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Global Economic Burden Associated with Chronic Kidney Disease: A Pragmatic Review of Medical Costs for the Inside CKD Research Programme
CONCLUSION: Globally, CKD carries a significant economic burden, which increases substantially with increasing disease severity. We identified significant gaps in published costs and inconsistent costing definitions. Cost-effective interventions that target primary prevention and disease progression are essential to reduce CKD burden. Our results can be used to guide cost collection and facilitate better comparisons across countries/regions to inform healthcare policy.PMID:37493856 | DOI:10.1007/s12325-023-02608-9
Source: Adv Data - July 26, 2023 Category: Epidemiology Authors: Vivekanand Jha Saeed M G Al-Ghamdi Guisen Li Mai-Szu Wu Panagiotis Stafylas Lise Retat Joshua Card-Gowers Salvatore Barone Claudia Cabrera Juan Jose Garcia Sanchez Source Type: research

A brazilian nationwide multicenter study on deficiency of deaminase-2 (DADA2)
CONCLUSION: The low number of patients diagnosed with DADA2 in Brazil reinforces the need for disease awareness for this condition. Moreover, the absence of guidelines for diagnosis and management is also necessary (t).PMID:37217999 | DOI:10.1186/s42358-023-00303-5
Source: Adv Data - May 22, 2023 Category: Epidemiology Authors: Adriana Melo Luciana Martins de Carvalho Virginia Paes Leme Ferriani Andr é Cavalcanti Simone Appenzeller Val éria Rossato Oliveira Herberto Chong Neto Nelson Augusto Ros ário Fabiano de Oliveira Poswar Matheus Xavier Guimaraes Cristina Maria Kokron Ra Source Type: research

Characteristics and predictors of hospitalization and death in the first 11  122 cases with a positive RT-PCR test for SARS-CoV-2 in Denmark: a nationwide cohort
ConclusionsIn this nationwide population-based COVID-19 study, increasing age and multimorbidity were strongly associated with hospitalization and death. In the absence of co-morbidities, the mortality was, however,<5% until the age of 80  years.
Source: International Journal of Epidemiology - September 5, 2020 Category: Epidemiology Source Type: research

The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity
Conclusions: Particularly cell dose but also infusion velocity contribute to complications encountered after intra-arterial cell transplantation; this should be considered before planning efficacy studies in stroke rats and, potentially, in patients.
Source: Epidemiologic Perspectives and Innovations - February 9, 2015 Category: Epidemiology Authors: Li-li CuiErja KerkeläAbdulhameed BakreenFranziska NitzscheAnna AndrzejewskaAdam NowakowskiMiroslaw JanowskiPiotr WalczakJohannes BoltzeBarbara LukomskaJukka Jolkkonen Source Type: research

Human neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury
Conclusions: While long-term effects of engrafted hNSCs on the amelioration of ischemic stroke-induced behavioral dysfunction in a rodent model have been reported, our study is the first to show rapid, beneficial impacts on behavioral function (within 24 hours) upon early delivery of hNSCs into the hippocampus.
Source: Epidemiologic Perspectives and Innovations - November 23, 2014 Category: Epidemiology Authors: Lei HuangSunnie WongEvan Y SnyderMilton H HamblinJean-Pyo Lee Source Type: research