Filtered By:
Specialty: Pediatrics
Source: Pediatric Research

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 48 results found since Jan 2013.

Precise neonatal arterial ischemic stroke classification with a three-dimensional map of the arterial territories of the neonatal brain.
CONCLUSION: The ATNB map has been proven useful to precisely identify the arterial territories affected by an NAIS, as well as to increase the accuracy of clinical diagnoses. PMID: 31835270 [PubMed - as supplied by publisher]
Source: Pediatric Research - December 12, 2019 Category: Pediatrics Authors: Núñez C, Arca G, Agut T, Stephan-Otto C, García-Alix A Tags: Pediatr Res Source Type: research

The emerging role of immunothrombosis in paediatric conditions.
Abstract Immunothrombosis is a physiological process based on the release of neutrophil extracellular traps (NETs) to immobilise, contain and kill bacteria. This is an innate immune response in which the local activation of blood coagulation exerts the critical protective function during microbial infection. In recent years, there has been much interest in the adult literature about the key role of immunothrombosis in pathologic states including thrombosis, cancer, sepsis and trauma. Currently, little research has been done into its role in paediatric conditions. We aim to summarise the most relevant evidences reg...
Source: Pediatric Research - February 26, 2019 Category: Pediatrics Authors: Franchi T, Eaton S, De Coppi P, Giuliani S Tags: Pediatr Res Source Type: research

Diffuse optical tomography for the detection of perinatal stroke at the cot side: a pilot study.
CONCLUSION: This suggests that DOT and correlation-based analyses in the low-frequency range can potentially aid the early detection of perinatal stroke, prior to MRI acquisition. Additional methodological advances are required to increase the sensitivity and specificity of this technique. PMID: 30759451 [PubMed - as supplied by publisher]
Source: Pediatric Research - February 13, 2019 Category: Pediatrics Authors: Chalia M, Dempsey LA, Cooper RJ, Lee CW, Gibson AP, Hebden JC, Austin T Tags: Pediatr Res Source Type: research

The effect of unilateral stroke on autonomic function in the term newborn.
CONCLUSION: Based on these findings, it is difficult to reconcile the functional topography of the central autonomic system in term newborns with that currently proposed for the normal mature brain. Further investigation is clearly needed. PMID: 30712058 [PubMed - as supplied by publisher]
Source: Pediatric Research - February 2, 2019 Category: Pediatrics Authors: Reich DA, Govindan RB, Whitehead MT, Wang J, Chang T, Kota S, du Plessis AJ Tags: Pediatr Res Source Type: research

Soluble receptor for advanced glycation end products as a vasculopathy biomarker in sickle cell disease.
CONCLUSION: Our findings suggest that sRAGE may be considered as a marker for vascular dysfunction in SCD patients. PMID: 30367158 [PubMed - as supplied by publisher]
Source: Pediatric Research - October 26, 2018 Category: Pediatrics Authors: Safwat NA, Kenny MA Tags: Pediatr Res Source Type: research

Brain abnormalities in children and adolescents with chronic kidney disease.
CONCLUSION: Cerebral white matter abnormalities, including white matter injury, are under-recognized in pediatric CKD patients. Brain imaging studies through progression of CKD are needed to determine the timing of white matter injury and any potentially modifiable risk factors. PMID: 29967532 [PubMed - as supplied by publisher]
Source: Pediatric Research - July 2, 2018 Category: Pediatrics Authors: Matsuda-Abedini M, Fitzpatrick K, Harrell WR, Gipson DS, Hooper SR, Belger A, Poskitt K, Miller SP, Bjornson BH Tags: Pediatr Res Source Type: research

Survey of plasma proteins in children with progeria pre-therapy and on-therapy with lonafarnib.
CONCLUSION: This is the first study to employ a multi-analyte array platform in HGPS. Novel potential biomarkers identified in this study should be further validated by correlations with clinical disease status, especially proteins associated with cardiovascular disease and those that normalized with lonafarnib therapy.Pediatric Research accepted article preview online, 17 January 2018. doi:10.1038/pr.2018.9. PMID: 29342131 [PubMed - as supplied by publisher]
Source: Pediatric Research - January 17, 2018 Category: Pediatrics Authors: Gordon LB, Campbell SE, Massaro JM, D'Agostino RB, Kleinman ME, Kieran MW, Moses MA Tags: Pediatr Res Source Type: research

Pediatric brain repair from endogenous neural stem cells of the subventricular zone.
Abstract There is great interest in the regenerative potential of the neural stem cells and progenitors that populate the germinal zones of the immature brain. Studies using animal models of pediatric brain injuries have provided a clearer understanding of the responses of these progenitors to injury. In this review we have compared and contrasted the responses of the endogenous neural stem cells and progenitors of the subventricular zone in animal models of neonatal cerebral hypoxia-ischemia, neonatal stroke, congenital cardiac disease and pediatric traumatic brain injury. We have reviewed the dynamic shifts that...
Source: Pediatric Research - October 13, 2017 Category: Pediatrics Authors: Niimi Y, Levison SW Tags: Pediatr Res Source Type: research

