The von Willebrand Factor A1 domain mediates thromboinflammation, aggravating ischemic stroke outcome in mice.

In conclusion, our data identify a potential role for VWF in the recruitment of proinflammatory monocytes, neutrophils and T-cells to the ischemic brain via a mechanism that is mediated by its A1 domain.
PMID: 32107335 [PubMed - as supplied by publisher]

Source: Haematologica - February 26, 2020 Category: Hematology Authors: Denorme F, Martinod K, Vandenbulcke A, Denis CV, Lenting PJ, Deckmyn H, Vanhoorelbeke K, De Meyer SF Tags: Haematologica Source Type: research