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Stroke Chameleons and Stroke Mimics in the Emergency Department
AbstractPurpose of ReviewWe discuss the frequency of stroke misdiagnosis in the emergency department (ED), identify common diagnostic pitfalls, describe strategies to reduce diagnostic error, and detail ongoing research.Recent FindingsThe National Academy of Medicine has re-defined and highlighted the importance of diagnostic errors for patient safety. Recent rates of stroke under-diagnosis (false-negative cases, “stroke chameleons”) range from 2–26% and 30–43% for stroke over-diagnosis (false-positive cases, “stroke mimics”). Failure to diagnosis stroke can preclude time-sensitive treatments and has been assoc...
Source: Current Neurology and Neuroscience Reports - February 21, 2017 Category: Neuroscience Source Type: research

Ketamine Therapy for Treatment-resistant Depression in a Patient with Multiple Sclerosis: A Case Report
Conclusion—Ketamine may be an alternative treatment for resistant depression and may have a special use in patients with multiple sclerosis. Introduction Depression is a frequent finding in patients with multiple sclerosis (MS), with the lifetime prevalence rates for major depressive disorder (MDD) ranging from 36 to 54 percent, more than twice of that in the general population.[1] Even with advances in pharmacological options for treating depression, an estimated 33 to 66 percent of patients with MDD in the general population do not respond to the first antidepressant, and a reported 15 to 33 percent of patients do not ...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Case Report Current Issue Depression Multiple Sclerosis Neurology Psychiatry Psychopharmacology Electroconvulsive therapy Ketamine major depressive disorder treatment-resistant depression Source Type: research

CNS Summit 2016 Abstracts of Poster Presentations
Conclusion: Subjects with acutely exacerbated schizophrenia who were eligible for discharge from the inpatient setting and who completed the study demonstrated high rates of adherence using the mobile AI application. Subjects were able to easily use the technology. Use of the platform did not appear to increase the dropout rate. This study demonstrates the feasibility of using AI platforms to ensure high adherence, provide reliable adherence data, and rapidly detect nonadherence in CNS trials. Disclosures/funding: Adam Hanina and Laura Shafner are employees of AiCure, New York, New York, and consultants to Takeda. Xinxin D...
Source: Innovations in Clinical Neuroscience - February 1, 2017 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools biomarkers Cognition Current Issue Devices Drug Development Evaluations Genetics Medical Issues Neurology Patient Assessment Proceedings Psychiatry Psychopharmacology Scales Supplements Technology Trial M Source Type: research

Pearce Bailey: The "Fifth Horseman" and the National Institute for Neurological Diseases and Blindness.
Authors: Burkholder DB Abstract Pearce Bailey (1902-1976) had an active career focused on the growth and development of neurology as a specialty in the post-World War II era. He was a founding member of the American Academy of Neurology (AAN) and its second president from 1951 to 1953. In 1951, he was also appointed as the first director of the National Institute for Neurological Diseases and Blindness (NINDB), which is now the National Institute of Neurological Disorders and Stroke. Known as an excellent politician, Bailey's role at the NINDB helped bolster the AAN in its early days. Prominent neurologists in the ...
Source: Journal of the History of the Neurosciences - August 19, 2018 Category: Neuroscience Tags: J Hist Neurosci Source Type: research

Abe Baker: Visionary and organizational leader of the American Academy of Neurology.
Authors: Lanska DJ Abstract American neurologist and neuropathologist Abraham Bert (Abe) Baker (1908-1988) was instrumental in founding the American Academy of Neurology and served as a catalyst for the emergence of neurology as a strong, independent medical discipline in the United States in the second half of the twentieth century. Baker served as the first president of the Academy from 1948 to 1951. He was also instrumental in garnering support for the National Institute of Neurological Diseases and Blindness, which was founded in 1950 and later evolved into the National Institute of Neurological Disorders and S...
Source: Journal of the History of the Neurosciences - August 19, 2018 Category: Neuroscience Tags: J Hist Neurosci Source Type: research