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Stem cells alleviate OGD/R mediated stress response in PC12 cells following a co-culture: modulation of the apoptotic cascade through BDNF-TrkB signaling
Cell Stress Chaperones. 2023 Jan 9. doi: 10.1007/s12192-022-01319-4. Online ahead of print.ABSTRACTApoptosis mediated by endoplasmic reticulum (ER) stress plays a crucial role in several neurovascular disorders, including ischemia/reperfusion injury (I/R injury). Previous in vitro and in vivo studies have suggested that following I/R injury, ER stress is vital for mediating CCAT-enhancer-binding protein homologous protein (CHOP) and caspase-12-dependent apoptosis. However, its modulation in the presence of stem cells and the underlying mechanism of cytoprotection remains elusive. In vivo studies from our lab have reported ...
Source: Cell Stress and Chaperones - January 9, 2023 Category: Cytology Authors: Harpreet Kaur Deepaneeta Sarmah Aishika Datta Anupom Borah Dileep R Yavagal Pallab Bhattacharya Source Type: research

RE-1 silencing transcription factor (REST): a regulator of neuronal development and neuronal/endocrine function
Abstract RE-1 silencing transcription factor (REST) is a transcriptional repressor that has been proposed to function as a master negative regulator of neurogenesis, as REST target genes encode neuronal receptors, ion channels, neuropeptides and synaptic proteins. During neuronal differentiation, REST expression levels are reduced, allowing expression of selected REST target genes. The analysis of neural stem/progenitor cells that are either devoid of REST or overexpress REST revealed that REST is not the master regulator that is solely responsible for the acquisition of the neuronal fate. Rather, REST provides a...
Source: Cell and Tissue Research - January 1, 2015 Category: Cytology Source Type: research

Beneficial Effect of Astragalosides on Stroke Condition Using PC12 Cells under Oxygen Glucose Deprivation and Reperfusion.
In this study, the direct effect of AST against oxygen and glucose deprivation (OGD) including neuronal injury and the underlying mechanisms in vitro were investigated. 5 h OGD followed by 24 h of reperfusion [adding back oxygen and glucose (OGD-R)] was used to induce in vitro ischemia reperfusion injury in differentiated rat pheochromocytoma PC12 cells. AST (1, 100, and 200 µg/mL) were added to the culture after 5 h of the OGD ischemic insult and was present during the reoxygenation phases. A key finding was that OGD-R decreased cell viability, increased lactate dehydrogenase, increased reactive oxygen species, apopt...
Source: Cellular and Molecular Neurobiology - May 8, 2014 Category: Cytology Authors: Chiu BY, Chang CP, Lin JW, Yu JS, Liu WP, Hsu YC, Lin MT Tags: Cell Mol Neurobiol Source Type: research