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Long-term association of pregnancy and maternal brain structure: the Rotterdam Study
AbstractThe peripartum period is the highest risk interval for the onset or exacerbation of psychiatric illness in women ’s lives. Notably, pregnancy and childbirth have been associated with short-term structural and functional changes in the maternal human brain. Yet the long-term effects of pregnancy on maternal brain structure remain unknown. We investigated a large population-based cohort to examine the asso ciation between parity and brain structure. In total, 2,835 women (mean age 65.2 years; all free from dementia, stroke, and cortical brain infarcts) from the Rotterdam Study underwent magnetic resonance i...
Source: European Journal of Epidemiology - January 6, 2022 Category: Epidemiology Source Type: research

Comparing Vascular Brain Injury and Stroke by Cranial Magnetic Resonance Imaging, Physician-Adjudication, and Self-Report: Data from the Strong Heart Study
Conclusion: In this community-based cohort, self-report for prior stroke had good performance metrics. A majority of participants with VBI did not have overt, clinically recognized events but did have neurological or cognitive symptoms. Data collection methodology for studies in a resource-limited setting must balance practical limitations in costs, accuracy, feasibility, and research goals.Neuroepidemiology
Source: Neuroepidemiology - August 24, 2021 Category: Epidemiology Source Type: research

Prospectively collected lifestyle and health information as risk factors for white matter hyperintensity volume in stroke patients
AbstractMost studies of white matter hyperintensity volume (WMHV) in stroke patients lack reliable information on antecedent exposure to vascular risk factors. By leveraging prospective cohort data, we explored associations between lifestyle and health factors assessed 1  year prior to stroke and WMHV in individuals who experienced an ischemic stroke. This analysis was nested within two large prospective studies of initially healthy individuals. Information on lifestyle factors and health conditions was collected prior to the stroke event through annual or biannual questionnaires. For individuals who experienced their fir...
Source: European Journal of Epidemiology - August 8, 2019 Category: Epidemiology Source Type: research

Lifestyle Risk Factors and Findings on Brain Magnetic Resonance Imaging of Older Adult American Indians: The Strong Heart Study
Conclusions: This study found similar associations between smoking and vascular brain injury among American Indians, as seen in other populations. In particular, these findings support the role of smoking as a key correlate for cerebral atrophy.Neuroepidemiology
Source: Neuroepidemiology - June 4, 2019 Category: Epidemiology Source Type: research

Vascular Risk Factors and Findings on Brain MRI of Elderly Adult American Indians: The Strong Heart Study
Conclusions: This study found risk factors for cerebrovascular disease in American Indians similar to those seen in other populations and provides additional evidence for the important roles of hypertension and diabetes in promoting cerebral infarcts and brain atrophy, respectively.Neuroepidemiology 2019;52:173 –180
Source: Neuroepidemiology - January 27, 2019 Category: Epidemiology Source Type: research

The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocity
Conclusions: Particularly cell dose but also infusion velocity contribute to complications encountered after intra-arterial cell transplantation; this should be considered before planning efficacy studies in stroke rats and, potentially, in patients.
Source: Epidemiologic Perspectives and Innovations - February 9, 2015 Category: Epidemiology Authors: Li-li CuiErja KerkeläAbdulhameed BakreenFranziska NitzscheAnna AndrzejewskaAdam NowakowskiMiroslaw JanowskiPiotr WalczakJohannes BoltzeBarbara LukomskaJukka Jolkkonen Source Type: research

Histological, cellular and behavioral assessments of stroke outcomes after photothrombosis-induced ischemia in adult mice
Conclusion: Our study demonstrated that first a few days is a critical period that causes brain expansion, cellular proliferation and behavioral deficits in photothrombosis-induced ischemic model, and proliferating astrocytes only have a small contribution to the pools of proliferating cells and reactive astrocytes.
Source: Epidemiologic Perspectives and Innovations - May 2, 2014 Category: Epidemiology Authors: Hailong LiNannan ZhangHsinyun LinYang YuQuan-Yu CaiLixin MaShinghua Ding Source Type: research

Treatment outcomes of carotid artery stenting with two types of distal protection filter device
Conclusion: FilterWire EZ and Spider FX are comparable in terms of treatment outcome.
Source: Epidemiologic Perspectives and Innovations - March 8, 2014 Category: Epidemiology Authors: Minoru IkoHiroshi AikawaYoshinori GoKanji NakaiMasanori TsutsumiIwae YuTaichiro MizokamiKimiya SakamotoRitsuro InoueTakafumi MitsutakeAyumu EtoHayatsura HanadaKiyoshi Kazekawa Source Type: research