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Genotype and Phenotype of Adenosine Deaminase 2 Deficiency: a Report from Saudi Arabia
AbstractAdenosine deaminase 2 deficiency (DADA2), a rare and potentially fatal systemic autoinflammatory disease, is characterized by low or lack of ADA2 activity due toADA2 mutations. DADA2 symptoms are variable and include vasculitis, immunodeficiency, and cytopenia. Minimal data are available from Saudi Arabia. This retrospective study conducted at seven major tertiary medical centers examined the phenotypic and genotypic variabilities, clinical and diagnostic findings, and treatment outcomes among 20 Saudi patients with DADA2 from 14 families. The median age of the study cohort was 9.5  years (4–26 years). The clin...
Source: Journal of Clinical Immunology - October 14, 2022 Category: Allergy & Immunology Source Type: research

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil
CONCLUSIONS: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased ri sk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 8, 2018 Category: Tropical Medicine Source Type: research

Blood transfusion services for patients with sickle cell disease in Nigeria
Conclusion Current efforts of Nigerian public hospitals to provide safe blood and CTT fall short of best practice. Provision of apheresis machines, improvement of voluntary non-remunerated donor drive, screening for red cell antigens and antibodies, and availability of iron chelators would significantly improve SCD care in Nigeria.
Source: International Health - September 27, 2016 Category: Global & Universal Authors: Diaku-Akinwumi, I. N., Abubakar, S. B., Adegoke, S. A., Adeleke, S., Adewoye, O., Adeyemo, T., Akinbami, A., Akinola, N. O., Akinsulie, A., Akinyoola, A., Aneke, J., Awwalu, S., Babadoko, A., Brown, B., Ejike, O., Emodi, I., George, I., Girei, A., Hassan, Tags: Original Article Source Type: research