Stroke RSS

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Source: Brain Research Bulletin
Therapy: Stem Cell Therapy

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Total 23 results found since Jan 2013.

Protective Effects of Mesenchymal Stem Cells Overexpressing Extracellular Regulating Kinase 1/2 Against Stroke in Rats.
CONCLUSION: ERK/MSCs transplantation showed better functional recovery after stroke in rats, likely in part through enhancing survival of MSCs and possibly by modulating the proliferation, neuronal de-differentiation and neuroinflammation. PMID: 31002912 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - April 15, 2019 Category: Neurology Authors: Gao X, Wu D, Dou L, Zhang H, Huang L, Zeng J, Zhang Y, Yang C, Li H, Liu L, Ma B, Yuan Q Tags: Brain Res Bull Source Type: research

Mesenchymal stem cells-derived mitochondria transplantation mitigates I/R-induced injury, abolishes I/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model.
Abstract Acute ischemia stroke (AIS) is one of the leading causes of mortality and disability worldwide, and its neurological impacts are devastating and permanent. There is no efficient and real treatment for acute ischemia stroke so far. Therefore, development of efficient therapeutic strategies is under focus of investigations by basic and clinical scientists. Brain is one of the organs with high energy consumption and metabolism. Hence, its functionality is highly dependent on mitochondrial activity and integrity. Therefore, mitochondria play a vital homeostatic role in neurons physiology and mitochondrial dys...
Source: Brain Research Bulletin - September 29, 2020 Category: Neurology Authors: Pourmohammadi-Bejarpasi Z, Roushandeh AM, Saberi A, Kheirandish-Rostami M, Toosi SMR, Jahanian-Najafabadi A, Tomita K, Kuwahara Y, Sato T, Roudkenar MH Tags: Brain Res Bull Source Type: research

miR-145 protects the function of neuronal stem cells through targeting MAPK pathway in the treatment of cerebral ischemic stroke rat.
This study is designed to investigate the function of the miR-145 in the protection of neural stem cells (NSCs) through targeting mitogen-activated protein kinase (MAPK) pathway in the treatment of cerebral ischemic stroke rat. In our study, rat NSCs were selected and cultured in complete medium. The light microscopy was used to observe the morphology of NSCs at different times. The quantitative reverse transcriptase real-time polymerase chain reaction (qRT-PCR) was used to detect the miR-145 and other related mRNAs of the MARK pathway. The Western blotting was used to detect the activation of MAPK pathway and neuronal spe...
Source: Brain Research Bulletin - September 1, 2018 Category: Neurology Authors: Xue WS, Wang N, Wang NY, Ying YF, Xu GH Tags: Brain Res Bull Source Type: research

New progress in the approaches for blood-brain barrier protection in acute ischemic stroke.
Abstract Ischemic stroke is a disease with high morbidity and mortality worldwide, which often places an additional strain on families and society due to the poor prognosis. Blood brain-barrier (BBB) damage is the critical pathological process, which contributes to hemorrhagic transformation (HT) and poor prognosis in cerebral ischemia. Thus, there is a pressing need to seek an approach to ameliorate BBB damage and reduce the HT that can be induced by fibrinolytic therapy involving recombinant tissue plasminogen activator (rtPA) in clinical practice. This review provides an overview of the recent scientific report...
Source: Brain Research Bulletin - November 15, 2018 Category: Neurology Authors: Li Y, Zhong W, Jiang Z, Tang X Tags: Brain Res Bull Source Type: research

Conductive Polymers to Modulate the Post-Stroke Neural Environment.
Abstract Despite the prevalence of stroke, therapies to augment recovery remain limited. Here we focus on the use of conductive polymers for cell delivery, drug release, and electrical stimulation to optimize the post-stroke environment for neural recovery. Conductive polymers and their interactions with in vitro and in vivo neural systems are explored. The ability to continuously modify the neural environment utilizing conductive polymers provides applications in directing stem cell differentiation and increasing neural repair. This exciting class of polymers offers new approaches to optimizing the post-stroke br...
Source: Brain Research Bulletin - March 5, 2019 Category: Neurology Authors: Oh B, George P Tags: Brain Res Bull Source Type: research

GATA3 improves the protective effects of bone marrow-derived mesenchymal stem cells against ischemic stroke induced injury by regulating autophagy through CREG
CONCLUSION: Our results indicated that GATA3 overexpression improved the therapeutic effects of rBMSCs transplantation against ischemic stroke induced injury by regulating autophagy through CREG.PMID:34500038 | DOI:10.1016/j.brainresbull.2021.09.001
Source: Brain Research Bulletin - September 9, 2021 Category: Neurology Authors: Yongchang Li Wei Zhong Qianyi Huang Bing Lang Xiangqi Tang Source Type: research

Bone marrow-mesenchymal stem cells modulate microglial activation in the peri-infarct area in rats during the acute phase of stroke.
CONCLUSION: The transplanted BM-MSCs exerted immunomodulatory effect by inactivating the microglias in the peri-infarct area, at least partially, via the CD200-CD200R1 signaling. PMID: 31589902 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - October 3, 2019 Category: Neurology Authors: Li Z, Ye H, Cai X, Sun W, He B, Yang Z, Xu P Tags: Brain Res Bull Source Type: research

Remote ischemic postconditioning ameliorates stroke injury via the SDF-1 α/CXCR4 signaling axis in rats
Brain Res Bull. 2023 Mar 27:S0361-9230(23)00064-3. doi: 10.1016/j.brainresbull.2023.03.011. Online ahead of print.ABSTRACTRemote Ischemic Postconditioning (RIPostC) has become a research hotspot due to its protective effect on the brain in clinical studies related to ischemic stroke. The purpose of this study is to investigate the protective effect of RIPostC after ischemic stroke in rats. The middle cerebral artery occlusion/reperfusion (MCAO/R) model was established by the wire embolization method. RIPostC was obtained by inducing temporary ischemia in the hind limbs of rats. First, based on the results of short-term beh...
Source: Brain Research Bulletin - March 29, 2023 Category: Neurology Authors: Guannan Jiang Xiang Li Meirong Liu Haiying Li Haitao Shen Juan Liao Wanchun You Qi Fang Gang Chen Source Type: research

Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3
CONCLUSION: BMSC-EVs carrying miR-221-3p protect against IS by inhibiting ATF3. This study may be helpful for exploring therapeutic strategies of IS.PMID:33932490 | DOI:10.1016/j.brainresbull.2021.04.022
Source: Brain Research Bulletin - May 1, 2021 Category: Neurology Authors: Zhibing Ai Chaohui Cheng Lan Zhou Songhe Yin Lei Wang Yong Liu Source Type: research

Effect of Wnt signaling pathway on neurogenesis after cerebral ischemia and its therapeutic potential.
This article describes the composition of Wnt signaling pathway and the process of neurogenesis after cerebral ischemia, and emphatically introduces the recent studies on the mechanisms of this pathway for post-stroke neurogenesis and the therapeutic possibility of activating the pathway to improve neurogenesis after stroke. PMID: 32763283 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - August 3, 2020 Category: Neurology Authors: Xu D, Hou K, Li F, Chen S, Fang W, Li Y Tags: Brain Res Bull Source Type: research

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