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Design and evaluation of a biosynthesized cellulose drug releasing duraplasty
In this study, a novel biosynthesized cellulose (BC)-based drug releasing duraplasty was developed and studied. The BC duraplasty fabrication process allowed readily incorporation of growth factors (GFs) in a sterile manner and control of physical and mechanical properties of the resulting duraplasty. Our results showed that BC duraplasty containing the highest amount of dry cellulose presented swelling ratio of 496 ± 27%, Young's modulus of 0.37 ± 0.02 MPa, ultimate tensile strength of 0.96 ± 0.02 MPa, while releasing GFs for over 10 days. In addition, neural stem/progenitor cell (NSPC) cultures demonstrated t...
Source: Materials Science and Engineering: C - January 28, 2020 Category: Materials Science Source Type: research

Surface evaluation of titanium oxynitride coatings used for developing layered cardiovascular stents
Publication date: June 2019Source: Materials Science and Engineering: C, Volume 99Author(s): Nataliia Beshchasna, Au Yeung Kwan Ho, Muhammad Saqib, Honorata Kraśkiewicz, Łukasz Wasyluk, Oleg Kuzmin, Oana Cristina Duta, Denisa Ficai, Roxana Doina Trusca, Anton Ficai, Vladimir F. Pichugin, Jörg Opitz, Ecaterina AndronescuAbstractStents are important medical devices used to increase the quality and life expectancy of patients with heart diseases and stroke, leading causes of death, worldwide. In order to minimize the risk of restenosis, different coating on bare metal stents (BMS) such as polymer coatings; titanium dioxide...
Source: Materials Science and Engineering: C - February 2, 2019 Category: Materials Science Source Type: research

Design of lactoferrin modified lipid nano-carriers for efficient brain-targeted delivery of nimodipine
Publication date: 1 November 2018Source: Materials Science and Engineering: C, Volume 92Author(s): Chaoyue Zhao, Jiulong Zhang, Haiyang Hu, Mingxi Qiao, Dawei Chen, Xiuli Zhao, Chunrong YangAbstractBlood-brain barrier (BBB) was the major obstacle for efficient delivery of therapeutic agents to brain tissue. To overcome this barrier, a novel lactoferrin modified long circulation nanostructured lipid carriers (Lf-NLC) was designed and synthesized for the efficient delivery of neuroprotective agent nimodipine (NMD) to brain tissue. NMD loaded Lf-NLC was optimized to exhibit a small and uniform particle size distribution and h...
Source: Materials Science and Engineering: C - September 1, 2018 Category: Materials Science Source Type: research

Fibrinolytic PLGA nanoparticles for slow clot lysis within abdominal aortic aneurysms attenuate proteolytic loss of vascular elastic matrix
Publication date: 1 February 2016 Source:Materials Science and Engineering: C, Volume 59 Author(s): Balakrishnan Sivaraman, Andrew Sylvester, Anand Ramamurthi Abdominal aortic aneurysms (AAAs) involve chronic overexpression of proteases in the aortic wall that result in disruption of elastic fibers and consequent loss of vessel elasticity. Nearly 75% of AAAs contain flow-obstructing, fibrin-rich intraluminal thrombi (ILT), which act as a) a bioinert shield, protecting the underlying AAA wall from high hemodynamic stresses, and b) a reservoir of inflammatory cells and proteases that cause matrix breakdown. For these re...
Source: Materials Science and Engineering: C - October 24, 2015 Category: Materials Science Source Type: research