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Non-calcified active atherosclerosis plaque detection with 18F-NaF and 18F-FDG PET/CT dynamic imaging
This study was aimed to assess the behavior of 18F-sodium fluoride (18F-NaF) and 18F-fluorodeoxyglucose (18F-FDG) uptake in the aorta and iliac arteries as a function of plaque density on CT images. We report metabolically active artery plaques associated to inflammation in the absence of calcification. 18 elderly volunteers were recruited and imaged with computed tomography (CT) and positron emission tomography (PET) with 18F-NaF and 18F-FDG. A total of 1338 arterial segments were analyzed, 766 were non-calcified and 572 had calcifications. For both 18F-NaF and 18F-FDG, the mean SUV values were found statistically signifi...
Source: Atherosclerosis - January 30, 2023 Category: Cardiology Authors: Abdelillah Douhi Mamdouh S Al-Enezi Nousra Berrahmoune Abdelouahed Khalil Tamas Fulop Michel Nguyen Eric Turcotte Étienne Croteau M'hamed Bentourkia Source Type: research

The uptake pattern of 18F-sodium fluoride radioligand in brain tissue after cerebral infarction
In this study, we measured the maximum and mean standardized uptake value (SUVmax and SUVmean) of NaF uptake level in the cerebral infarct region between lesions with and without diffusion weighted image (DWI) positivity, indicating acute ischemic cell death. Correlation analysis was performed between NaF uptake levels and imaging and clinical variables, including neurological severity. The NaF uptake levels were significantly higher in DWI positive lesions than in negative lesions (SUVmax: 2.0 [0.60-4.2] versus 0.20 [0.10-0.40], p = 0.021 by Mann-Whitney U test). The intensity of NaF uptake (SUVmax) was significantly corr...
Source: Atherosclerosis - December 29, 2022 Category: Cardiology Authors: Jeong-Min Kim Reeree Lee Hae-Bong Jeong Kwang-Yeol Park Ju Won Seok Source Type: research

NaF-PET shows bone formation in psoriatic arthritis patients
F-18 sodium fluoride (NaF) PET/CT may be a valuable tool for imaging patient...Read more on AuntMinnie.comRelated Reading: NaF-PET reveals aortic wall injuries NaF-PET scans reveal plaque -- and possible risk of stroke NaF-PET/CT does well in detecting prostate metastases NaF-PET/CT rarely finds prostate cancer bone metastases AI algorithm can classify bone lesions on PET/CT images
Source: AuntMinnie.com Headlines - November 18, 2022 Category: Radiology Source Type: news

Common carotid segmentation in < sup > 18 < /sup > F-sodium fluoride PET/CT scans: head-to-head comparison of artificial intelligence-based and manual method
CONCLUSIONS: CNN-based segmentation was much faster and provided SUVmean values virtually identical to manually obtained ones, suggesting CNN-based analysis as a promising substitute of slow and cumbersome manual processing. This article is protected by copyright. All rights reserved.PMID:36331059 | DOI:10.1111/cpf.12793
Source: Atherosclerosis - November 4, 2022 Category: Cardiology Authors: Reza Piri Yaran Hamakan Ask Vang Lars Edenbrandt M åns Larsson Olof Enqvist Oke Gerke Poul Flemming H øilund-Carlsen Source Type: research

Highly efficient radiosynthesis and biological evaluation of 18Fsafinamide, a radiolabelled anti-parkinsonian drug for PET imaging
ChemMedChem. 2022 Sep 6. doi: 10.1002/cmdc.202200472. Online ahead of print.ABSTRACTAs an add-on drug approved for Parkinson's disease treatment, safinamide has multiple functions, such as selective and reversible monoamine oxidase-B inhibition, voltage-sensitive sodium/potassium channel blockage, and glutamate release inhibition. Meanwhile, safinamide shows tremendous therapeutic potential in the context of other central nervous system diseases (e.g., ischaemic stroke, amyotrophic lateral sclerosis, depression, etc.). In this work, [18F]safinamide, which is safinamide labelled by the positron-emitting radionuclide [18F]fl...
Source: ChemMedChem - September 7, 2022 Category: Chemistry Authors: Yangyang Xu Peili Cen Lijuan Ma Mei Tian Xue Zhang Qinghua Zhang Kaiwu Yu Hong Zhang Wangjun Gu Qinggang He Source Type: research

