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Specialty: Hematology
Condition: von Willebrand Disease
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Total 77 results found since Jan 2013.
Thrombus composition and thrombolysis resistance in stroke
Res Pract Thromb Haemost. 2023 May 16;7(4):100178. doi: 10.1016/j.rpth.2023.100178. eCollection 2023 May.ABSTRACTA State of the Art lecture titled "Thrombus Composition and Thrombolysis Resistance in Stroke" was presented at the ISTH Congress in 2022. Intravenous thrombolysis (IVT) remains the only pharmacologic option to re-establish cerebral perfusion at the acute phase of ischemic stroke. IVT is based on the administration of recombinant tissue plasminogen activator with the objective of dissolving fibrin, the major fibrillar protein component of thrombi. Almost 30 years on from its introduction, although the clinical b...
Source: Thrombosis and Haemostasis - August 4, 2023 Category: Hematology Authors: Benoit Ho-Tin-No é Jean-Philippe Desilles Mikael Mazighi Source Type: research
Coagulation biomarkers for ischemic stroke
We report on coagulation biomarker-induced risk of IS, stroke severity, and outcomes following IS derived from prospective population studies, case-control studies, and acute-phase IS studies. We found indications that many coagulation and inflammation biomarkers are associated with IS, but it is early to conclude that any of these biomarkers can be applied in a therapeutic setting to predict patients at risk of IS, stroke severity at the acute phase, and clinical outcome after treatment. The strongest evidence for a role in IS was found for beta-thromboglobulin, von Willebrand factor, factor VIII, fibrinogen, thrombin-act...
Source: Thrombosis and Haemostasis - June 5, 2023 Category: Hematology Authors: Aarazo Barakzie A J Gerard Jansen Hugo Ten Cate Moniek P M de Maat Source Type: research
von Willebrand factor, ADAMTS-13, and thrombospondin 1 in relation to clinical outcomes in elderly patients with a recent myocardial infarction
CONCLUSION: Although low ADAMTS-13 predicted death, the cardiovascular risk associated with VWF and ADAMTS-13 was weaker than previously reported. Low VWF is associated with new-onset AF and needs further research.PMID:37255854 | PMC:PMC10225923 | DOI:10.1016/j.rpth.2023.100164
Source: Thrombosis and Haemostasis - May 31, 2023 Category: Hematology Authors: Ellen M K Warlo Are A Kalstad Peder L Myhre Svein Solheim Harald Arnesen Arnljot Tveit P ål Andre Holme Ingebj ørg Seljeflot Vibeke Bratseth Source Type: research
Spatiotemporal profile of neutrophil extracellular trap formation in a mouse model of ischemic stroke
CONCLUSION: This study identified the spatiotemporal profile of NET formation in a mouse model of cerebral I/R injury in ischemic stroke. NETs, potentially in combination with VWF, might be attractive targets for the development of novel therapeutic strategies in ischemic stroke treatment.PMID:36852112 | PMC:PMC9958086 | DOI:10.1016/j.rpth.2022.100028
Source: Thrombosis and Haemostasis - February 28, 2023 Category: Hematology Authors: Maaike De Wilde Linda Desender Claudia Tersteeg Karen Vanhoorelbeke Simon F De Meyer Source Type: research
Hereditary thrombotic thrombocytopenic purpura and COVID-19: Impacts of vaccination and infection in this rare disease
DISCUSSION: The risk of an acute episode triggered by COVID-19 seems higher than following vaccination in hTTP patients, who can be safely vaccinated against SARS-CoV-2.PMID:36284639 | PMC:PMC9585384 | DOI:10.1002/rth2.12814
Source: Thrombosis and Haemostasis - October 26, 2022 Category: Hematology Authors: Erika Tarasco Anne Sophie von Krogh Radomira Hrdlickova Thomas R Braschler Teresa Iwaniec Paul N Kn öbl Eriko Hamada Oleg Pikovsky Stefan Farese Odit Gutwein Petr Kessler Nina H Schultz Charis von Auer Jerzy Windyga Kenneth Friedman Ingrid Hrachovinova J Source Type: research
Multi-phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
CONCLUSIONS: The discovery of 4 novel loci contributes to the understanding of the relationship between hemostasis and CV events and elucidate common genetic factors between these traits.PMID:35285134 | DOI:10.1111/jth.15698
Source: Thrombosis and Haemostasis - March 14, 2022 Category: Hematology Authors: Gerard Temprano-Sagrera Colleen M Sitlani William P Bone Miguel Martin-Bornez Benjamin F Voight Alanna C Morrison Scott M Damrauer Paul S de Vries Nicholas L Smith Maria Sabater-Lleal Source Type: research
Active FXI Can Independently Predict Ischemic Stroke in Anticoagulated Atrial Fibrillation Patients: A Cohort Study
CONCLUSION: FXIa present in circulating blood is associated with increased risk of ischemic stroke and cardiovascular death in anticoagulated AF patients during long-term follow-up. FXIa inhibition could be useful in cardiovascular prevention in AF beyond the current oral anticoagulation.PMID:35158400 | DOI:10.1055/s-0042-1742366
Source: Thrombosis and Haemostasis - February 14, 2022 Category: Hematology Authors: Micha ł Tomasz Ząbczyk Maksymilian Hanarz Krzysztof P Malinowski El żbieta Pociask Saulius Butenas Grzegorz Gajos Anetta Undas Source Type: research
Fibrin to von Willebrand factor ratio in arterial thrombi is associated with plasma levels of inflammatory biomarkers and local abundance of extracellular DNA
The composition of thrombi determines their structure, mechanical stability, susceptibility to lysis, and consequently, the clinical outcome in coronary artery disease (CAD), acute ischemic stroke (AIS), and peripheral artery disease (PAD). Fibrin forms the primary matrix of thrombi intertwined with DNA, derived from neutrophil extracellular traps (NETs), and von Willebrand factor (VWF) bridging DNA and platelets. Here we examined the relative content of fibrin, DNA and VWF in thrombi and analyzed their interrelations and quantitative associations with systemic biomarkers of inflammation and clinical characteristics of the patients.
Source: Thrombosis Research - November 17, 2021 Category: Hematology Authors: Erzs ébet Tóth, László Beinrohr, István Gubucz, László Szabó, Kiril Tenekedjiev, Natalia Nikolova, Anikó I. Nagy, László Hidi, Péter Sótonyi, István Szikora, Béla Merkely, Krasimir Kolev Source Type: research
