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Source: Brain Research
Therapy: Stem Cell Therapy

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Total 32 results found since Jan 2013.

Stem cell-paved biobridges facilitate stem transplant and Host brain cell Interactions for stroke therapy.
Abstract Distinguished by an infarct core encased within a penumbra, stroke remains a primary source of mortality within the United States. While our scientific knowledge regarding the pathology of stroke continues to improve, clinical treatment options for patients suffering from stroke are extremely limited. Tissue plasminogen activator (tPA) remains the sole FDA-approved drug proven to be helpful following stroke. However, due to the need to administer the drug within 4.5h of stroke onset its usefulness is constrained to less than 5% of all patients suffering from ischemic stroke. One experimental therapy for t...
Source: Brain Research - March 11, 2015 Category: Neurology Authors: Duncan K, Gonzales-Portillo GS, Acosta S, Kaneko Y, Borlongan CV, Tajiri N Tags: Brain Res Source Type: research

A comparative study of different doses of bone marrow-derived mesenchymal stem cells improve post-stroke neurological outcomes via intravenous transplantation
CONCLUSIONS: Treatment with MSC restored the sensory and motor function of cerebral ischemia rats, indicating it may be an effective therapy for ischemic stroke.PMID:36379315 | DOI:10.1016/j.brainres.2022.148161
Source: Brain Research - November 15, 2022 Category: Neurology Authors: Yuan Chen Dingguo Peng Jingyi Li Lingling Zhang Jiacheng Chen Lin Wang Yansong Gao Source Type: research

Efficacy of Stem Cell-Based Therapies for Stroke.
Abstract Stroke remains a prevalent disease with limited treatment options. Available treatments offer little in the way of enhancing neurogenesis and recovery. Because of the limitations of available treatments, new therapies for stroke are needed. Stem cell-based therapies for stroke offer promise because of their potential to provide neurorestorative benefits. Stem cell-based therapies aim to promote neurogenesis and replacement of lost neurons or protect surviving neurons in order to improve neurological recovery. The mechanism through which stem cell treatments mediate their therapeutic effect is largely depe...
Source: Brain Research - August 1, 2019 Category: Neurology Authors: Chrostek MR, Fellows EG, Crane AT, Grande AW, Low WC Tags: Brain Res Source Type: research

Rat BM-MSCs secretome alone and in combination with stiripentol and ISRIB, ameliorated microglial activation and apoptosis in experimental stroke
CONCLUSION: STP and trans ISRIB, alone and in combination with rat BM-MSCs secretome, might be considered as potential neuroprotective agents in the acute ischemic stroke (AIS) management.DATA AVAILABILITY STATEMENT: Data will be made available on reasonable request.PMID:37146724 | DOI:10.1016/j.bbr.2023.114471
Source: Brain Research - May 5, 2023 Category: Neurology Authors: Neha Dhir Ashish Jain Amit Raj Sharma Sunil Sharma Dhruv Mahendru Ajay Patial Deepti Malik Ajay Prakash Savita Verma Attri Shalmoli Bhattacharyya Bishan Das Radotra Bikash Medhi Source Type: research

Intranasal administration of Human umbilical cord mesenchymal stem cells-conditioned medium enhances vascular remodeling after stroke.
In this study, we investigated whether intranasal administration of human umbilical cord mesenchymal stem cells (hUCMSCs)-CM has the therapeutic effects in rats after stroke. Adult male rats were subjected to middle cerebral artery occlusion (MCAo) and were treated by intranasal routine with or without hUCMSCs-CM (1ml/kg/d), starting 24h after MCAo and daily for 14 days. Neurological functional tests, blood brain barrier (BBB) leakage were measured. Angiogenesis and angiogenic factor expression were measured by immunohistochemistry, and Western blot, respectively. hUCMSCs-CM treatment of stroke by intranasal routine starti...
Source: Brain Research - August 13, 2015 Category: Neurology Authors: Zhao Q, Hu J, Xiang J, Gu Y, Jin P, Hua F, Zhang Z, Liu Y, Zan K, Zhang Z, Zu J, Yang X, Shi H, Zhu J, Xu Y, Cui G, Ye X Tags: Brain Res Source Type: research

Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Brain Research - January 2, 2023 Category: Neurology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research

iTRAQ-based proteomic analysis after mesenchymal stem cell line transplantation for ischemic stroke.
Abstract Transplantation with mesenchymal stem cells (MSCs) has been reported to promote functional recovery in animal models of ischemic stroke. However, the molecular mechanisms underlying the therapeutic effects of MSC transplantation have been only partially elucidated. The purpose of this study was to comprehensively identify changes in brain proteins in rats treated with MSCs for ischemic stroke, and to explore the multi-target mechanisms of MSCs using a proteomics-based strategy. Twenty-eight proteins were found to be differentially expressed following B10 MSC transplantation in adult male Wistar rats, as a...
Source: Brain Research - May 19, 2020 Category: Neurology Authors: Mitaki S, Nagai A, Wada Y, Onoda K, Md Sheikh A, Adachi E, Matsumoto KI, Yamaguchi S Tags: Brain Res Source Type: research

GATA3 improves the protective effects of bone marrow-derived mesenchymal stem cells against ischemic stroke induced injury by regulating autophagy through CREG
CONCLUSION: Our results indicated that GATA3 overexpression improved the therapeutic effects of rBMSCs transplantation against ischemic stroke induced injury by regulating autophagy through CREG.PMID:34500038 | DOI:10.1016/j.brainresbull.2021.09.001
Source: Brain Research - September 9, 2021 Category: Neurology Authors: Yongchang Li Wei Zhong Qianyi Huang Bing Lang Xiangqi Tang Source Type: research

Up-regulation of SETD3 may contribute to post-stroke depression in rat through negatively regulating VEGF expression
In conclusion, our study indicated that up-regulation of SETD3 contributed to PSD progression in rats through negatively regulating VEGF expression. The findings of this work suggest that SETD3 may be a promising target for treating PSD in the future. AVAILABILITY OF DATA AND MATERIALS: All data generated or analyzed during this study are included in this published article.PMID:34499935 | DOI:10.1016/j.bbr.2021.113564
Source: Brain Research - September 9, 2021 Category: Neurology Authors: Yun Feng Xuebin Li Jie Wang Lanqing Meng Xionglin Tang Xiaohua Wang Jianmin Huang Chongdong Jian Source Type: research

Remote ischemic postconditioning ameliorates stroke injury via the SDF-1 α/CXCR4 signaling axis in rats
Brain Res Bull. 2023 Mar 27:S0361-9230(23)00064-3. doi: 10.1016/j.brainresbull.2023.03.011. Online ahead of print.ABSTRACTRemote Ischemic Postconditioning (RIPostC) has become a research hotspot due to its protective effect on the brain in clinical studies related to ischemic stroke. The purpose of this study is to investigate the protective effect of RIPostC after ischemic stroke in rats. The middle cerebral artery occlusion/reperfusion (MCAO/R) model was established by the wire embolization method. RIPostC was obtained by inducing temporary ischemia in the hind limbs of rats. First, based on the results of short-term beh...
Source: Brain Research - March 29, 2023 Category: Neurology Authors: Guannan Jiang Xiang Li Meirong Liu Haiying Li Haitao Shen Juan Liao Wanchun You Qi Fang Gang Chen Source Type: research

Bone marrow mesenchymal stem cells-derived extracellular vesicles carrying microRNA-221-3p protect against ischemic stroke via ATF3
CONCLUSION: BMSC-EVs carrying miR-221-3p protect against IS by inhibiting ATF3. This study may be helpful for exploring therapeutic strategies of IS.PMID:33932490 | DOI:10.1016/j.brainresbull.2021.04.022
Source: Brain Research - May 1, 2021 Category: Neurology Authors: Zhibing Ai Chaohui Cheng Lan Zhou Songhe Yin Lei Wang Yong Liu Source Type: research