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Role of Bariatric Surgery in Managing Macrovascular Complications of Obesity-Related Type 2 Diabetes
Reducing the risk of macrovascular events, including myocardial infarction and stroke, is a major goal when treating diabetes. Despite this focus, of the major randomized trials used to support current diabetes guidelines (ACCORD, ADVANCE, UKPDS 33, UKPDS 34, VADT), none showed reductions in macrovascular events when the trial results were first reported. For example, UKPDS is still frequently cited in support of aggressive glucose lowering, yet when the primary outcome data were presented in 1998, the results showed no difference between groups in terms of reducing the risk of all-cause mortality (relative risk [RR], 0.94...
Source: JAMA - Journal of the American Medical Association - September 2, 2019 Category: General Medicine Source Type: research

Bile acids and their effects on diabetes
AbstractDiabetes is a widespread, rapidly increasing metabolic disease that is driven by hyperglycemia. Early glycemic control is of primary importance to avoid vascular complications including development of retinal disorders leading to blindness, end-stage renal disease, and accelerated atherosclerosis with a higher risk of myocardial infarction, stroke and limb amputations. Even after hyperglycemia has been brought under control, “metabolic memory,” a cluster of irreversible metabolic changes that allow diabetes to progress, may persist depending on the duration of hyperglycemia. Manipulation of bile acid (BA) recep...
Source: Frontiers of Medicine - October 10, 2018 Category: General Medicine Source Type: research