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Specialty: Cytology
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Total 42 results found since Jan 2013.
Posttreatment with Ospemifene Attenuates Hypoxia- and Ischemia-Induced Apoptosis in Primary Neuronal Cells via Selective Modulation of Estrogen Receptors
Neurotox Res. 2023 May 2. doi: 10.1007/s12640-023-00644-5. Online ahead of print.ABSTRACTStroke and perinatal asphyxia have detrimental effects on neuronal cells, causing millions of deaths worldwide each year. Since currently available therapies are insufficient, there is an urgent need for novel neuroprotective strategies to address the effects of cerebrovascular accidents. One such recent approach is based on the neuroprotective properties of estrogen receptors (ERs). However, activation of ERs by estrogens may contribute to the development of endometriosis or hormone-dependent cancers. Therefore, in this study, we util...
Source: Cell Research - May 2, 2023 Category: Cytology Authors: Bernadeta A Pietrzak Agnieszka Wnuk Karolina Przepi órska Andrzej Łach Ma łgorzata Kajta Source Type: research
A review on the role of SNHG8 in human disorders
Pathol Res Pract. 2023 Apr 7;245:154458. doi: 10.1016/j.prp.2023.154458. Online ahead of print.ABSTRACTSmall nucleolar RNA host gene 8 (SNHG8) is a long non-coding RNA that has physiological roles in epithelial and muscle satellite cells. This lncRNA has been reported to be over-expressed in a variety of cancer cell lines. Its silencing has attenuated tumor growth in animal models of cancers. SNHG8 can be served as a molecular sponge for some miRNAs to regulate their target genes. miR-634/ZBTB20, miR-335-5p/PYGO2, miR588/ATG7, miR-152/c-MET, miR-1270/BACH1, miR-491/PDGFRA, miR-512-5p/TRIM28, miR-149-5p/PPM1F, miR-542-3p/CC...
Source: Cell Research - April 12, 2023 Category: Cytology Authors: Soudeh Ghafouri-Fard Atefeh Harsij Bashdar Mahmud Hussen Mohammad Taheri Seyed Abdulmajid Ayatollahi Source Type: research
Tripartite Motif Protein Family in Central Nervous System Diseases
Cell Mol Neurobiol. 2023 Mar 29. doi: 10.1007/s10571-023-01337-5. Online ahead of print.ABSTRACTTripartite motif (TRIM) protein superfamily is a group of E3 ubiquitin ligases characterized by the conserved RING domain, the B-box domain, and the coiled-coil domain (RBCC). It is widely involved in various physiological and pathological processes, such as intracellular signal transduction, cell cycle regulation, oncogenesis, and innate immune response. Central nervous system (CNS) diseases are composed of encephalopathy and spinal cord diseases, which have a high disability and mortality rate. Patients are often unable to tak...
Source: Cellular and Molecular Neurobiology - March 29, 2023 Category: Cytology Authors: Mengtian Pan Xiang Li Guangchen Xu Xinjuan Tian Yunman Li Weirong Fang Source Type: research
A review on the role of ADAMTS9-AS2 in different disorders
Pathol Res Pract. 2023 Jan 27;243:154346. doi: 10.1016/j.prp.2023.154346. Online ahead of print.ABSTRACTRecent decade has seen a tremendous progress in identification of the role of different long non-coding RNAs (lncRNAs) in human pathologies. ADAMTS9-AS2 is an example of lncRNAs with different roles in human disorders. It is mostly acknowledged as a tumor suppressor lncRNA in different types of cancers. However, it has been reported to be up-regulated in tongue squamous cell carcinoma, salivary adenoid cystic carcinoma and glioblastoma. Moreover, ADAMTS9-AS2 is possibly involved in the pathoetiology of pulpitis, acute is...
Source: Cell Research - February 6, 2023 Category: Cytology Authors: Soudeh Ghafouri-Fard Arian Askari Bashdar Mahmud Hussen Aria Baniahmad Mohammad Taheri Majid Mokhtari Source Type: research
Cumulative Incidence of Thromboembolism and Prognostic Impact of Stroke in < em > BRAF < /em > V600E-mutant Non-small-cell Lung Cancer
CONCLUSION: A substantial proportion of patients with BRAF V600E-mutant lung cancer experienced thromboembolism during their disease course. CRS of undetermined source may predict a worse prognosis in this population.PMID:36697098 | DOI:10.21873/anticanres.16237
Source: Cell Research - January 25, 2023 Category: Cytology Authors: Sho Yamada Akimasa Sekine Eri Hagiwara Yoko Onodera Erina Tabata Satoshi Ikeda Hideya Kitamura Tomohisa Baba Shigeru Komatsu Takashi Ogura Source Type: research
Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
Eur J Med Res. 2022 Nov 4;27(1):232. doi: 10.1186/s40001-022-00833-6.ABSTRACTAngiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorder...
