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Posterior Fossa Syndrome After Cerebellar Stroke.
We report longitudinal clinical, neurocognitive and neuroradiological findings in a 71-year-old right-handed patient who developed PFS following a right cerebellar haemorrhage that was not surgically evacuated. During follow-up, functional neuroimaging was conducted by means of quantified Tc-99m-ECD SPECT studies. After a 10-day period of akinetic mutism, the clinical picture developed into cerebellar cognitive affective syndrome (CCAS) with reversion to a previously learnt accent, consistent with neurogenic foreign accent syndrome (FAS). No psychometric evidence for dementia was found. Quantified Tc-99m-ECD SPECT studies ...
Source: Cerebellum - April 11, 2013 Category: Neuroscience Authors: Mariën P, Verslegers L, Moens M, Dua G, Herregods P, Verhoeven J Tags: Cerebellum Source Type: research

A Case of Transient Global Amnesia: A Review and How It May Shed Further Insight into the Neurobiology of Delusions
Conclusion In closing, our patient’s episode of TGA combined with her emotional and perceptual response lends credence to the proposal of a “fear/paranoia” circuit in the genesis of paranoid delusions—a circuit incorporating amygdala, frontal, and parietal cortices. Here, neutral or irrelevant stimuli, thoughts, and percepts come to engender fear and anxiety, while dysfunction in frontoparietal circuitry engenders inappropriate social predictions and maladaptive inferences about the intentions of others.[54] Hippocampus relays information about contextual information based on past experiences and the current situat...
Source: Innovations in Clinical Neuroscience - April 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Anxiety Disorders Behavioral and Cognitive Neurology Case Report Cognition Current Issue Dementia Medical Issues Neurologic Systems and Symptoms Psychiatry Schizophrenia delusions hippocampus neurobiology Transient global amnesia Source Type: research

Remote ischemic conditioning for the treatment of ischemic moyamoya disease.
CONCLUSIONS: Remote ischemic conditioning may be beneficial on controlling iMMD-induced ischemic events, relieving symptoms, and improving cerebral perfusion, without incidence of complications in this case series. PMID: 31814317 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - December 7, 2019 Category: Neuroscience Authors: Ding JY, Shang SL, Sun ZS, Asmaro K, Li WL, Yang Q, Ding YC, Ji XM, Meng R Tags: CNS Neurosci Ther Source Type: research

Cognitive and Affective Disturbances Following Focal Brainstem Lesions: A Review and Report of Three Cases.
Abstract Although insights in cerebellar neurocognition and affect are continuously growing, little is known about the role of the brainstem in cognitive and behavioural processing. In this paper, it is hypothesized that the brainstem is an inherent functional part of the cerebellocerebral network subserving cognition and affect, and that isolated brainstem damage may cause a constellation of symptoms closely resembling the cerebellar cognitive affective syndrome (CCAS) following cerebellar pathology. In order to investigate these premises, the available literature on cognitive and affective disturbances followin...
Source: Cerebellum - December 19, 2014 Category: Neuroscience Authors: D'aes T, Mariën P Tags: Cerebellum Source Type: research

The Posterior Fossa and Foreign Accent Syndrome: Report of Two New Cases and Review of the Literature.
Abstract Foreign accent syndrome is a rare motor speech disorder that causes patients to speak their language with a non-native accent. In the neurogenic condition, the disorder develops after lesions in the language dominant hemisphere, often affecting Broca's area, the insula, the supplementary motor area and the primary motor cortex. Here, we present two new cases of FAS after posterior fossa lesions. The first case is a 44-year-old, right-handed, Dutch-speaking man who suffered motor speech disturbances and a left hemiplegia after a pontine infarction. Quantified SPECT showed a bilateral hypoperfusion in the i...
Source: Cerebellum - March 23, 2017 Category: Neuroscience Authors: Keulen S, Mariën P, van Dun K, Bastiaanse R, Manto M, Verhoeven J Tags: Cerebellum Source Type: research

Brain imaging of locomotion in neurological conditions
Publication date: Available online 25 October 2018Source: Neurophysiologie CliniqueAuthor(s): Gilles Allali, Helena M. Blumen, Hervé Devanne, Elvira Pirondini, Arnaud Delval, Dimitri Van De VilleSummaryImpaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological diseases (mainly in Parkinson's disease) during actual walking, and while resting (using mental imagery of gait, or brain-behavior correlation analyses). These studies, using structural (i.e., MRI) or ...
Source: Neurophysiologie Clinique - October 26, 2018 Category: Neuroscience Source Type: research

Moyamoya disease with epileptic nystagmus: A case report
We report a case of moyamoya disease with epileptic nystagmus. A 23-year-old woman presented with a headache and transient hemiparesis on her left side. Magnetic resonance imaging showed no ischemic or hemorrhagic stroke lesions. Digital subtraction angiography confirmed stenosis of the terminal portion of the right internal carotid artery and the formation of moyamoya vessels on the right side. 123I-N-isopropyl-iodoamphetamine (123I-IMP) single photon emission computed tomography (SPECT) showed decreased uptake in the right basal ganglia, frontal, and parietal regions. After electroencephalography (EEG) and a hyperventila...
Source: Journal of Clinical Neuroscience - August 20, 2019 Category: Neuroscience Source Type: research

ASAP Micro-SPECT Imaging of Acute Ischemic Stroke with Radioiodinated Riboflavin in Rat MCAO Models via Riboflavin Transporter Targeting
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.2c00177
Source: ACS Chemical Neuroscience - June 26, 2022 Category: Neuroscience Authors: Jindian Li, Yingxi Chen, Chenyu Peng, Xingfang Hong, Huanhuan Liu, Jianyang Fang, Rongqiang Zhuang, Weimin Pan, Deliang Zhang, Zhide Guo, and Xianzhong Zhang Source Type: research