dimethylaminoethyl)-ginkgolide B methanesulfonate (XQ-1H), a new derivative of ginkgolide B, has drawn great attention for its potent bioactivities against ischemia-induced injury. The purpose of this study was to further investigate the effect of XQ-1H against acute ischemic stroke by inducing middle cerebral artery occlusion/reperfusion (MCAO/R) injuries in mice.Main methodsTreatment of XQ-1H (78 or 39 mg/kg, i.g., bid) 2 h after MCAO improved motor...
Source: Life Sciences - September 7, 2019 Category: Biology Source Type: research
The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation
ConclusionCarvacrol provides protection for hippocampal neurons against I/R in gerbils by inhibiting ferroptosis through increasing the expression of GPx4.Graphical abstract
Source: Life Sciences - August 29, 2019 Category: Biology Source Type: research
