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Specialty: Lipidology
Condition: Cholesterol
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Total 29 results found since Jan 2013.
Prevalence, pattern, and correlates of dyslipidemia in Bangladeshi individuals
Stroke and ischaemic heart disease accounted for the top two causes of death in Bangladesh1. Dyslipidemia is identified as a significant independent modifiable risk factor for cardiovascular diseases (CVDs) that has been strongly connected to the pathophysiology of CVDs2. Dyslipidemia is defined as the presence of abnormal blood concentrations of one or more of the following lipids (fat): total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TG)3.
Source: Journal of Clinical Lipidology - September 16, 2023 Category: Lipidology Authors: Md Tauhidul Islam, Md Taqbir Us Samad Talha, Sabit Saad Shafiq, Tapas Mazumder, Rajat Das Gupta, Shahjahan Siraj Tags: Original Research Source Type: research
Admission LDL-cholesterol, statin pretreatment and early outcomes in acute ischemic stroke
Elevated LDL-cholesterol (LDL-C) levels increase the risk of stroke and vascular events. Initiation and maintenance of lipid-lowering therapy after acute ischemic stroke (AIS) appears to be guided by LDL-C levels.1 The EUROASPIRE III stroke-specific module shows that secondary prevention and risk factor control in patients after ischemic stroke need to be improved since about half of patients are not achieving target lipid levels defined in European guidelines.2 However, lower levels of LDL-C are paradoxically associated with increased mortality in ST elevation myocardial infarction patients.
Source: Journal of Clinical Lipidology - August 7, 2023 Category: Lipidology Authors: Joon-Tae Kim, Ji Sung Lee, Beom Joon Kim, Jihoon Kang, Keon-Joo Lee, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Tai Hwan Park, Kyungbok Lee, Jun Lee, Keun-Sik Hong, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung Tags: Original Research Source Type: research
Primary Prevention of Stroke is Strongly Correlated with Low-Density-Lipoprotein Cholesterol Reduction: A Meta-Regression Analysis
Statins have become the cornerstone of therapy for both primary and secondary prevention of cardiovascular (CV) and cerebrovascular diseases (CVD). Numerous studies and meta-analyses have documented these benefits independent of low-density-lipoprotein cholesterol (LDL-C) lowering. There are discrepant reports regarding the dependence of the stroke benefits on the baseline LDL-C levels. The relevance of LDL-C reduction from baseline in the era of pleiotropic benefits needs further exploration, especially, while comparing the primary stroke cohort with the secondary stroke prevention cohort.
Source: Journal of Clinical Lipidology - July 1, 2023 Category: Lipidology Authors: Samit Ghosal, Krishna G Seshadri Tags: Lipid Management in Special Populations Source Type: research
Prevalence of Lipoprotein(a) Measurements in Patients with or at Risk of Cardiovascular Disease
Elevated lipoprotein(a) [Lp(a)] is an atherogenic, cholesterol-containing, genetically-determined, independent risk factor for ischemic cardiovascular disease outcomes. In clinical settings, elevated serum Lp(a) predicts increased myocardial infarction, stroke, peripheral arterial disease, and aortic valve stenosis risk. Knowledge of a patient's Lp(a) may modify management, including a lower low-density lipoprotein cholesterol (LDL-C) goal and consideration of using a PCSK9 inhibitor.
Source: Journal of Clinical Lipidology - July 1, 2023 Category: Lipidology Authors: Bhavana Upadhyaya, Robert C. Block, Ying Wang, Jeffrey T. Bruckel Tags: Epidemiology of Cardiovascular Disease Source Type: research
Recommended and Observed Statin Use among U.S. Adults – National Health and Nutrition Examination Survey, 2011-2018
Heart disease and stroke are the first and fifth leading causes of death in the United States.1 A leading risk factor for both conditions, high blood cholesterol levels are positively associated with atherosclerotic cardiovascular disease (ASCVD).2-5 The 2013 American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults (2013 Cholesterol Guideline) eliminated specific LDL-c treatment targets, shifted treatment focus to use of HMG-CoA reductase inhibitors (statins), identified four patient groups most likely to bene...
Source: Journal of Clinical Lipidology - December 24, 2022 Category: Lipidology Authors: Angela M. Thompson-Paul, Cathleen Gillespie, Hilary K. Wall, Fleetwood Loustalot, Laurence Sperling, Yuling Hong Tags: Original Research Source Type: research
Statin therapy for primary prevention in men: What is the role for coronary artery calcium?
Statin therapy is widely prescribed for patients with established ASCVD (secondary prevention). Meta-analysis of randomized clinical trials (RCTs) show conclusively that statins substantially reduce recurrent major ASCVD events (myocardial infarction and stroke)1. More problematic is use of statins for patients without ASCVD (primary prevention). RCTs clearly demonstrate that statins can lower ASCVD for primary prevention in patients at higher risk for future vascular events2-4; however, the number needed to treat (NNT) to prevent one ASCVD event is much higher for primary prevention than for secondary prevention.
