UCI researcher awarded nearly $4 million to study neurological disorders including epilepsy

(University of California - Irvine) University of California, Irvine School of Medicine researcher Geoff Abbott, PhD, has been awarded a $2 million Outstanding Investigator Award/Maximizing Investigators' Research Award (MIRA) R35 grant from the National Institute of General Medical Sciences, and a $1.7 million R01 grant from the National Institute of Neurological Disorders and Stroke.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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It would dedicate $1.5 billion of its total to research and therapy for Alzheimer ’s Disease, Parkinson’s Disease, stroke, epilepsy and other brain and central nervous system conditions.
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Authors: Nieto-Estévez V, Hsieh J Abstract Epilepsy is a common neurological disorder characterized by recurrent and unprovoked seizures due to neuronal hyperactivity. A large proportion of epilepsy cases begin during childhood. Causes of epilepsy include stroke, infections, brain injury, genetic factors, or other factors that alter brain structure and development, but in up to 50% of cases the cause is unknown. Approximately 35% of patients have refractory seizures that do not respond to medication. Animal models and in vitro cultures have contributed to our understanding of epilepsy, but there is a clear n...
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
Cerebrovascular disease is a well-known cause of epilepsy. Multiple investigators have also reported that an onset of seizures after middle age can precede stroke [1 –8] and the term “heraldic seizures” has been suggested [9]. Several plausible explanations exist; late-onset epileptic seizures may reflect occult cerebrovascular disease, promote isolation and reduced physical activity, or result in treatment with antiepileptic drugs that, in turn, increase cardiovascular risk. Whether late-onset epilepsy should prompt cardiovascular workup and primary prevention of stroke remains uncertain, and there is cu...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
Telemedicine is the provision of health care services to a patient separated from the physician by a distance, with the help of information technologies and telecommunication[1]. In recent years, there is quick advancement of scope and usage of telemedicine in the field of neurology, also referred to as teleneurology. Beginning with acute stroke care, it is fast expanding to the care of persons with multiple sclerosis, Parkinson ’s disease, and epilepsy[2–6]. The two key factors driving the ever-increasing demand for telemedicine in Neurology are limited access to specialists (Neurologists) and difficulties fac...
Source: Seizure: European Journal of Epilepsy - Category: Neurology Authors: Source Type: research
Abstract ∆ 9 -Tetrahydrocannabinol (∆9 -THC), the active phytocannabinoid in cannabis, is virtually an adjunct to the endogenous endocannabinoid signaling system. By interacting with G-protein-coupled receptors CB1 and CB2, ∆9 -THC affects peripheral and central circulation by lowering sympathetic activity, altering gene expression, cell proliferation, and differentiation, decreasing leukocyte migration, modulating neurotransmitter release thereby modulating cardiovascular functioning, tumorigenesis, immune responses, behavioral and locomotory activities respectively. ∆ 9 -THC is effective in suppressing c...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research
Mitochondrial disorders may present from birth to adulthood and are characterized by dysfunction of the mitochondrial respiratory chain due to pathogenic variants in mitochondrial DNA (mtDNA) or nuclear DNA, with an estimated incidence of 1/5000 1. Mitochondrial disorders have a broad phenotypic spectrum and may fall into one of several classic phenotypic presentations (e.g., mitochondrial encephalopathy with lactic acidosis and stroke-like episodes: MELAS; Leber hereditary optic neuropathy: LHON; myoclonic epilepsy with ragged red fibers: MERRF, Kearns-Sayre syndrome: KSS, among others) or may present with variable sympto...
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Editorials Source Type: research
CONCLUSION: There are notable deficits in MFTD training for specialists in Ireland and the UK. Common conditions which can significantly impair MFTD such as stroke, diabetes and alcohol use disorders are severely underrepresented and curricula should be revisited to include relevant training and guidance on MFTD for trainees. PMID: 32936112 [PubMed - as supplied by publisher]
Source: Journal of the Royal College of Physicians of Edinburgh - Category: General Medicine Tags: J R Coll Physicians Edinb Source Type: research
Recent advances in artificial intelligence (AI) and deep learning (DL) hold promise to augment neuroimaging diagnosis for patients with brain tumors and stroke. Here, the authors review the diverse landscape of emerging neuroimaging applications of AI, including workflow optimization, lesion segmentation, and precision education. Given the many modalities used in diagnosing neurologic diseases, AI may be deployed to integrate across modalities (MR imaging, computed tomography, PET, electroencephalography, clinical and laboratory findings), facilitate crosstalk among specialists, and potentially improve diagnosis in patient...
Source: Neuroimaging Clinics - Category: Radiology Authors: Source Type: research
Electroencephalography (EEG) devices are incredibly helpful in diagnosing and monitoring certain brain disorders, such as epilepsy and strokes. However, they are not particularly user-friendly or convenient, with specialized technicians performing ti...
Source: Medgadget - Category: Medical Devices Authors: Tags: Exclusive Neurology Source Type: blogs
This report discusses some of the possible mechanisms for this patient's presentation. Although the mechanism of his musical hallucinations remains unclear, recognition of this uncommon syndrome is important when structuring rehabilitation and management for patients with stroke who have this disorder. PMID: 32930641 [PubMed - as supplied by publisher]
Source: Neurocase - Category: Neurology Authors: Tags: Neurocase Source Type: research
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