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Improving outcomes in intracerebral hemorrhage through microglia/macrophage-targeted IL-10 delivery with phosphatidylserine liposomes
Biomaterials. 2023 Aug 15;301:122277. doi: 10.1016/j.biomaterials.2023.122277. Online ahead of print.ABSTRACTIntracerebral hemorrhage (ICH) remains the most lethal type of stroke, and effective clinical therapies that can speed up hematoma resolution after ICH are still lacking. While the beneficial effects of IL-10 on ICH recovery have been demonstrated, the clinical translation of IL-10 requires effective delivery methods by which sufficient IL-10 can be delivered to ICH-affected regions in the brain. Here we report the use of a phosphatidylserine (PS) liposome (PSL)-based nanoparticle system for microglia/macrophage-tar...
Source: Biomaterials - August 19, 2023 Category: Materials Science Authors: Ranran Han Xi Lan Zheng Han Honglei Ren Safiya Aafreen Wenshen Wang Zhipeng Hou Tianyue Zhu Andrew Qian Xiaoning Han Raymond C Koehler Guanshu Liu Source Type: research

A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
Biomaterials. 2022 Aug 15:121729. doi: 10.1016/j.biomaterials.2022.121729. Online ahead of print.ABSTRACTBrain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one of the leading causes of hemorrhagic stroke in children and young adults. Most human sporadic brain AVMs are associated with genetic activating mutations in the KRAS gene. Our goal was to develop an in vitro model that would allow for simultaneous morphological and functional phenotypic data capture in real time during AVM disease progress...
Source: Biomaterials - August 23, 2022 Category: Materials Science Authors: Kayla Soon Mengyuan Li Ruilin Wu Angela Zhou Negar Khosraviani Williamson D Turner Joshua D Wythe Jason E Fish Sara S Nunes Source Type: research

Fucoidan-functionalized polysaccharide submicroparticles loaded with alteplase for efficient targeted thrombolytic therapy
Biomaterials. 2021 Aug 30;277:121102. doi: 10.1016/j.biomaterials.2021.121102. Online ahead of print.ABSTRACTIntravenous administration of fibrinolytic drugs is the standard treatment of acute thrombotic diseases. However, current fibrinolytics exhibit limited clinical efficacy because of their short plasma half-lives and might trigger hemorrhagic transformations. Therefore, it is mandatory to develop innovative nanomedicine-based solutions for more efficient and safer thrombolysis with biocompatible and biodegradable thrombus-targeted nanocarrier. Herein, fucoidan-functionalized hydrogel polysaccharide submicroparticles w...
Source: Biomaterials - September 5, 2021 Category: Materials Science Authors: Alina Zenych Charl ène Jacqmarcq Rachida Aid Louise Fournier Laura M Forero Ramirez Fr édéric Chaubet Thomas Bonnard Denis Vivien Didier Letourneur C édric Chauvierre Source Type: research

P2X4R contributes to central disinhibition via TNF- α/TNFR1/GABAaR pathway in post-stroke pain rats
Stroke is the leading cause of adult disability worldwide41. Central post-stroke pain (CPSP) is a chronic neuropathic pain, which is one of the most difficult sequelae of ischemic and hemorrhagic stroke11. This syndrome is characterized by spontaneous or an abnormal sensation secondary to noxious or non-noxious stimuli including spontaneous pain, hyperalgesia, and allodynia17, which localize at one of multiple sites in the somatosensory pathway27. Thalamus stroke is one of the major causes of neuropathic central pain.
Source: The Journal of Pain - March 4, 2021 Category: Materials Science Authors: Jiajie Lu, Xiaoning Guo, Manyun Yan, Xiaqing Yuan, Shujun Chen, Yiqing Wang, Juehua Zhu, Shicun Huang, Haitao Shen, Haiying Li, Qun Xue, Qi Fang, Jianqiang Ni, Lei Gan, Hongru Zhao, Haifeng Lu, Gang Chen Tags: Original Reports Source Type: research