UCI researcher awarded nearly $4 million to study neurological disorders including epilepsy
(University of California - Irvine) University of California, Irvine School of Medicine researcher Geoff Abbott, PhD, has been awarded a $2 million Outstanding Investigator Award/Maximizing Investigators' Research Award (MIRA) R35 grant from the National Institute of General Medical Sciences, and a $1.7 million R01 grant from the National Institute of Neurological Disorders and Stroke.
Mitochondrial disorders may present from birth to adulthood and are characterized by dysfunction of the mitochondrial respiratory chain due to pathogenic variants in mitochondrial DNA (mtDNA) or nuclear DNA, with an estimated incidence of 1/5000 1. Mitochondrial disorders have a broad phenotypic spectrum and may fall into one of several classic phenotypic presentations (e.g., mitochondrial encephalopathy with lactic acidosis and stroke-like episodes: MELAS; Leber hereditary optic neuropathy: LHON; myoclonic epilepsy with ragged red fibers: MERRF, Kearns-Sayre syndrome: KSS, among others) or may present with variable sympto...
CONCLUSION: There are notable deficits in MFTD training for specialists in Ireland and the UK. Common conditions which can significantly impair MFTD such as stroke, diabetes and alcohol use disorders are severely underrepresented and curricula should be revisited to include relevant training and guidance on MFTD for trainees. PMID: 32936112 [PubMed - as supplied by publisher]
Recent advances in artificial intelligence (AI) and deep learning (DL) hold promise to augment neuroimaging diagnosis for patients with brain tumors and stroke. Here, the authors review the diverse landscape of emerging neuroimaging applications of AI, including workflow optimization, lesion segmentation, and precision education. Given the many modalities used in diagnosing neurologic diseases, AI may be deployed to integrate across modalities (MR imaging, computed tomography, PET, electroencephalography, clinical and laboratory findings), facilitate crosstalk among specialists, and potentially improve diagnosis in patient...
Electroencephalography (EEG) devices are incredibly helpful in diagnosing and monitoring certain brain disorders, such as epilepsy and strokes. However, they are not particularly user-friendly or convenient, with specialized technicians performing ti...
This report discusses some of the possible mechanisms for this patient's presentation. Although the mechanism of his musical hallucinations remains unclear, recognition of this uncommon syndrome is important when structuring rehabilitation and management for patients with stroke who have this disorder. PMID: 32930641 [PubMed - as supplied by publisher]
Assessment of recurrence risk is fundamental after a first epileptic seizure. In general, the risk of recurrence is approximately 21 –45 % in the next five years; brain disorders like trauma, infections and stroke increase the risk of recurrence, as do nocturnal seizures, imaging abnormalities, epileptiform activity on the electroencephalogram (EEG), or abnormal neurological examination [1,2]. Based on the risk assessment, pati ents may be counselled on safety or driving. In some circumstances, clinicians may also offer antiseizure medication (ASM) already after a first seizure.
Post-stroke epilepsy (PSE) is associated with poorer quality of life, higher mortality, and greater health expenditures. We are unaware of any published reports on the frequency of and factors associated with PSE in Africa.
CONCLUSION: The wide spectrum of secondary complications after a stroke constitutes a complex, sustained and multidisciplinary challenge, which requires a cross-sectoral interaction of various and numerous actors in outpatient poststroke care. PMID: 32914296 [PubMed - as supplied by publisher]
CONCLUSIONS: Data from the literature suggest an association between statin use and a reduced risk of ASPSS after ischemic stroke and a reduced risk of PSE after ischemic and hemorrhagic stroke. Although the certainty of the evidence is low, these findings appear promising and worthy of further investigation. PMID: 32916580 [PubMed - as supplied by publisher]
Conclusions: EMS diagnostic impressions have reasonable PPV and specificity but low sensitivity for GCSE. Improved coding algorithms and training will allow for improved benchmarking, quality improvement, and research about this neurologic emergency. PMID: 32870726 [PubMed - as supplied by publisher]