Cellular therapy for traumatic neurological injury.
Abstract Neurological injury is the primary lethal mechanism of injury in children, and the primary etiology of long-term disability after trauma. Laboratories and clinical/translational teams have sought to develop stem/progenitor cell therapies to improve recovery in a clinical setting in which there is no significant reparative option. While none of these treatments are currently standard therapeutics, Phase 2b clinical trials are underway in both adults and children in severe traumatic brain injury and Phase 1/2a trials in spinal cord injury. This review will characterize the cell therapy strategies: cell repl...
Source: Pediatric Research - October 6, 2017 Category: Pediatrics Authors: Cox CS Tags: Pediatr Res Source Type: research

Vitamin D Insufficiency in Neonatal Hypoxic-Ischemic Encephalopathy.
CONCLUSIONS: Serum 25(OH) vitamin D insufficiency is present in the majority of term HIE neonates and is related to lower circulating anti-inflammatory IL-17E. Hypothermia does not mitigate vitamin D deficiency in HIE.Pediatric Research (2017); doi:10.1038/pr.2017.13. PMID: 28099429 [PubMed - as supplied by publisher]
Source: Pediatric Research - January 17, 2017 Category: Pediatrics Authors: Lowe DW, Hollis BW, Wagner CL, Bass T, Kaufman DA, Horgan MJ, Givelichian LM, Sankaran K, Yager JY, Katikaneni LD, Wiest D, Jenkins D Tags: Pediatr Res Source Type: research

Fifty years of brain imaging in neonatal encephalopathy following perinatal asphyxia.
Abstract In the past brain imaging of term infants with hypoxic-ischemic encephalopathy (HIE) was performed with cranial ultrasound (cUS) and computed tomography (CT). Both techniques have several disadvantages sensitivity and specificity is limited compared with magnetic resonance imaging (MRI) and CT makes use of radiation. At present MRI including diffusion weighted MRI during the first week of life, has become the method of choice for imaging infants with HIE. In addition to imaging, blood vessels and blood flow can be visualized using MR angiography, MR venography, and arterial spin labeling. Since the use of...
Source: Pediatric Research - November 1, 2016 Category: Pediatrics Authors: Groenendaal F, de Vries LS Tags: Pediatr Res Source Type: research

Pediatric Sickle Cell Disease - Past Successes and Future Challenges.
Abstract Once a fatal disease of childhood, more than 95% of patients born today with sickle cell disease (SCD) in developed countries are expected to survive into adulthood, largely because of improvements in supportive and preventive care (newborn screening, penicillin prophylaxis, transcranial Doppler (TCD) screening). Hydroxyurea (HU) therapy, the only oral medication currently available to prevent SCD complications, has become more widespread over the past 20 years. The NHLBI recommends that HU be offered to all patients with HbSS beginning at nine months of age, and the recently published Abnormal TCD with T...
Source: Pediatric Research - October 4, 2016 Category: Pediatrics Authors: Meier ER, Rampersad A Tags: Pediatr Res Source Type: research

Age-specific onset and distribution of the natural anticoagulant deficiency in pediatric thromboembolism.
CONCLUSION: Stroke in low PC-infants, and deep vein thrombosis in low PS-/AT-schoolers could be targeted for genetic screening of pediatric thrombophilias.Pediatric Research (2015); doi:10.1038/pr.2015.180. PMID: 26372516 [PubMed - as supplied by publisher]
Source: Pediatric Research - September 15, 2015 Category: Pediatrics Authors: Ichiyama M, Ohga S, Ochiai M, Tanaka K, Matsunaga Y, Kusuda T, Inoue H, Ishimura M, Takimoto T, Koga Y, Hotta T, Kang D, Hara T Tags: Pediatr Res Source Type: research

Repeated Autologous Umbilical Cord Blood Infusions are Feasible and had No Acute Safety Issues in Young Babies with Congenital Hydrocephalus.
CONCLUSION: Cryopreserved CB products may be effectively manipulated to provide multiple CB doses. Repeated intravenous infusion of autologous CB is safe and feasible in young babies with congenital hydrocephalus.Pediatric Research (2015); doi:10.1038/pr.2015.161. PMID: 26331765 [PubMed - as supplied by publisher]
Source: Pediatric Research - September 2, 2015 Category: Pediatrics Authors: Sun JM, Grant GA, McLaughlin C, Allison J, Fitzgerald A, Waters-Pick B, Kurtzberg J Tags: Pediatr Res Source Type: research

Non-invasive measurements of hemodynamic transition directly after birth.
Conclusion: LVD and LVO significantly increased the first 5 minutes after birth and stabilized at 10 minutes, whereas BP remained stable. LVO and LVD increase are presumably due to increasing left ventricular preload resulting from pulmonary blood flow and ductal shunting increase.Pediatric Research (2013); doi:10.1038/pr.2013.241. PMID: 24346112 [PubMed - as supplied by publisher]
Source: Pediatric Research - December 17, 2013 Category: Pediatrics Authors: van Vonderen JJ, Roest AA, Siew ML, Blomf NA, van Lith JM, Walther FJ, Hooper SB, Te Pas AB Tags: Pediatr Res Source Type: research