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Ischemia-Reperfusion Injury in Sickle Cell Disease: From Basics to Therapeutics.
Abstract Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies worldwide, affecting almost 400,000 newborns globally each year. It is characterized by chronic hemolytic anemia and endothelial dysfunction, resulting in a constant state of disruption of the vascular system and leading to recurrent episodes of ischemia-reperfusion injury (I/RI) to multiple organ systems. I/RI is a fundamental vascular pathobiological paradigm and contributes to morbidity and mortality in a wide range of conditions, including myocardial infarction, stroke, acute kidney injury, and transplantation. I/RI is c...
Source: The American Journal of Pathology - March 26, 2019 Category: Pathology Authors: Ansari J, Gavins FNE Tags: Am J Pathol Source Type: research

Reperfusion therapy —what’s with the obstructed, leaky and broken capillaries?
Publication date: Available online 21 September 2017 Source:Pathophysiology Author(s): D. Neil Granger, Peter R. Kvietys Microvascular dysfunction is well established as an early and rate-determining factor in the injury response of tissues to ischemia and reperfusion (I/R). Severe endothelial cell dysfunction, which can develop without obvious morphological cell injury, is a major underlying cause of the microvascular abnormalities that accompany I/R. While I/R-induced microvascular dysfunction is manifested in different ways, two responses that have received much attention in both the experimental and clinical setting a...
Source: Pathophysiology - September 22, 2017 Category: Pathology Source Type: research

Preeclampsia and health risks later in life: an immunological link
Abstract Pregnancy represents a period of physiological stress, and although this stress is experienced for a very modest portion of life, it is now recognized as a window to women’s future health, often by unmasking predispositions to conditions that only become symptomatic later in life. In normal pregnancy, the mother experiences mild metabolic syndrome-like condition through week 20 of gestation. A pronounced phenotype of metabolic syndrome may program pregnancy complications such as preeclampsia. Preeclampsia is a serious complication with a myriad of manifestations for mother and offspring. This pregnancy ...
Source: Seminars in Immunopathology - June 22, 2016 Category: Pathology Source Type: research