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Post-stroke Constraint-induced Movement Therapy Increases Functional Recovery, Angiogenesis, and Neurogenesis with Enhanced Expression of HIF-1 α and VEGF.
CONCLUSIONS: CIMT-induced neuroprotection and functional recovery following cerebral ischemia were possibly mediated by an increase in endogenous HIF-1α and VEGF expression with subsequent neurogenesis and angiogenesis. PMID: 29189156 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - November 28, 2017 Category: Neurology Authors: Li C, Zhang B, Zhu Y, Li Y, Liu P, Gao B, Tian S, Du L, Bai YL Tags: Curr Neurovasc Res Source Type: research

Forced limb-use enhanced neurogenesis and behavioral recovery after stroke in the aged rats
We examined whether forced limb-use which mimicked CIMT could influence ischemia-induced neurogenesis, apoptosis and behavioral recovery in the aged rats. Aged rats were divided into a sham group, an ischemia group, and an ischemia group with forced limb-use. Focal cerebral ischemia was induced by injection of endothelin-1. Forced limb-use began on post-stroke day 7 by fitting a plaster cast around the unimpaired upper limbs of rats for 3weeks. Behavioral recovery was evaluated by tapered/ledged beam-walking test on postoperative day 32. The expression of doublecortin, neuronal nuclei, glial fibrillary acidic protein and I...
Source: Neuroscience - December 25, 2014 Category: Neuroscience Source Type: research

Forced arm use is superior to voluntary training for motor recovery and brain plasticity after cortical ischemia in rats
Conclusions We show that physical training after photothrombotic stroke significantly and permanently improves functional recovery after stroke, and that forced arm training is clearly superior to voluntary running training. The behavioral outcomes seen correlate with patterns and extent of gene expression changes in all brain areas examined. We propose that physical training induces a fundamental change in plasticity-relevant gene expression in several brain regions that enables recovery processes. These results contribute to the debate on optimal rehabilitation strategies, and provide a valuable source of mole...
Source: Experimental and Translational Stroke Medicine - February 14, 2014 Category: Neurology Source Type: research