Source: Cell Research - November 5, 2022 Category: Cytology Authors: Ahmad Hoseinzadeh Hamed Ghoddusi Johari Mohammad Hossein Anbardar Lobat Tayebi Ehsan Vafa Milad Abbasi Ahmad Vaez Ali Golchin Ali Mohammad Amani Ali Jangjou Source Type: research
A transcriptomic atlas of drug-induced endothelial dysfunction in human endothelial cells
Drug-induced vascular burden is a critical challenge in both pharmaceutical development and clinical setting. In the past two decades, multiple drugs have been withdrawn from the market due to unanticipated adverse vascular complications, such as the increased risk of myocardial infarction and stroke (e.g., sibutramine and valdecoxib), heart valvular disease (e.g., pergolide and dexfenfluramine), and haemorrhagic stroke (e.g., phenylpropanolamine). Furthermore, many cancer drugs, such as anthracyclines, tyrosine kinase inhibitors (TKIs), and proteasome inhibitors, are also well-known to elicit a broad spectrum of vascular dysfunctions [1].
Source: Journal of Molecular and Cellular Cardiology - October 27, 2022 Category: Cytology Authors: Chengyi Tu, Yu Liu, Damon R. Williams, Joseph C. Wu Tags: Letter to the Editor Source Type: research
Protein Biomarkers in Blood Reflect the Interrelationships Between Stroke Outcome, Inflammation, Coagulation, Adhesion, Senescence and Cancer
Cell Mol Neurobiol. 2022 Aug 11:1-12. doi: 10.1007/s10571-022-01260-1. Online ahead of print.ABSTRACTThe most important predictors for outcomes after ischemic stroke, that is, for health deterioration and death, are chronological age and stroke severity; gender, genetics and lifestyle/environmental factors also play a role. Of all these, only the latter can be influenced after the event. Recurrent stroke may be prevented by antiaggregant/anticoagulant therapy, angioplasty of high-grade stenoses, and treatment of cardiovascular risk factors. Blood cell composition and protein biomarkers such as C-reactive protein or interle...
Source: Cellular and Molecular Neurobiology - August 11, 2022 Category: Cytology Authors: Georg Fuellen Uwe Walter Larissa Henze Jan B öhmert Daniel Palmer Soyoung Lee Clemens A Schmitt Henrik Rudolf Axel Kowald Source Type: research
Protocadherin gamma C3: a new player in regulating vascular barrier function
Neural Regen Res. 2023 Jan;18(1):68-73.ABSTRACTDefects in the endothelial cell barrier accompany diverse malfunctions of the central nervous system such as neurodegenerative diseases, stroke, traumatic brain injury, and systemic diseases such as sepsis, viral and bacterial infections, and cancer. Compromised endothelial sealing leads to leaking blood vessels, followed by vasogenic edema. Brain edema as the most common complication caused by stroke and traumatic brain injury is the leading cause of death. Brain microvascular endothelial cells, together with astrocytes, pericytes, microglia, and neurons form a selective barr...
Source: Cell Research - July 8, 2022 Category: Cytology Authors: Victoria Kaupp Kinga G Blecharz-Lang Christina Dilling Patrick Meybohm Malgorzata Burek Source Type: research
β-Actin: An Emerging Biomarker in Ischemic Stroke
We examined human and preclinical studies to gain a comprehensive understanding of the literature on the subject. Most relevant literatures focus on preclinical research, and pay more attention to the role of β-actin in the process of cerebral ischemia, but some recent literatures reported that in human studies, serum β-actin increased significantly in the early stage of acute cerebral ischemia. This review will investigate the basic biology of β-actin, pay attention to the potential role of serum β-actin as an early diagnostic blood biomarker of ischemic stroke, and explore its potential mechanism in ischemic stroke a...
Source: Cellular and Molecular Neurobiology - May 13, 2022 Category: Cytology Authors: Jiaqian Li Fangyu Dai Xuelian Kou Bin Wu Jie Xu Songbin He Source Type: research
