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Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
Basic Res Cardiol. 2023 Sep 9;118(1):37. doi: 10.1007/s00395-023-01008-y.ABSTRACTThe ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and myocardial perfusion without affecting blood pressure in humans, but the cardiovascular sites of action remain obscure. Here, we test the hypothesis in rats that 3-OHB acts directly on the heart to increase cardiac contractility and directly on blood vessels to lower systemic vascular resistance. We investigate effects of 3-OHB on (a) in vivo hemodynamics using echocardiography and invasive blood pressure measurements, (b) isolated perfused hearts in Langendorff systems, an...
Source: Biomed Res - September 9, 2023 Category: Research Authors: Casper Homilius Jacob Marthinsen Seefeldt Julie S ørensen Axelsen Tina Myhre Pedersen Trine Monberg S ørensen Roni Nielsen Henrik Wiggers Jakob Hansen Vladimir V Matchkov Hans Erik B øtker Ebbe Boedtkjer Source Type: research

Left ventricular assist device implantation combined with hemiarch replacement for severe aortic atherosclerosis
J Thorac Dis. 2023 Jul 31;15(7):3979-3983. doi: 10.21037/jtd-23-255. Epub 2023 Jul 6.ABSTRACTImplantation of the left ventricular assist device (LVAD) has emerged as a widely employed therapeutic approach for specifically chosen individuals suffering from severe heart failure. Stroke is a well-known complication of LVAD implantation. Concomitant aortic surgeries in patients requiring LVAD implantation to avoid outflow graft anastomosis to a severe atherosclerotic aorta are unknown. We illustrate a successful LVAD implantation with hemiarch replacement for severe aortic atherosclerosis to decrease the risk of postoperative ...
Source: Atherosclerosis - August 10, 2023 Category: Cardiology Authors: June Lee Seok Beom Hong Yong Han Kim Hwan Wook Kim Do Yeon Kim Source Type: research

Complementary prognostic value of stress perfusion imaging and global coronary flow reserve derived from cardiovascular magnetic resonance: a long-term cohort study
CONCLUSIONS: During long-term follow-up, stress perfusion CMR and global CFR derived from CS flow measurement provided complementary prognostic value for prediction of cardiovascular events. Microvascular dysfunction or diffuse atherosclerosis as shown by impaired global CFR may play a role as important as that of ischemia due to epicardial coronary stenosis in the risk stratification of CAD patients.PMID:36927677 | PMC:PMC10018821 | DOI:10.1186/s12968-023-00930-3
Source: Atherosclerosis - March 17, 2023 Category: Cardiology Authors: Satoshi Nakamura Masaki Ishida Kei Nakata Masafumi Takafuji Shiro Nakamori Tairo Kurita Haruno Ito Kaoru Dohi Hajime Sakuma Source Type: research

Midodrine and albumin as a possible "winning pair" in managing paracentesis-induced circulatory dysfunction: a clinical case report
CONCLUSIONS: Our clinical case wants to show how not all PICDs are secondary to hepatic dysfunctions with Midodrine playing a possible therapeutic role by counteracting the pathophysiological mechanism in a rapid and non-invasive way, representing a valid therapeutic option in adjunction to albumin.PMID:36591858 | DOI:10.26355/eurrev_202212_30680
Source: European Review for Medical and Pharmacological Sciences - January 2, 2023 Category: Drugs & Pharmacology Authors: B Marigliano M Internullo L Scuro A Tavanti L R Del Vecchio M B Schito G M Colombo E Guglielmelli Source Type: research

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