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Specialty: Allergy & Immunology
Condition: Stroke
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Total 746 results found since Jan 2013.
HDAC1 is Involved in Neuroinflammation and Blood-Brain Barrier Damage in Stroke Pathogenesis
Source: Journal of Inflammation Research - September 18, 2023 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock
ConclusionThese results demonstrate the potential utility of a mechanically ventilated rabbit model that reproduced hallmark clinical features of hyperdynamic septic shock and the translational potential of immunotherapy targeting S. aureus virulence factors for the prevention of staphylococcal septic shock.
Source: Frontiers in Immunology - September 15, 2023 Category: Allergy & Immunology Source Type: research
The impact of EMA recommendations on the real-life use of Janus kinases inhibitors for rheumatoid arthritis: the Expanded Risk Score in RA as a tool to quantify the risk of cardiovascular events
ConclusionsRigorous application of EMA indications in clinical practice could result in the exclusion of a large proportion of RA patients from treatment with JAKis. A proper quantification of the risk for MACE by dedicated tools as ERS-RA is advocated to better tailor the management of RA.
Source: Frontiers in Immunology - August 31, 2023 Category: Allergy & Immunology Source Type: research
TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2
Source: Journal of Inflammation Research - August 28, 2023 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke
Source: Journal of Inflammation Research - August 23, 2023 Category: Allergy & Immunology Tags: Journal of Inflammation Research Source Type: research
Interleukin-33 improves the neurogenesis of neural stem cells in perinatal brain after hypoxia-ischemia
Int Immunopharmacol. 2023 Aug 11;123:110778. doi: 10.1016/j.intimp.2023.110778. Online ahead of print.ABSTRACTPerinatal hypoxia-ischemia (HI) insult is an important cause of neonatal encephalopathy, and the effective therapeutic approaches are currently limited. Interleukin (IL)-33 acts as a member of the IL-1 superfamily and has been shown to be neuroprotective following experimental neonatal HI and adult stroke. Here, we explore the effect of IL-33 and its specific receptor ST2 axis on endogenous neurogenesis in neonatal brain after HI. ST2 was found on the surface of NSCs, and the expression of ST2 was further enhanced ...
Source: International Immunopharmacology - August 13, 2023 Category: Allergy & Immunology Authors: Jing Tian Jieqiong Zhu Qiuxiang Fan Xiaotian Luo Qianying Nie Jingwei Yu Xiaoyong Wu Yanli Tang Tao Liu Hui Yin Source Type: research
Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases
MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific RNAs and regulate many cellular processes. Neuroinflammation plays the pivotal role in the occurrence and development of multiple central nervous system (CNS) diseases. The ability of miRNAs to enhance or restrict neuroinflammatory signaling pathways in CNS diseases is an emerging and important research area, including neurodegenerative diseases, stroke, and traumatic brain injury (TBI). In this review, we summarize the roles and regulatory mechanisms of recently identified miRNAs involved in neuroinflammation-mediated CNS dis...
Source: Frontiers in Immunology - August 11, 2023 Category: Allergy & Immunology Source Type: research
Tregs depletion aggravates activation of astrocytes by modulating IL-10/GXP4 following cerebral infarction
ConclusionTregs depletion attenuates renal fibrosis by modulating IL-10/GPX4 following cerebral infarction.
Source: Frontiers in Immunology - August 9, 2023 Category: Allergy & Immunology Source Type: research
Revisiting the role of the complement system in intracerebral hemorrhage and therapeutic prospects
Int Immunopharmacol. 2023 Aug 6;123:110744. doi: 10.1016/j.intimp.2023.110744. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. Despite its lower incidence than ischemic stroke, ICH remains a significant contributor to stroke-related mortality, and most survivors experience poor outcomes that significantly impact their quality of life. ICH has been accompanied by various complex pathological damage, including mechanical damage of brain tissue, hematoma mass effect, and th...
Source: International Immunopharmacology - August 8, 2023 Category: Allergy & Immunology Authors: Yuanyuan Li Chenxi Tao Na An Haoqi Liu Zhenhong Liu Hongrui Zhang Yikun Sun Yanwei Xing Yonghong Gao Source Type: research
A Narrative Review of the Neurological Manifestations of Human Adenosine Deaminase 2 Deficiency
AbstractDeficiency of human adenosine deaminase type 2 (DADA2) is a complex systemic autoinflammatory disorder characterized by vasculopathy, immune dysregulation, and hematologic abnormalities. The most notable neurological manifestations of DADA2 are strokes that can manifest with various neurological symptoms and are potentially fatal. However, neurological presentations can be diverse. We here present a review of the neurological manifestations of DADA2 to increase clinical awareness of DADA2 as the underlying diagnosis. We reviewed all published cases of DADA2 from 1 January 2014 until 19 July 2022 found via PubMed. A...
Source: Journal of Clinical Immunology - August 7, 2023 Category: Allergy & Immunology Source Type: research
Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018
ConclusionIn asthmatics, higher levels of SII and SIRI significantly increased the prevalence of stroke, with its association being more pronounced in individuals with coexisting obesity and hyperlipidaemia. SII and SIRI are relatively stable novel inflammatory markers in the asthmatic population, with SIRI having a better predictive value for stroke prevalence than SII.
Source: Frontiers in Immunology - August 4, 2023 Category: Allergy & Immunology Source Type: research
The role of macrophage ion channels in the progression of atherosclerosis
Atherosclerosis is a complex inflammatory disease that affects the arteries and can lead to severe complications such as heart attack and stroke. Macrophages, a type of immune cell, play a crucial role in atherosclerosis initiation and progression. Emerging studies revealed that ion channels regulate macrophage activation, polarization, phagocytosis, and cytokine secretion. Moreover, macrophage ion channel dysfunction is implicated in macrophage-derived foam cell formation and atherogenesis. In this context, exploring the regulatory role of ion channels in macrophage function and their impacts on the progression of atheros...
Source: Frontiers in Immunology - July 31, 2023 Category: Allergy & Immunology Source Type: research
Microbiota, diet and the gut-brain axis in multiple sclerosis and acute stroke
This article is protected by copyright. All rights reserved.PMID:37470461 | DOI:10.1002/eji.202250229
Source: European Journal of Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Laura Diaz-Marugan Johan B Kantsj รถ Andrina Rutsch Francesca Ronchi Source Type: research
