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Pharmacogenomics in Stroke and Cardiovascular Disease Pharmacogenomics in Stroke and Cardiovascular Disease
This review provides an overview of the genetic variants that influence individual responses to aspirin, clopidogrel, warfarin, and statins and the clinical implications for stroke patients.Stroke
Source: Medscape Today Headlines - January 26, 2023 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

Drug May Be Safer Option Against Repeat Stroke
The risk of another stroke caused by a blood clot was halved for patients who took the drug Pletal plus aspirin or clopidogrel, versus those who took aspirin or clopidogrel alone.
Source: WebMD Health - February 7, 2019 Category: Consumer Health News Source Type: news

Dual Antiplatelet Therapy With Cilostazol Cuts Recurrent Stroke Dual Antiplatelet Therapy With Cilostazol Cuts Recurrent Stroke
New results show cilostazol plus aspirin or clopidogrel reduced recurrent stroke rate by half over aspirin or clopidogrel alone in high-risk stroke patients without increased bleeding.Medscape Medical News
Source: Medscape Medical News Headlines - February 7, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

POINT: Success at Last for Dual Antiplatelet After Stroke, TIA POINT: Success at Last for Dual Antiplatelet After Stroke, TIA
A combination of clopidogrel plus aspirin reduced major ischemic events vs aspirin alone in patients with minor ischemic stroke or high-risk TIA in this long-awaited trial.Medscape Medical News
Source: Medscape Today Headlines - May 17, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Ticagrelor for Stroke: Encouraging Results in Platelet Study Ticagrelor for Stroke: Encouraging Results in Platelet Study
Ticagrelor was associated with a lower rate of high on-treatment platelet reactivity than clopidogrel in Asian patients who had had a minor stroke or high-risk TIA in the PRINCE trial.Medscape Medical News
Source: Medscape Medical News Headlines - February 23, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Blood-thinning drugs may reduce dementia risk in people with irregular heartbeats
Conclusion If you’ve been diagnosed with AF and you have been prescribed anticoagulant treatments such as warfarin or clopidogrel, we already know they protect you against having a stroke. This study suggests they may also help to protect you against dementia. Cutting the risk of dementia for people who have a raised risk because of AF would be an exciting step forward. Unfortunately, we can’t tell from this study whether the protection against dementia was down to the anticoagulants, because of the possible effect of unmeasured confounding factors. Usually, we would want to see a randomised controlled trial (RCT) to f...
Source: NHS News Feed - October 25, 2017 Category: Consumer Health News Tags: Neurology Source Type: news

Prasugrel Fails to Show Noninferiority to Clopidogrel in Stroke Prasugrel Fails to Show Noninferiority to Clopidogrel in Stroke
Despite being a more potent antiplatelet agent, prasugrel failed to show noninferiority to clopidogrel in reducing vascular events in stroke patients in a new phase 3 trial.Medscape Medical News
Source: Medscape Medical News Headlines - June 1, 2017 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Why 5,000 People Are Suing Over Plavix
Legal action is apparently moving forward involving lawsuits filed by thousands of people who say they suffered serious injuries by taking the once-heralded blood-thinning drug Plavix. The California Supreme Court ruled late last month that eight product liability lawsuits against Plavix manufacturer Bristol-Myers Squibb and Plavix distributor McKesson Corporation can proceed in San Francisco Superior Court. Those eight cases involved 678 plaintiffs. They may soon be joined by a multitude of other cases, involving about 5,000 plaintiffs, that have been filed around the country. There is no word yet on whether Bristol-My...
Source: Healthy Living - The Huffington Post - September 13, 2016 Category: Consumer Health News Source Type: news

Real-world data confirm benefits of ticagrelor in ACS
A prospective study of more than 45,000 patients with acute coronary syndromes has shown that the risk of death or readmission with myocardial infarction or stroke is 15% lower with ticagrelor than with clopidogrel.
Source: MedWire News - July 26, 2016 Category: Consumer Health News Tags: Acute coronary syndromes Source Type: news

CYP2C19 gene variants undermine clopidogrel stroke prevention
The first look at CYP2C19 mutations in the context of a randomised controlled trial has confirmed suspicions that they affect the efficacy of clopidogrel in patients with acute stroke.
Source: MedWire News - June 24, 2016 Category: Consumer Health News Tags: Stroke Source Type: news

ASK THE DOCTOR: Do I really need to keep taking my stroke tablets? 
Graham had a transient ischaemic attack ten months ago and wonders whether he still needs to take clopidogrel. Dr Scurr advises.
Source: the Mail online | Health - April 13, 2015 Category: Consumer Health News Source Type: news

Millions of adults skip medications due to their high cost
Medications can do wonderful things, from fighting infection to preventing stroke and warding off depression. But medications don’t work if they aren’t taken. Some people don’t take their medications as prescribed because they forget, or are bothered by side effects. A new report from the National Center for Health Statistics shines the light on another reason: some people can’t pay for their medications. The survey, by NCHS researchers Robin A. Cohen and Maria A. Villarroel, found that about 8% of adult Americans don’t take their medicines as prescribed because they can’t afford them. I...
Source: New Harvard Health Information - January 30, 2015 Category: Consumer Health News Authors: Howard LeWine, M.D. Tags: Drugs and Supplements medication costs Source Type: news

Clopidogrel Plus Aspirin Promising in Stroke PreventionClopidogrel Plus Aspirin Promising in Stroke Prevention
For preventing stroke after TIA, are 2 drugs better than 1? Medscape Neurology
Source: Medscape Today Headlines - October 30, 2013 Category: Consumer Health News Tags: Neurology & Neurosurgery Commentary Source Type: news

Clopidogrel Contribution to Fracture Risk in Stroke 'Minor'Clopidogrel Contribution to Fracture Risk in Stroke 'Minor'
The increased fracture risk associated with the stroke itself far exceeds that associated with clopidogrel, new research indicates. Medscape Medical News
Source: Medscape Today Headlines - October 11, 2013 Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news

Risk Of Stroke Effectively Reduced By Simple 2-Drug Combination
Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs - clopidogrel and aspirin- lowered the risk of stroke by almost one-third, compared to the standard therapy of aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks. Described this week in the New England Journal of Medicine (July 4, 2013 print issue), the clinical trial was conducted at multiple sites in China and designed in partnership with a physician at UC San Francisco...
Source: Health News from Medical News Today - June 28, 2013 Category: Consumer Health News Tags: Stroke Source Type: news

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