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Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Asymptomatic Carotid Stenosis Is Associated With Circadian and Other Variability in Embolus Detection
Conclusions: Embolism associated with asymptomatic carotid stenosis shows circadian variation with highest rates 4–6 h before midday. This corresponds with peak circadian incidence of stroke and other vascular complications. These and ASED Study results show that monitoring frequency, duration, and time of day are important in ES detection. Introduction Transcranial Doppler (TCD) detected microembolism in the ipsilateral middle cerebral artery (MCA) may help stratify the risk of stroke and other arterial disease complications in persons with advanced (≥60%) asymptomatic carotid stenosis. If so, this t...
Source: Frontiers in Neurology - April 15, 2019 Category: Neurology Source Type: research

Platelet Count Predicts Adverse Clinical Outcomes After Ischemic Stroke or TIA: Subgroup Analysis of CNSR II
Conclusion: In ischemic stroke or TIA patients with platelet count within normal range, platelet count may be a qualified predictor for long-term recurrent stroke, mortality, and poor functional outcome. Introduction Platelets exert a critical role in the pathogenesis of atherosclerotic complications of cardio-cerebrovascular disease, contributing to thrombus formation, and embolism (1, 2). Previous literature reported that platelets of various size and density are produced by megakaryocytes of different size and stages of maturation in different clinical conditions, suggesting various platelet patterns in differen...
Source: Frontiers in Neurology - April 11, 2019 Category: Neurology Source Type: research

A systematic review of the incidence and prevalence of cardiac, cerebrovascular, and peripheral vascular disease in multiple sclerosis
Conclusion: Despite the relatively high prevalence of some vascular comorbidities in the MS population, important gaps exist in our understanding of their epidemiology. Most of our knowledge is based on studies conducted in a small number of regions.
Source: Multiple Sclerosis - March 2, 2015 Category: Neurology Authors: Marrie, R. A., Reider, N., Cohen, J., Stuve, O., Trojano, M., Cutter, G., Reingold, S., Sorensen, P. S. Tags: Systematic Review Source Type: research

Hypertensive Disorders in Pregnancy and Future Risk of Stroke: A Systematic Review (P2.114)
CONCLUSIONS: Hypertension in pregnancy likely carries an increased risk for stroke in later life, especially when associated with pre-eclampsia/eclampsia. There may be benefit in targeting these women for close risk-factor monitoring and control beyond the post-partum period.Disclosure: Dr. Ganesh has nothing to disclose. Dr. Sarna has nothing to disclose. Dr. Mehta has nothing to disclose. Dr. Smith has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Ganesh, A., Sarna, N., Mehta, R., Smith, E. Tags: Cerebrovascular Disease and Interventional Neurology: Childhood and Young Adult Source Type: research

Can Patient or Arterial Characteristics Guide the Choice between Carotid Angioplasty and Carotid Endarterectomy? The Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) (P01.225)
CONCLUSIONS: Beyond the previously described differential treatment efficacy by age, there were no other patient or arterial characteristic detected to identify patient subgroups that would differentially benefit from the choice of CAS versus CEA. Our inability to identify factors to guide treatment choices could be due to the low number of stroke and death events, incomplete information regarding arterial characteristics in the CEA population, or the potential exclusion of "high risk" groups (such as those with severe arterial tortuosity) from the study.Disclosure: Dr. Moore has nothing to disclose. Dr. Roubin has receive...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Moore, W., Roubin, G., Rosenfield, K., Altafullah, I., Ansel, G., Voeks, J., Meschia, J., Lal, B., Howard, G., Brott, T. Tags: P01 Cerebrovascular Disease I Source Type: research

Relation of Intracranial Stenosis and Elevated Carotid Intimal Medial Thickness in Black Caribbean Ischemic Stroke Patients (P03.187)
CONCLUSIONS: Our preliminary results suggest that increased MCA velocity is independent elevated CIMT, a biomarker for atherosclerosis, in anterior circulation ischemic stroke in CBs. History of hypercholesterolemia appears to be an important risk factor in atherosclerosis in CBs. This data suggests further prospective studies of MCA stenosis mechanisms in CBs are warranted.Disclosure: Dr. Law has nothing to disclose. Dr. Hao has nothing to disclose. Dr. Rojas-Soto has nothing to disclose. Dr. Yu has nothing to disclose. Dr. Baird has received personal compensation for activities as a speaker at the International Conferenc...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Law, S., Hao, Q., Rojas-Soto, D., Yu, H., Baird, A. Tags: P03 Cerebrovascular Disease III Source Type: research