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What Are the Complications of Sickle Cell Trait?
Discussion Sickle cell disease (SCD) is a group of inherited blood disorders where there are abnormal hemoglobin molecules and the red blood cells take on a characteristic sickled shape instead of a rounded shape. Sickled hemoglobin provides an evolutionary advantage of giving the individual increased protection against severe and cerebral malaria. The sickled shape doesn’t move through the vascular system as well and therefore is more likely to aggregate in small vessels causing an increased risk of vaso-occlusive disease, acute chest syndrome, splenic sequestration, and priapism. There is also an increased risk of ...
Source: PediatricEducation.org - September 4, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Utility of Inferior Vena Cava Distensibility and Respiratory Variation in Peak Aortic Blood Flow Velocity to Predict Fluid Responsiveness in Children with Shock
ConclusionsIn this study, authors found that ∆IVC and ΔVpeak were good predictors of fluid responsiveness in ventilated children with shock.
Source: Indian Journal of Pediatrics - June 6, 2023 Category: Pediatrics Source Type: research

MTHFR C677T Polymorphism, Plasma Homocysteine, and PDGF-AA Levels and Transcranial Doppler Velocity in Children with Sickle Cell Disease
CONCLUSION: PDGF-AA and tHcy levels could be used as predictive markers for stroke in SCD children. MTHFR Polymorphism contributes to elevated tHcy levels.PMID:37260067
Source: Indian Pediatrics - June 1, 2023 Category: Pediatrics Authors: Asmaa A Mahmoud Nahla M S Abd El Hady Mohammed S Rizk Ahmed M El-Hawwary Nagwan Y Saleh Source Type: research

Highlights from this issue
The view from here... On the edge of Islamabad, close to the start of the Karakoram highway and the Punjab- Khyber-Pakhtunkhwa border lies a semicircular range of mountains, the Margalla Hills. Densely forested and often engulfed in low cloud, which add to their mystique, they lend a sense of calm to the city. The climb is something of a vertiginous scramble, but the reward for reaching the summit far outweighs the sweat generated during the ascent. On a good day, one can see for what feels like forever – Peshawar and the Afghan border to the West, India to the East... We all have complicated clinical lives: and owe ...
Source: Archives of Disease in Childhood - June 17, 2022 Category: Pediatrics Authors: Brown, N. Tags: Atoms Source Type: research

Stroke with Myocarditis: A Different Post-COVID Syndrome
Source: Indian Journal of Pediatrics - March 17, 2022 Category: Pediatrics Source Type: research

Profile of Neurological Manifestations in Children Presenting With Rickettsial Disease
CONCLUSION: Early recognition of rickettsial infection as a cause of neurological manifestation would facilitate early specific management palsy.PMID:35014614
Source: Indian Pediatrics - January 11, 2022 Category: Pediatrics Authors: S B Chiranth K R Ashwini Vykuntraju K Gowda K S Sanjay Maaz Ahmed G V Basavaraja Source Type: research

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