NaF-PET reveals aortic wall injuries
PET imaging with F-18 sodium fluoride (NaF) can detect activity related to tear...Read more on AuntMinnie.comRelated Reading: NaF-PET scans reveal plaque -- and possible risk of stroke Viz.ai to add Avicenna.ai software to platform NaF-PET/CT does well in detecting prostate metastases NaF-PET/CT rarely finds prostate cancer bone metastases Can deep learning monitor lesions on F-18 NaF PET/CT?
Source: AuntMinnie.com Headlines - March 22, 2022 Category: Radiology Source Type: news

Thoracic Aortic < sup > 18 < /sup > F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease
CONCLUSIONS: In patients with established cardiovascular disease, thoracic aortic 18F-sodium fluoride activity is associated with the progression of atherosclerosis and future ischemic stroke. Arterial 18F-sodium fluoride activity identifies localized areas of atherosclerotic disease activity that are directly linked to disease progression and downstream regional clinical atherothrombotic events. (DIAMOND - Dual Antiplatelet Therapy to Reduce Myocardial Injury [DIAMOND], NCT02110303; Study Investigating the Effect of Drugs Used to Treat Osteoporosis on the Progression of Calcific Aortic Stenosis [SALTIRE II], NCT02132026; ...
Source: Atherosclerosis - February 20, 2022 Category: Cardiology Authors: Alexander J Fletcher Yong Y Tew Evangelos Tzolos Shruti S Joshi Jakub Kaczynski Jennifer Nash Samuel Debono Maria Lembo Jacek Kwiecinski Rong Bing Maaz B J Syed Mhairi K Doris Edwin J R van Beek Alistair J Moss William S Jenkins Niki L Walker Nikhil V Jos Source Type: research

Two-year change in 18F-sodium fluoride uptake in the carotid arteries of healthy subjects and angina pectoris patients
Conclusions: Slightly higher NaF uptake in the angina group indicated more ongoing carotid microcalcification at both time points in patients than in healthy subjects. The 2-year changes were very small in both groups, albeit with a tendency of slight decreases among healthy controls, suggesting a more dynamic, waxing and waning, process in these compared to a slow, but more consistent, progression in angina patients despite statin therapy in half of these.
Source: Journal of Nuclear Medicine - May 18, 2021 Category: Nuclear Medicine Authors: Piri, R., Lici, G., Riyahimanesh, P., Gerke, O., Alavi, A., Flemming Hoilund-Carlsen, P. Tags: Clinical Science Source Type: research

Quantifying microcalcification activity in the thoracic aorta
ConclusionsAMA is a simple, rapid and reproducible method of quantifying global18F-NaF uptake across the ascending aorta and aortic arch that correlates with cardiovascular risk scores.
Source: Journal of Nuclear Cardiology - January 20, 2021 Category: Nuclear Medicine Source Type: research

Early Experience with 18F-Fluoride Positron Emission Tomography- Magnetic Resonance Imaging in Patients with Symptomatic Carotid Artery Stenosis Undergoing Carotid Endarterectomy
Introduction: Carotid endarterectomy is an established surgical intervention that is associatedwith a reduction in the future risk of stroke in symptomatic patients. However, the identification of culprit carotid plaque remains challenging for number of reasons including the suboptimal evaluation of carotid plaque morphology, disease activity and future stroke risk stratification.
Source: European Journal of Vascular and Endovascular Surgery - November 30, 2019 Category: Surgery Authors: Jakub Kaczynski, Michelle Williams, Rachael Forsythe, Andrew Tambyraja, Christophe Lucatelli, Edwin van Beek, William Whiteley, David Newby Source Type: research

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