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Ageing-related markers and risks of cancer and cardiovascular disease: a prospective study in the EPIC-Heidelberg cohort
We examined the associations between five markers of unhealthy ageing; Growth Differentiation Factor-15 (GDF-15), N-terminal pro-brain natriuretic peptide (NT-proBNP), glycated hemoglobin A1c (HbA1C), C-Reactive Protein (CRP) and cystatin-C; with risks of cancer and cardiovascular disease (CVD). We used a case-cohort design embedded in the EPIC-Heidelberg cohort, including a subcohort of 3792 participants along with 4867 incident cases of cancer and CVD. Hazard ratios (HRs) were computed and the strongest associations were used to build weighted multi-marker combinations, and their associations with cancer and CVD risks we...
Source: European Journal of Epidemiology - December 22, 2021 Category: Epidemiology Source Type: research

Human neural stem cells rapidly ameliorate symptomatic inflammation in early-stage ischemic-reperfusion cerebral injury
Conclusions: While long-term effects of engrafted hNSCs on the amelioration of ischemic stroke-induced behavioral dysfunction in a rodent model have been reported, our study is the first to show rapid, beneficial impacts on behavioral function (within 24 hours) upon early delivery of hNSCs into the hippocampus.
Source: Epidemiologic Perspectives and Innovations - November 23, 2014 Category: Epidemiology Authors: Lei HuangSunnie WongEvan Y SnyderMilton H HamblinJean-Pyo Lee Source Type: research

Troponin T, B-type natriuretic peptide, C-reactive protein, and cause-specific mortality
Conclusions: Greater levels of Hs-TnT, NT-proBNP and Hs-CRP are associated with increased risk of death, not just from CVD, but also from some noncardiovascular causes.
Source: Annals of Epidemiology - December 10, 2012 Category: Epidemiology Authors: Oludamilola W. Oluleye, Aaron R. Folsom, Vijay Nambi, Pamela L. Lutsey, Christie M. Ballantyne, ARIC Study Investigators Source Type: research