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NYU Dentistry awarded $1.9M NIH grant to study mitochondrial changes behind stroke, heart attack
(New York University) The National Institute of General Medical Sciences, part of the National Institutes of Health (NIH), has awarded NYU College of Dentistry's Evgeny Pavlov a grant to study a phenomenon called mitochondrial permeability transition, one of the central causes of tissue damage during stroke and heart attack.
Source: EurekAlert! - Biology - February 1, 2021 Category: Biology Source Type: news

Northwestern study tests drug against Parkinson's disease
(Northwestern University) Northwestern University Feinberg School of Medicine was awarded a grant from the National Institutes of Health to conduct a $16 million phase III national study of the safety and efficacy of the drug isradipine as a potential neuroprotective agent in Parkinson's disease. This is the only phase III Parkinson's neuroprotective study currently funded by the National Institute of Neurological Disorders and Stroke at NIH.
Source: EurekAlert! - Biology - April 1, 2014 Category: Biology Source Type: news

Rapid Identification of Novel Inhibitors of the Human Aquaporin‐1 Water Channel
This article is protected by copyright. All rights reserved. Aquaporin (AQP) channels play critical roles in several normal physiological and pathological states involving rapid water transport and are therefore drug targets. A high‐throughput cell‐based screening on > 6000 small molecular weight compounds identified several AQP1 blockers. Compared to canonical mercurial compounds, water transport assay in vesicles (Figure) identified two groups of most active novel AQP1 inhibitors e.g. a sulfonamide (compound 2), which constitute attractive leads for developing small‐molecule functional modulators for human AQP1.
Source: Chemical Biology and Drug Design - December 19, 2015 Category: Biology Authors: Rajkumar V. Patil, Shouxi Xu, Alfred N. van Hoek, Andrew Rusinko, Zixia Feng, Jesse May, Mark Hellberg, Najam A. Sharif, Martin B. Wax, Macarena Irigoyen, Grant Carr, Tom Brittain, Peter Brown, Damon Colbert, S. Kumari, K. Varadaraj, Alok K. Mitra Tags: Research Article Source Type: research

Scientists win $1.7 million grant to advance new strategies to treat Huntington's disease
(Scripps Research Institute) Scientists from the Florida campus of The Scripps Research Institute have won nearly $1.7 million from the National Institutes of Health's National Institute of Neurological Disorders and Stroke to investigate the mechanisms that contribute to Huntington's disease, a fatal inherited disease that some have described as having ALS, Parkinson's and Alzheimer's -- at the same time.
Source: EurekAlert! - Biology - February 12, 2016 Category: Biology Source Type: news

Kent State exercise science/physiology faculty gets grant to study probiotics and exercise
(Kent State University) Kent State University's Exercise Science/Physiology Program was awarded a $248,000 grant by i-Health Inc. to conduct a study relating to the use of probiotics and physical exercise. Kent State faculty and students are interested in combating heat-caused complications during exercise, such as heat stroke and heat exhaustion.
Source: EurekAlert! - Biology - November 15, 2017 Category: Biology Source Type: news

Aquinnah Pharmaceuticals receives $3.4 million grant from NINDS to advance new therapies for ALS
(MacDougall Biomedical Communications, Inc.) Aquinnah Pharmaceuticals, leaders in stress granule biology, an exciting new target for the development of neurodegenerative therapeutics, announced today that it has been awarded $3.4 million from the National Institute of Neurological Disorders and Stroke (NINDS) in a competing grant to advance novel therapeutic drug candidates towards the clinic for treating patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
Source: EurekAlert! - Biology - June 20, 2018 Category: Biology Source Type: news

UCI researcher awarded nearly $4 million to study neurological disorders including epilepsy
(University of California - Irvine) University of California, Irvine School of Medicine researcher Geoff Abbott, PhD, has been awarded a $2 million Outstanding Investigator Award/Maximizing Investigators' Research Award (MIRA) R35 grant from the National Institute of General Medical Sciences, and a $1.7 million R01 grant from the National Institute of Neurological Disorders and Stroke.
Source: EurekAlert! - Biology - February 27, 2019 Category: Biology Source Type: news

GW researcher seeks to improve diagnostic utility of neonatal EEGs
(George Washington University) A researcher at the GW School of Medicine and Health Sciences is working to improve diagnostic utility of neonatal EEGs thanks to grant awards from the National Eye Institute and the National Institute of Neurological Disorders and Stroke.
Source: EurekAlert! - Biology - May 15, 2019 Category: Biology Source Type: news

Short Takes
The National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) is soliciting public input on best practices and innovative ideas for education in the principles of rigorous research as well as promotion of rigorous research practices. Responses to this Request for Information (RFI) can be submitted online via this webform or via an email to RigorChampions@nih.gov by August 1, 2020. If submitting by email, please include the Notice number (NOT-NS-20-062) in the subject line. More information can be found at https://grants.nih.gov/grants/guide/notice-files/NOT-NS-20-062.html. ...
Source: Public Policy Reports - July 6, 2020 Category: Biology Authors: AIBS Source Type: news

Temple scientists take deep dive into molecular causes of abnormal clotting in CV disease
(Temple University Health System) Dr. Satya P. Kunapuli's research has given him extensive insight into the role of abnormal clot formation in cardiovascular disease. But the answer to one question has remained elusive: how do platelets become activated to form clots that ultimately lead to cardiovascular diseases like stroke and heart attack? Now, thanks to a new NIH grant, Dr. Kunapuli will be able to focus his research on this fundamental question.
Source: EurekAlert! - Biology - June 7, 2021 Category: Biology Source Type: news