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Specialty: Hematology
Source: Haematologica

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Total 41 results found since Jan 2013.

Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population.
Abstract Risk factors for arterial ischaemic stroke in children include vasculopathy and prothrombotic risk factors but their relative importance to recurrent stroke is uncertain. Data on recurrent stroke from the databases held in Canada (Toronto), Germany (Kiel-Lubeck/Munster), and UK (London/Southampton) were pooled. Data were available from 894 patients aged 1 month to 18 years at first stroke (median age 6 years) with a median follow-up of 35 months. 160/894 patients (17.9%) had recurrence from 1 day to 136 months after first stroke (median 3.1 months). Among 288 children with vasculopathy, recurrence was sig...
Source: Haematologica - January 24, 2019 Category: Hematology Authors: deVeber G, Kirkham F, Shannon K, Brandão L, Sträter R, Kenet G, Clausnizer H, Moharir M, Kausch M, Askalan R, MacGregor D, Stoll M, Torge A, Dlamini N, Ganesan V, Prengler M, Singh J, Nowak-Göttl U Tags: Haematologica Source Type: research

Interleukin-1 receptor inhibition reduces stroke size in a murine model of sickle cell disease.
Abstract Sickle cell disease (SCD) is associated with chronic hemolytic anemia and a heightened inflammatory state. The causal role of inflammatory pathways in stroke associated with SCD is unclear. Therefore, the hypothesis that deletion of the non-hematopoietic interleukin-1 receptor (IL-1R) pool may be beneficial in SCD was pursued. Since potential deleterious effects of IL-1R signaling in SCD could be mediated via downstream production of interleukin-6 (IL-6), the role of the non-hematopoietic IL-6 pool was also addressed. Bone marrow transplantation (BMT) from SCD to wild-type (WT) recipient mice was used to ...
Source: Haematologica - August 12, 2020 Category: Hematology Authors: Venugopal J, Wang J, Mawri J, Guo C, Eitzman D Tags: Haematologica Source Type: research

Human stem cells transplanted into the rat stroke brain migrate to spleen via lymphatic and inflammation pathways.
This study is the first to demonstrate brain-to-periphery migration of stem cells, advancing the novel concept of harnessing the lymphatic system in mobilizing stem cells to sequester peripheral inflammation as a brain repair strategy. PMID: 30514806 [PubMed - as supplied by publisher]
Source: Haematologica - December 4, 2018 Category: Hematology Authors: Xu K, Lee JY, Kaneko Y, Tuazon JP, Vale F, van Loveren H, Borlongan CV Tags: Haematologica Source Type: research

The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice.
In conclusion, our data identify a potential role for VWF in the recruitment of proinflammatory monocytes, neutrophils and T-cells to the ischemic brain via a mechanism that is mediated by its A1 domain. PMID: 32107335 [PubMed - as supplied by publisher]
Source: Haematologica - February 26, 2020 Category: Hematology Authors: Denorme F, Martinod K, Vandenbulcke A, Denis CV, Lenting PJ, Deckmyn H, Vanhoorelbeke K, De Meyer SF Tags: Haematologica Source Type: research

Elevated lipoprotein (A), small APO (A), and the risk of arterial ischemic stroke in U.S. children.
CONCLUSIONS: Elevated Lp(a) and small apo(a) potently increase the risk of recurrent AIS in children, the mechanism for which is only partially attributable to impaired fibrinolysis. Collaborative studies are warranted to further investigate these findings, and more broadly to establish key risk factors for incident and recurrent arterial ischemic stroke in children. PMID: 23349301 [PubMed - as supplied by publisher]
Source: Haematologica - January 24, 2013 Category: Hematology Authors: Goldenberg NA, Bernard TJ, Hillhouse J, Armstrong-Wells J, Galinkin J, Knapp-Clevenger R, Jacobson L, Marcovina S, Manco-Johnson MJ Tags: Haematologica Source Type: research

Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance.
Abstract Ischemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment is focused on fast and efficient removal of the occluding thrombus, either via intravenous thrombolysis or via endovascular thrombectomy. Recanalization, however, is not always successful and factors contributing to failure are not completely understood. Although the occluding thrombus is the primary target of acute treatment, little is known about its internal organization and composition. The aim of this study, therefore, was to better understand the internal organization of ischemic stroke thrombi on a molecular and...
Source: Haematologica - May 1, 2019 Category: Hematology Authors: Staessens S, Denorme F, François O, Desender L, Dewaele T, Vanacker P, Deckmyn H, Vanhoorelbeke K, Andersson T, De Meyer SF Tags: Haematologica Source Type: research

Recurrent stroke: the role of thrombophilia in a large international pediatric stroke population.
PMID: 31575673 [PubMed - in process]
Source: Haematologica - September 30, 2019 Category: Hematology Authors: deVeber G, Kirkham F, Shannon K, Brandão L, Sträter R, Kenet G, Clausnizer H, Moharir M, Kausch M, Askalan R, MacGregor D, Stoll M, Torge A, Dlamini N, Ganesan V, Prengler M, Singh J, Nowak-Göttl U Tags: Haematologica Source Type: research

Predicting risk for recurrence of arterial ischemic stroke in children: thrombophilia as another piece of the puzzle.
PMID: 31366465 [PubMed - in process]
Source: Haematologica - July 31, 2019 Category: Hematology Authors: Aborkhees G, Mitchell LG Tags: Haematologica Source Type: research

Hydroxyurea to lower TCD velocities and prevent primary stroke: the Uganda NOHARM sickle cell anemia cohort.
Abstract *_. PMID: 31649130 [PubMed - as supplied by publisher]
Source: Haematologica - October 23, 2019 Category: Hematology Authors: Opoka RO, Hume HA, Latham TS, Lane A, Williams O, Tymon J, Nakafeero M, Kasirye P, Ndugwa CM, John CC, Ware RE Tags: Haematologica Source Type: research

Insights into the composition of stroke thrombi: heterogeneity and distinct clot areas impact treatment.
PMID: 32005654 [PubMed - in process]
Source: Haematologica - February 3, 2020 Category: Hematology Authors: Xu RG, Ariëns RAS Tags: Haematologica Source Type: research

Variation and impact of polygenic hematological traits in monogenic sickle cell disease
Haematologica. 2022 Oct 13. doi: 10.3324/haematol.2022.281180. Online ahead of print.ABSTRACTSeveral complications observed in sickle cell disease (SCD) are influenced by variation in hematological traits (HT), such as fetal hemoglobin (HbF) level and neutrophil count. Previous large-scale genome-wide association studies carried out in largely healthy individuals have identified 1000s of variants associated with HT, which have then been used to develop multiancestry polygenic trait scores (PTS). Here, we tested if these PTS associate with HT in SCD patients and can improve statistical models associated with SCD-related com...
Source: Haematologica - October 13, 2022 Category: Hematology Authors: Thomas Pincez Ken Sin Lo Anne-Laure Pham Hung d'Alexandry D'Orengiani Melanie E Garrett Carlo Brugnara Allison E Ashley-Koch Marilyn J Telen Frederic Galacteros Philippe Joly Pablo Bartolucci Guillaume Lettre Source Type: research