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Diseases Neglected by the Media in Espírito Santo, Brazil in 2011–2012
Conclusions Media visibility acts as a strategy for legitimising priorities and contextualizing various realities. Therefore, we propose that the health problems identified should enter the public agenda and begin to be recognized as legitimate demands.
Source: PLoS Neglected Tropical Diseases - April 25, 2016 Category: Tropical Medicine Authors: Aline Guio Cavaca Source Type: research

Zika Virus Emergence and Expansion: Lessons Learned from Dengue and Chikungunya May Not Provide All the Answers.
Abstract Following the emergence of Zika in the past decade, there are lessons to be learned from similar emergence events of dengue (DENV) and chikungunya (CHIKV). Specifically, as Zika emerges in the Americas there is a natural tendency to apply the knowledge base of DENV and CHIKV to mitigation and control of a virus with such a similar transmission system. However, there are marked differences that may preclude such broad stroke application of this knowledge base without making potentially faulty assumptions. Herein, Zika virus (ZIKV) transmission is reviewed, and the commonalities among these three arboviruse...
Source: The American Journal of Tropical Medicine and Hygiene - February 22, 2016 Category: Tropical Medicine Authors: Christofferson RC Tags: Am J Trop Med Hyg Source Type: research

Relevance of Non-communicable Comorbidities for the Development of the Severe Forms of Dengue: A Systematic Literature Review
This study systematically reviews the evidence related to comorbidities and dengue. A systematic literature review was performed in five databases (EMBASE, PUBMED, Global Health, SciELO, Cochrane) and grey literature for full-text articles since its inceptions until October 10, 2015. A total of 230 articles were retrieved. Sixteen studies were analysed after applying all inclusion and exclusion criteria. Seven case control studies and nine retrospective cohort studies showed that comorbidities may contribute to severe dengue, especially 1) cardiovascular disease, 2) stroke, 3) diabetes, 4) respiratory disease and 5) renal ...
Source: PLoS Neglected Tropical Diseases - January 4, 2016 Category: Tropical Medicine Authors: Joao Toledo et al. Source Type: research

Neuroactive compounds obtained from arthropod venoms as new therapeutic platforms for the treatment of neurological disorders
The impact of neurological disorders in society is growing with alarming estimations for an incidence increase in the next decades. These disorders are generally chronic and can affect individuals early during productive life, imposing real limitations on the performance of their social roles. Patients can have their independence, autonomy, freedom, self-image, and self-confidence affected. In spite of their availability, drugs for the treatment of these disorders are commonly associated with side effects, which can vary in frequency and severity. Currently, no effective cure is known. Nowadays, the biopharmaceutical resea...
Source: Journal of Venomous Animals and Toxins including Tropical Diseases - October 1, 2015 Category: Tropical Medicine Source Type: research

Pilot study of antibodies against varicella zoster virus and human immunodeficiency virus in relation to the risk of developing stroke, nested within a rural cohort in Uganda
ConclusionsThis is the first prospective study to examine a biological measure of exposure to VZV prior to diagnosis of stroke and although we identified no significant association, in this small pilot, with limited characterisation of cases, we cannot exclude the possibility that the virus is causal for a subset. The impact of HIV on risk of stroke has not been well characterised and warrants further study.
Source: Tropical Medicine and International Health - July 23, 2015 Category: Tropical Medicine Authors: Gershim Asiki, Lisa Stockdale, Ivan Kasamba, Tobias Vudriko, Grace Tumwekwase, Tom Johnston, Pontiano Kaleebu, Anatoli Kamali, Janet Seeley, Robert Newton Tags: Original Article Source Type: research

Pilot study of antibodies against Varicella Zoster Virus (VZV) and human immunodeficiency virus (HIV) in relation to the risk of developing stroke, nested within a rural cohort in Uganda
ConclusionsThis is the first prospective study to examine a biological measure of exposure to VZV prior to diagnosis of stroke and although we identified no significant association, in this small pilot, with limited characterisation of cases, we cannot exclude the possibility that the virus is causal for a subset. The impact of HIV on risk of stroke has not been well characterised and warrants further study.This article is protected by copyright. All rights reserved.
Source: Tropical Medicine and International Health - June 17, 2015 Category: Tropical Medicine Authors: Gershim Asiki, Lisa Stockdale, Ivan Kasamba, Tobias Vudriko, Grace Tumwekwase, Tom Johnston, Pontiano Kaleebu, Anatoli Kamali, Janet Seeley, Robert Newton Tags: Original Article Source Type: research

Trends in stroke admissions to a Tanzanian hospital over four decades: A retrospective audit
ConclusionsThe burden of stroke on health services in Tanzania appears to have increased rapidly. If this increase is to be slowed then sustainable primary preventative measures to target known stroke risk factors will be required.This article is protected by copyright. All rights reserved.
Source: Tropical Medicine and International Health - May 16, 2015 Category: Tropical Medicine Authors: Richard W. Walker, Rachel Viney, Laura Green, Manasseh Mawanswila, Venance P. Maro, Charlotte Gjertsen, Hannah Godfrey, Rosanna Smailes, William K. Gray Tags: Original Article Source Type: research

AKT Network of Genes and Impaired Myocardial Contractility During Murine Acute Chagasic Myocarditis.
Abstract Chagasic disease is associated with high morbidity in Latin America. Acute Chagasic myocarditis is consistently found in acute infections, but little is known about its contribution to chronic cardiomyopathy. The aim of the study was to phenotypically characterize two strains of mice with differential Chagas infection susceptibility and correlate strain myocarditis phenotypes with heart tissue gene expression. C57BL/6J and Balb/c mice were injected intraperitoneally with 0 or 150-200 tissue-derived trypomastigotes (Tulahuen strain). Echocardiograms, brain natriuretic peptide, and troponin were measured. H...
Source: The American Journal of Tropical Medicine and Hygiene - January 12, 2015 Category: Tropical Medicine Authors: Henao-Martínez AF, Agler AH, Watson AM, Hennessy C, Davidson E, Demos-Davies K, McKinsey TA, Wilson M, Schwartz DA, Yang IV Tags: Am J Trop Med Hyg Source Type: research

Duration of residence and disease occurrence among refugees and family reunited immigrants: test of the ‘healthy migrant effect’ hypothesis
ConclusionOur analyses of the effect of duration of residence on disease occurrence among migrants imply that, when explaining migrants' advantageous health outcomes, the ruling theory of the HME should be used with caution, and other explanatory models should be included.
Source: Tropical Medicine and International Health - May 30, 2014 Category: Tropical Medicine Authors: Marie Norredam, Charles Agyemang, Oluf K. Hoejbjerg Hansen, Jørgen H. Petersen, Stine Byberg, Allan Krasnik, Anton E. Kunst Tags: Original Article Source Type: research

The Importance of Neurocysticercosis in Stroke in Rural Areas of a Developing Latin American Country.
This study suggests that NCC is not responsible for the increasing burden of stroke in rural areas of developing countries. PMID: 23836572 [PubMed - as supplied by publisher]
Source: The American Journal of Tropical Medicine and Hygiene - July 8, 2013 Category: Tropical Medicine Authors: Del Brutto OH, Lama J, for the Atahualpa Project Investigators Tags: Am J Trop Med Hyg Source Type: research

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