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Anticoagulation for stroke prevention after embolic stroke of undetermined source of presumably cardiac source: The sail to Ithaca
Eur J Intern Med. 2021 Oct 26:S0953-6205(21)00343-5. doi: 10.1016/j.ejim.2021.09.022. Online ahead of print.NO ABSTRACTPMID:34716078 | DOI:10.1016/j.ejim.2021.09.022
Source: European Journal of Internal Medicine - October 30, 2021 Category: Internal Medicine Authors: Dimitrios Sagris George Ntaios Source Type: research

Colchicine-new horizons for an ancient drug
Eur J Intern Med. 2021 Oct 14:S0953-6205(21)00332-0. doi: 10.1016/j.ejim.2021.10.002. Online ahead of print.ABSTRACTColchicine is an old, inexpensive, and relatively safe anti-inflammatory drug traditionally used in gout and over the last 50 years in familial Mediterranean fever. A search of all high-hierarchy studies (randomized controlled trials [RCTs], systematic reviews and meta-analysis of RCTs) over the last 20 years revealed myriad other evidence-based applications. Colchicine seems efficacious in the treatment of acute pericarditis and prevention of recurrences and the prevention of postcardiac injury syndrome and ...
Source: European Journal of Internal Medicine - October 18, 2021 Category: Internal Medicine Authors: Ami Schattner Source Type: research

Extended venous thromboprophylaxis in patients hospitalized for acute ischemic stroke: A systematic review and meta-analysis
CONCLUSION: In patients hospitalized for acute ischemic stroke, the net clinical benefit may favor extended venous thromboprophylaxis for four to five weeks over standard thromboprophylaxis.PMID:34649783 | DOI:10.1016/j.ejim.2021.09.016
Source: European Journal of Internal Medicine - October 15, 2021 Category: Internal Medicine Authors: Emanuele Valeriani Nicola Potere Matteo Candeloro Silvia Spoto Ettore Porreca Anne Ws Rutjes Marcello Di Nisio Source Type: research

Oral anticoagulants vs antiplatelets in cryptogenic stroke with potential cardiac emboli: Meta-analysis
CONCLUSIONS: OACs compared with antiplatelet therapies were associated with a reduced recurrent ischemic stroke risk and OACs might be a viable non-procedural alternative in patients with cryptogenic stroke and potential cardiac emboli.PMID:34419310 | DOI:10.1016/j.ejim.2021.08.002
Source: European Journal of Internal Medicine - August 22, 2021 Category: Internal Medicine Authors: Wen-Yi Huang Bruce Ovbiagele Meng Lee Source Type: research

Detection of subclinical atrial fibrillation after cryptogenic stroke using implantable cardiac monitors
CONCLUSIONS: In a real-world population, ICM detected SCAF in more than a quarter of CS patients. This experience confirms the relevance of implanting CS patients, for maximizing the possibilities to detect AF, following failure of Holter monitoring, according to guidelines. However, there is need to demonstrate that shift to oral anticoagulation following SCAF detection is associated with reduced risk of recurrent stroke.PMID:34247889 | DOI:10.1016/j.ejim.2021.06.022
Source: European Journal of Internal Medicine - July 12, 2021 Category: Internal Medicine Authors: Andrea Ungar Francesca Pescini Martina Rafanelli Maria Vittoria De Angelis Massimiliano Faustino Caterina Tomaselli Alfredo Petrone Giovanni Forleo Giovanni Morani Stefano Forlivesi Giulio Molon Alessandro Adami Massimiliano Maines Chiara Stegagno Anna Po Source Type: research

Device-detected atrial high rate episodes and the risk of stroke/thrombo-embolism and atrial fibrillation incidence: a systematic review and meta-analysis
CONCLUSIONS: AHRE are significantly associated with systemic thromboembolism and incident clinical AF. Further studies are needed to improve patients' risk stratification and management.PMID:34154879 | DOI:10.1016/j.ejim.2021.05.038
Source: European Journal of Internal Medicine - June 22, 2021 Category: Internal Medicine Authors: Marco Vitolo Jacopo F Imberti Anna Maisano Alessandro Albini Niccol ò Bonini Anna Chiara Valenti Vincenzo L Malavasi Marco Proietti Jeff S Healey Gregory Yh Lip Giuseppe Boriani Source Type: research

Low bleeding and thromboembolic risk with continued dabigatran during cardiovascular interventions: the GLORIA-AF study
CONCLUSIONS: More than two thirds of the interventions were performed with uninterrupted dabigatran therapy, of which most were AF-cardioversions. Uninterrupted dabigatran therapy was associated with low major bleeding and stroke/systemic embolism risk, supporting the favourable safety and effectiveness profile of dabigatran in clinical practice-based settings.PMID:34120814 | DOI:10.1016/j.ejim.2021.05.020
Source: European Journal of Internal Medicine - June 14, 2021 Category: Internal Medicine Authors: Sake J van der Wall Gregory Y H Lip Christine Teutsch Oskars Kalejs Philippe Lyrer Christian Hall Sergio J Dubner Hans-Christoph Diener Jonathan L Halperin Chang Sheng Ma Kenneth J Rothman Kristina Zint Dongmei Zhai Menno V Huisman GLORIA-AF Investigators Source Type: research

Risk of stroke in CYP2C19 LoF polymorphism carrier coronary artery disease patients undergoing clopidogrel therapy: An ethnicity-based updated meta-analysis
CONCLUSION: Our meta-analysis confirmed that the presence of CYP2C19 LoF alleles increases the risk of stroke and composite events recurrence in the worldwide population, especially in Asians undergoing clopidogrel treatment. Alternative antiplatelet therapy should be investigated thoroughly for the intermediate and poor metabolizers.PMID:34092486 | DOI:10.1016/j.ejim.2021.05.022
Source: European Journal of Internal Medicine - June 7, 2021 Category: Internal Medicine Authors: Sarah Jafrin Nura Ershad Naznin Md Sharif Reza Md Abdul Aziz Mohammad Safiqul Islam Source Type: research

Prognostic impact of coronary microvascular dysfunction in patients with myocardial infarction with non-obstructive coronary arteries
CONCLUSIONS: caIMR is a strong predictor of clinical outcome among MINOCA patients. The evaluation of IMR can provide an objective risk stratification method for patients with MINOCA.PMID:34092485 | DOI:10.1016/j.ejim.2021.05.027
Source: European Journal of Internal Medicine - June 7, 2021 Category: Internal Medicine Authors: Fuad A Abdu Lu Liu Abdul-Quddus Mohammed Guoqing Yin Bin Xu Wen Zhang Siling Xu Xian Lv Rui Fan Cailin Feng Tingting Shi Yunlong Huo Yawei Xu Wenliang Che Source Type: research

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