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Specialty: Biology
Source: Life Sciences
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Total 65 results found since Jan 2013.
The beneficial role of early exercise training following stroke and possible mechanisms
Publication date: 1 April 2018 Source:Life Sciences, Volume 198 Author(s): Ying Xing, Si-Dong Yang, Fang Dong, Man-Man Wang, Ya-Shuo Feng, Feng Zhang Exercise training is a regular therapy for stroke patients in clinic. However, whether the early exercise is beneficial for stroke patients is still controversial. The review was performed in databases of OVID, PUBMED, and ISI Web of Science, from respective inception to December 2017. In this review, we summarize the effect of different exercise intensity, initiation time, and style on ischemic stroke. Moreover, the possible mechanism is also discussed. The conclusion is th...
Source: Life Sciences - February 15, 2018 Category: Biology Source Type: research
Whole body hypothermia extends tissue plasminogen activator treatment window in the rat model of embolic stroke
Publication date: Available online 20 February 2020Source: Life SciencesAuthor(s): Mahsa Hassanipour, Mohammadreza Zarisfi, Vahid Ehsani, Mohammad AllahtavakoliAbstractLate treatment with tissue plasminogen activator (tPA) leads to reperfusion injury and poor outcome in ischemic stroke. We have recently shown the beneficial effects of local brain hypothermia after late thrombolysis. Herein, we investigated whether transient whole-body hypothermia was neuroprotective and could prevent the side effects of late tPA therapy at 5.5 h after embolic stroke. After induction of stroke, male rats were randomly assigned into four g...
Source: Life Sciences - February 20, 2020 Category: Biology Source Type: research
The effect of ultrasound for increasing neural differentiation in hBM-MSCs and inducing neurogenesis in ischemic stroke model
This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. Materials and methods hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no exposed one in cell morphology, lactate dehydrogenase (LDH) activity, RT-PCR, and Western blot. In addition, we made stroke model mice by means of the photothrombosis (PT) method and these models were exposed to 0.04MHz ultrasound after hBM-MSCs injection. We compared with sham group in histological and immunohistoch...
Source: Life Sciences - August 30, 2016 Category: Biology Source Type: research
Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke
Publication date: Available online 12 June 2019Source: Life SciencesAuthor(s): Yu-ying Su, Huan-min Li, Zhen-xing Yan, Ming-chun Li, Ji-peng Wei, Wen-xia Zheng, Si-qin Liu, Yi-ting Deng, Hui-fang Xie, Chun-guang LiAbstractAimsIn the present study, we investigated the roles of renin-angiotensin system (RAS) activation and imbalance of matrix metalloproteinase-9 (MMP-9)/tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in cold-induced stroke during chronic hypertension, as well as the protective effects of captopril and recombinant human TIMP-1 (rhTIMP-1).Main methodsRats were randomly assigned to sham; 2-kidney, 2-cli...
Source: Life Sciences - June 12, 2019 Category: Biology Source Type: research
The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to endovascular thrombectomy
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Jenq-Lin Yang, Yun-Ru Yang, Shang-Der ChenAbstractStroke is the major cause of adult disability and the second or third leading cause of death in developed countries. The treatment options for stroke (thrombolysis or thrombectomy) are restricted to a small subset of patients with acute ischemic stroke because of the limited time for an efficacious response and the strict criteria applied to minimize the risk of cerebral hemorrhage. Attempts to develop new treatments, such as neuroprotectants, for acute ischemic stroke have been costly and tim...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research
Dual-modality imaging of endothelial progenitor cells transplanted after ischaemic photothrombotic stroke
Publication date: Available online 2 November 2019Source: Life SciencesAuthor(s): Jie Ding, Yi Zhang, Cong-Xiao Wang, Pei-Cheng Li, Zhen Zhao, Chao Wang, Gao-Jun TengAbstractAimsStroke is a refractory cerebral blood circulation disorder. Endothelial progenitor cells (EPCs) participate in the repair and regeneration of vascular injury through the combination of cell replacement and bystander effects. Here, we evaluated the biological function of EPCs in treating a mouse model of cerebral ischaemic stroke, using dual-mode bioluminescence and magnetic resonance imaging to trace EPCs in vivo.Main methodsWe constructed a viral ...
Source: Life Sciences - November 4, 2019 Category: Biology Source Type: research
Disrupted mitochondrial genes and inflammation following stroke
Publication date: Available online 28 September 2016 Source:Life Sciences Author(s): Whitney S. Gibbs, Rachel A. Weber, Rick G. Schnellmann, DeAnna L. Adkins Aims Determine the subacute time course of mitochondria disruption, cell death, and inflammation in a rat model of unilateral motor cortical ischemic stroke. Main methods Rats received unilateral ischemia of the motor cortex and were tested on behavioral tasks to determine impairments. Animals were euthanized at 24h, 72h and 144h and mRNA expression of key mitochondria proteins and indicators of inflammation, apoptosis and potential regenerative processes in ipsilesi...
