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Specialty: Biochemistry
Drug: Estradiol
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Total 7 results found since Jan 2013.
Modulatory effect of 17β-estradiol on myeloid cell infiltration into the male rat brain after ischemic stroke
Publication date: Available online 11 May 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): M. Scheld, F. Heymann, W. Zhao, M. Tohidnezhad, T. Clarner, C. Beyer, A. Zendedel
Source: The Journal of Steroid Biochemistry and Molecular Biology - May 12, 2020 Category: Biochemistry Source Type: research
Impact of steroid hormones E2 and P on the NLRP3/ASC/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia
Publication date: Available online 15 May 2018Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Alexander Slowik, Leoni Lammerding, Adib Zendedel, Pardes Habib, Cordian BeyerAbstractClinical and animal model studies have demonstrated the neuroprotective and anti-inflammatory effects of 17beta-estradiol (E2) and progesterone (P) in different disease models of the central nervous system (CNS) including ischemic stroke. Inflammasomes are involved in the interleukin-1 beta (IL1beta) maturation, in particular, NLRP3, the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) an...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 11, 2018 Category: Biochemistry Source Type: research
Rutin attenuates cerebral ischemia/reperfusion injury in ovariectomized rats via estrogen receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
This study was performed to investigate whether rutin could protect against cerebral ischemia by modulating ER pathway. Ovariectomized (OVX) rats were given intraperitoneal injection of vehicle (DMSO), rutin (100 mg/kg) or 17β-estradiol (100 μg/kg) for 5 continuous days. Then, the rats were subjected to middle cerebral artery occlusion (MCAO) for 1 h followed by a 24-h reperfusion to establish the cerebral ischemia/reperfusion (I/R) injury. We found that rutin improved the sensorimotor performance and recognition memory of I/R rats, decreased the infarct size and attenuated the neuron loss. Rutin treatment also increased...
Source: Biochemistry and Cell Biology - February 8, 2018 Category: Biochemistry Authors: Liu H, Zhong L, Zhang Y, Liu X, Li J Tags: Biochem Cell Biol Source Type: research
Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: a comparative study with 17 β-estradiol
Publication date: Available online 4 May 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Teresa Jover-Mengual, María Castelló-Ruiz, María C. Burguete, María Jorques, Mikahela A. López-Morales, Alicia Aliena-Valero, Andrés Jurado-Rodríguez, Salvador Pérez, José M. Centeno, Francisco J. Miranda, Enrique Alborch, Germán Torregrosa, Juan B. Salom As the knowledge on the estrogenic system in the brain grows, the possibilities to modulate it in order to afford further neuroprotection in brain damaging disorders so do it. We have previously demonstrated the ability of the selective estr...
Source: The Journal of Steroid Biochemistry and Molecular Biology - May 5, 2017 Category: Biochemistry Source Type: research
What have we learned about GPER function in physiology and disease from knockout mice?
Publication date: Available online 16 July 2015 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Eric R. Prossnitz, Helen J. Hathaway Estrogens, predominantly 17β-estradiol, exert diverse effects throughout the body in both normal and patho-physiology, during development and in reproductive, metabolic, endocrine, cardiovascular, nervous, musculoskeletal and immune systems. Estrogen and its receptors also play important roles in carcinogenesis and therapy, particularly for breast cancer. In addition to the classical nuclear estrogen receptors (ERα and ERβ) that traditionally mediate predomi...
Source: The Journal of Steroid Biochemistry and Molecular Biology - July 17, 2015 Category: Biochemistry Source Type: research
