UCI researcher awarded nearly $4 million to study neurological disorders including epilepsy

(University of California - Irvine) University of California, Irvine School of Medicine researcher Geoff Abbott, PhD, has been awarded a $2 million Outstanding Investigator Award/Maximizing Investigators' Research Award (MIRA) R35 grant from the National Institute of General Medical Sciences, and a $1.7 million R01 grant from the National Institute of Neurological Disorders and Stroke.
Source: EurekAlert! - Biology - Category: Biology Source Type: news

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Publication date: Available online 14 March 2019Source: The Lancet NeurologyAuthor(s): Valery L Feigin, Emma Nichols, Tahiya Alam, Marlena S Bannick, Ettore Beghi, Natacha Blake, William J Culpepper, E Ray Dorsey, Alexis Elbaz, Richard G Ellenbogen, James L Fisher, Christina Fitzmaurice, Giorgia Giussani, Linda Glennie, Spencer L James, Catherine Owens Johnson, Nicholas J Kassebaum, Giancarlo Logroscino, Benoît Marin, W Cliff Mountjoy-VenningSummaryBackgroundNeurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases...
Source: The Lancet Neurology - Category: Neurology Source Type: research
Publication date: Available online 14 March 2019Source: Epilepsy &Behavior Case ReportsAuthor(s): Machlusil Husna, K. Shahdevi Nandar, Risma Karlina Prabawati, Siti NurlaelaAbstractStatus epilepticus (SE) is a serious health issue in developing countries, with high morbidity and mortality rates of 3%–46%. There are two types of SE, convulsive status epilepticus (CSE) and non-convulsive status epilepticus. The most common type, CSE, is easy to detect but, in several cases, the patients are diagnosed too late to be properly treated and hospitalized. The present study therefore investigated the clinical manifestatio...
Source: Epilepsy and Behavior Case Reports - Category: Neurology Source Type: research
Authors: Zhang H, Zheng L, Feng L Abstract Moyamoya disease (MMD) is a type of chronic cerebrovascular occlusion disease, which frequently occurs in East Asian populations, including pediatric and adult patients, and may lead to ischemic or hemorrhagic stroke, headache, epilepsy or transient ischemic attack. To date, the underlying mechanisms of MMD have remained to be fully elucidated, but certain studies have indicated that genetic factors may be an important component of its development. Cerebral angiography is the best approach for diagnosing MMD. However, with technological advances, non-invasive techniques ar...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
(NIH/National Institute of Neurological Disorders and Stroke) In a study of epilepsy patients, researchers at the National Institutes of Health found that split seconds before we recall past experiences tiny electrical waves, called ripples, may flow through key parts of our brains that help store our memories, setting the stage for successful retrieval.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Differential diagnosis between acute ischemic stroke (AIS) and epilepsy-related stroke mimics is sometimes difficult in the emergency department. We investigated whether a combination of diffusion-weighted imaging (DWI) and arterial spin labeling imaging (ASL) is useful in distinguishing AIS from epileptic disorders.
Source: Journal of Stroke and Cerebrovascular Diseases - Category: Neurology Authors: Source Type: research
mi JM Abstract BACKGROUND AND OBJECTIVES: Thrombotic microangiopathies constitute a diagnostic and therapeutic challenge. Secondary thrombotic microangiopathies are less characterized than primary thrombotic microangiopathies (thrombotic thrombocytopenic purpura and atypical hemolytic and uremic syndrome). The relative frequencies and outcomes of secondary and primary thrombotic microangiopathies are unknown. DESIGN, SETTING, PARTICIPANTS, &MEASUREMENTS: We conducted a retrospective study in a four-hospital institution in 564 consecutive patients with adjudicated thrombotic microangiopathies during the 20...
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
CONCLUSIONS AND RELEVANCE: Potentially modifiable risk factors in midlife and the APOE ε4 genotype were positively associated with risk of developing late-onset epilepsy. Although stroke and dementia were both associated with late-onset epilepsy, vascular and lifestyle risk factors were significant even in the absence of stroke or dementia. PMID: 30838917 [PubMed]
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
ConclusionThe dominance of hyperkinetic movements in the clinical scenario and the finding of a point mutation A3251G inMT-TL1 gene make this a rare presentation.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Purpose of review To summarize recent research findings and current concepts related to care of neurologic diseases in pregnancy and the risks of pregnancy to the mother–infant dyad. Recent publications related to best practices for neurologic care, risks of pregnancy, rate of relapse during and after pregnancy, as well as medication safety in pregnancy and lactation for more commonly used neurologic medications are reviewed. Recent findings Data continues to grow that women with neurologic conditions can experience pregnancy with minimal risks. Additionally, as more data is being published on medication safety ...
Source: Current Opinion in Obstetrics and Gynecology - Category: OBGYN Tags: MATERNAL FETAL MEDICINE: Edited by Deirdre Lyell, Mark Boddy, and Martha Rode Source Type: research
Epilepsy has been reported by the CDC to have a prevalence of 1.2% in the United States, which accounts for roughly 3.4 million adults in 2015. Nearly 1 million of those adults are aged 55 or older.1 Epilepsy is more likely to develop in older adults because risk factors for epilepsy are more common as people age including stroke/cardiovascular disease, neurodegenerative disorders, brain tumor and long-term sequelae of alcohol abuse.2 As our population ages, there will be even more older people with epilepsy.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Poster Number: EI - 9 Source Type: research
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