Source: Life Sciences - September 28, 2016 Category: Biology Source Type: research
High intensity exercise preconditioning provides differential protection against brain injury following experimental stroke
Publication date: Available online 6 March 2018 Source:Life Sciences Author(s): Rasoul Rezaee, Sanaz Nasoohi, Abbas Haghparast, Fariba Khodagholi, Mohammadreza Bigdeli, Maryam Nourshahi Aims Different modes of physical activity provide cerebrovascular protection against thromboembolic events. Based on recent reports high intensity exercise protocols appear to raise cerebral VEGF levels leading to efficient cerebral angiogenesis. The present study aims to address if moderate continuous training (MCT) and high intensity interval training (HIT) differ in preconditioning against ischemic stroke. Methods Wistar rats were subje...
Source: Life Sciences - March 6, 2018 Category: Biology Source Type: research
Monoacylglycerol lipase inhibitor, JZL-184, confers neuroprotection in the mice middle cerebral artery occlusion model of stroke
Discussion Based on the results, it seems that JZL can be considered as a good candidate for inhibition of stroke secondary injury in the case of delayed treatment.
Source: Life Sciences - March 8, 2018 Category: Biology Source Type: research
High intensity exercise preconditioning provides differential protection against brain injury following experimental stroke
Publication date: 15 August 2018Source: Life Sciences, Volume 207Author(s): Rasoul Rezaei, Sanaz Nasoohi, Abbas Haghparast, Fariba Khodagholi, Mohammad Reza Bigdeli, Maryam NourshahiAbstractAimsDifferent modes of physical activity provide cerebrovascular protection against thromboembolic events. Based on recent reports high intensity exercise protocols appear to raise cerebral VEGF levels leading to efficient cerebral angiogenesis. The present study aims to address if moderate continuous training (MCT) and high intensity interval training (HIT) differ in preconditioning against ischemic stroke.MethodsWistar rats were subje...
Source: Life Sciences - July 5, 2018 Category: Biology Source Type: research
Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke
Publication date: Available online 7 November 2018Source: Life SciencesAuthor(s): Kanta Pravalika, Deepaneeta Sarmah, Harpreet Kaur, Kanchan Vats, Jackson Saraf, Madhuri Wanve, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Kunjan R. Dave, Pallab BhattacharyaAbstractAimStroke is devastating with a limited choice of intervention. Many pharmacological entities are available but none of them have evolved successfully in counteracting the multifaceted molecular alterations following stroke. Myeloperoxidase (MPO) has been reported to play an important role in neuroinflammation following neurodegenerative diseases. Therefore, usi...
Source: Life Sciences - November 8, 2018 Category: Biology Source Type: research
A brain-stellate ganglion-atrium network regulates atrial fibrillation vulnerability through macrophages in acute stroke
Publication date: Available online 9 October 2019Source: Life SciencesAuthor(s): Youcheng Wang, Xiaoxing Xiong, Baojun Xie, Jia Liu, Mei Yang, Junkui Yin, Liuliu Zi, Xi Wang, Yanhong Tang, Congxin Huang, Haixia Fu, Qingyan ZhaoAbstractAimsNew-onset atrial fibrillation (AF) is frequently observed following acute stroke. The aim of this study was to investigate the effects of the brain-stellate ganglion-atrium network on AF vulnerability in a canine model with acute middle cerebral artery occlusion (MCAO).Materials and methodsTwenty-six dogs were randomly divided into the sham-operated group (n = 6), acute stroke (AS) gr...
Source: Life Sciences - October 10, 2019 Category: Biology Source Type: research
Potential therapeutic and protective effect of curcumin against stroke in the male albino stroke-induced model rats
Publication date: Available online 27 June 2017 Source:Life Sciences Author(s): Yuanyuan Zhang, Yi Yan, Yi Cao, Yongtao Yang, Qing Zhao, Rui Jing, Jiayi Hu, Juan Bao Aims The present study was carried out to understand the therapeutic effect of curcumin (CUR) against stroke in the experimental animal model. The study investigates the healing effect of CUR on mitochondrial dysfunction and inflammation. Materials and methods Male albino, Wistar strain rats were used for the induction of middle cerebral artery occlusion (MCAO), and reperfusion. Enzyme-linked immunosorbent assay (ELISA) was used for the determination of inter...
Source: Life Sciences - June 27, 2017 Category: Biology Source Type: research
Electroacupunctre improves motor impairment via inhibition of microglia-mediated neuroinflammation in the sensorimotor cortex after ischemic stroke
Publication date: Available online 14 March 2016 Source:Life Sciences Author(s): Weilin Liu, Xian Wang, Shanli Yang, Jia Huang, Xiehua Xue, Yi Zheng, Guanhao Shang, Jing Tao, Lidian Chen Aims Electroacupuncture (EA) is one of the safety and effective therapies for improving neurological and sensorimotor impairment via blockade of inappropriate inflammatory responses. However, the mechanisms of anti-inflammation involved is far from been fully elucidated. Main methods Focal cerebral ischemic stroke was administered by the middle cerebral artery occlusion and reperfusion (MCAO/R) surgery. The MCAO/R rats were acc...
Source: Life Sciences - March 14, 2016 Category: Biology Source Type: research
