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Dexmedetomidine had neuroprotective effects on hippocampal neuronal cells via targeting lncRNA SHNG16 mediated microRNA-10b-5p/BDNF axis.
In conclusion, DEX exerts neuroprotective in ischemic stroke via improving neuron damage, the underlying mechanism may be upregulating SHNG16 and BDNF via sponging miR-10b-5p. PMID: 32323054 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - April 21, 2020 Category: Biochemistry Authors: Wang L, Liu W, Zhang Y, Hu Z, Guo H, Lv J, Du H Tags: Mol Cell Biochem Source Type: research

Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms
Publication date: Available online 16 January 2017 Source:Chemico-Biological Interactions Author(s): Xiaojing Lin, Cheng-Hsien Lin, Tingbao Zhao, Dan Zuo, Zhujun Ye, Lin Liu, Mao-Tsun Lin Heat stroke is characterilized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose of quercetin (30 mg/kg) or veh...
Source: Chemico Biological Interactions - January 16, 2017 Category: Biochemistry Source Type: research