Source: Journal of Clinical Lipidology - November 23, 2022 Category: Lipidology Authors: Scott M. Grundy, Jijia Wong, Gloria L. Vega Source Type: research
Lipid levels, apolipoproteins, and risk of incident atrial fibrillation in men: A report from the Kuopio Ischaemic Heart Disease Risk Factor Study (KIHD)
Atrial fibrillation (AF) is the most common of all sustained cardiac arrhythmias, with an estimated 6 –12 million people worldwide suffering from this condition in the US by 2050 and 17.9 million people in Europe by 20601. AF patients are at higher risk of cardiovascular disease, including congestive heart failure and stroke, and total and cardiac mortality2-4. Dyslipidemia [abnormal level of trig lycerides (TG) and/or total cholesterol (TC)] and dyslipoproteinemia [abnormal level of lipoproteins, e.g.
Source: Journal of Clinical Lipidology - April 23, 2022 Category: Lipidology Authors: Behnam Tajik, Tomi-Pekka Tuomainen, Rand Jarroch, Jussi Kauhanen, Gregory Y.H. Lip, Masoud Isanejad Tags: Journal of Clinical Lipidology Source Type: research
A cohort study on risk factors of high-density lipoprotein cholesterol hypolipidemia among urban Chinese adults
High-density lipoprotein cholesterol (HDL-C) hypolipidemia, a major type of dyslipidemia, has been associated with many kinds of diseases, such as stroke, coronary heart disease, obesity and diabetes, and has ...
Source: Lipids in Health and Disease - February 22, 2021 Category: Lipidology Authors: Fang Tang, Jian Wang, Stephen Nicholas, Dongfu Qian and Rugang Liu Tags: Research Source Type: research
Case Report: 68 yo Chinese-American woman with high HDL-C and ischemic stroke attributed to intracranial atherosclerotic stenosis
Atherosclerotic cardiovascular disease (ASCVD) events are the most common cause of death in the United States and for most individuals who experience these events, may be predicted by risk identification tools. ASCVD risk calculators enable a clinician-patient discussion and the presence of risk-enhancing factors may further inform decision-making with respect to preventive pharmacotherapy, especially statin prescription. In cases where the decision of whether to treat with medicine is unclear, coronary artery calcium scoring by computed tomography offers enhanced risk stratification and may allow both clinicians and patie...
Source: Journal of Clinical Lipidology - January 27, 2021 Category: Lipidology Authors: Jan Gong, Stephanie Byers Asher, Brett Cucchiara, Marina Cuchel, Daniel Soffer Tags: Case Report Source Type: research
Association between carotid intima media thickness and small dense low-density lipoprotein cholesterol in acute ischaemic stroke
This study is trying to explore the association betwee...
Source: Lipids in Health and Disease - July 28, 2020 Category: Lipidology Authors: Peiyang Zhou, Yan Shen, Lingyun Wang, Zhihua Cao, Wenmin Feng, Jincheng Liu, Lijun Wang, Peng Meng, Jinbo Yang, Wang-Yang Xu and Ping Gao Tags: Research Source Type: research
Relationship between the non-HDLc-to-HDLc ratio and carotid plaques in a high stroke risk population: a cross-sectional study in China
This study...
Source: Lipids in Health and Disease - July 13, 2020 Category: Lipidology Authors: Yan Liu, Zhenwen Zhang, Binlan Xia, Liping Wang, Hengzhong Zhang, Yan Zhu, Chao Liu and Bin Song Tags: Research Source Type: research
Case Report: Acute Stroke Due to Cerebrovascular Atherosclerosis in Chinese-american Woman with Extremely High Level of High Density Lipoprotein-cholesterol (HDL-C) and Coronary Artery Calcium Score Equal Zero
Nothing to disclose.
Source: Journal of Clinical Lipidology - June 30, 2020 Category: Lipidology Authors: Jan Gong, Daniel Soffer Tags: Lipid Management in Special Populations Source Type: research
Low-density Lipoprotein Cholesterol Levels Among Individuals Experiencing Statin-Associated Symptoms: Data from the REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Guidelines recommend adults who discontinue statin therapy due to statin-associated symptoms be re-initiated. Low-density lipoprotein cholesterol (LDL-C) levels achieved after statin re-initiation are unknown.
Source: Journal of Clinical Lipidology - June 16, 2020 Category: Lipidology Authors: Rikki M. Tanner, Lisandro D. Colantonio, Meredith L. Kilgore, Matthew T. Mefford, Dayl T. Chachappan, Katherine E. Mues, Monika M. Safford, Robert S. Rosenson, Paul Muntner Tags: Original Research Source Type: research
Cholesterol reducer and thrombolytic therapy in acute ischemic stroke patients
Specific clinical risk factors may contribute to improving or worsening neurological functions in acute ischemic stroke (AIS) patients pre-treated with a combined cholesterol reducer and recombinant tissue pla...
Source: Lipids in Health and Disease - May 6, 2020 Category: Lipidology Authors: Nicolas Poupore, Dan Strat, Tristan Mackey, Katherine Brown, Ashley Snell and Thomas I. Nathaniel Tags: Research Source Type: research
The LDL cholesterol in stroke limbo: how low can we go?
No abstract available
Source: Current Opinion in Lipidology - May 1, 2020 Category: Lipidology Tags: BIMONTHLY UPDATE: Edited by Alan Rees Source Type: research
