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Total 345 results found since Jan 2013.

Erectile dysfunction and obstructive sleep apnea: From mechanisms to a distinct phenotype and combined therapeutic strategies
Non-communicable diseases (NCDs), mainly cardiovascular diseases, cancer, diabetes, and chronic respiratory diseases, are responsible for two-thirds of the 57 million annual deaths worldwide. Tobacco smoking, physical inactivity, unhealthy diets and the resulting obesity are established risk factors for many chronic diseases (Fig. 1). Management of the rise in the prevalence of chronic diseases is a major challenge facing governments and health-care systems worldwide. As these disorders are now the leading causes of death and hospitalizations, health authorities assign high priority to heart disease, diabetes, sleep apnea...
Source: Sleep Medicine Reviews - December 27, 2014 Category: Sleep Medicine Authors: Jean-Louis Pépin, Renaud Tamisier, Diane Godin-Ribuot, Patrick A. Lévy Tags: Guest editorial Source Type: research

What can blood biomarkers tell us about cardiovascular risk in obstructive sleep apnea?
CONCLUSION: The results clearly demonstrate that the relationship between specific biomarkers and OSA is often influenced by age, gender or ethnicity, which has hindered the identification of a unique marker for the evaluation of all patients with OSA. Moreover, given the frequency of comorbidities in OSA, which, by themselves, increase the cardiovascular risk, all confounding factors must be considered in the evaluation of these biomarkers. PMID: 25716745 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - February 26, 2015 Category: Sleep Medicine Authors: de Araújo Freitas IG, de Bruin PF, Bittencourt L, de Bruin VM, Tufik S Tags: Sleep Breath Source Type: research

Sleep Duration and Mortality: A Prospective Study of 113,138 Middle-Aged and Elderly Chinese Men and Women
Conclusion:In our study population of Chinese adults, shorter and longer sleep durations were independently associated with increased risk of mortality. But longer sleep duration had a higher mortality risk of cardiovascular disease and diabetes than short sleep.Citation:Cai H, Shu XO, Xiang YB, Yang G, Li H, Ji BT, Gao J, Gao YT, Zheng W. Sleep duration and mortality: a prospective study of 113,138 middle-aged and elderly Chinese men and women. SLEEP 2015;38(4):529–536.
Source: Sleep - April 1, 2015 Category: Sleep Medicine Source Type: research

A Cost-Effectiveness Analysis of Surgery for Middle-Aged Men with Severe Obstructive Sleep Apnea Intolerant of CPAP
Conclusions:Palatopharyngeal reconstructive surgery appears cost-effective in middle-aged men with severe OSA intolerant of CPAP. Further research is warranted to better define surgical candidacy as well as short-term and long-term surgical outcomes.Commentary:A commentary on this article appears in this issue on page 509.Citation:Tan KB, Toh ST, Guilleminault C, Holty JE. A cost-effectiveness analysis of surgery for middle-aged men with severe obstructive sleep apnea intolerant of CPAP. J Clin Sleep Med 2015;11(5):525–535.
Source: Journal of Clinical Sleep Medicine : JCSM - May 14, 2015 Category: Sleep Medicine Source Type: research

Virchow-Robin Spaces: Correlations with Polysomnography-Derived Sleep Parameters
Conclusions:These preliminary results suggest that sleep may play a role in perivascular clearance in ischemic brain disease, and invite future research into the potential relevance of Virchow-Robin spaces as an imaging biomarker for nocturnal metabolite clearance.Citation:Berezuk C, Ramirez J, Gao F, Scott CJ, Huroy M, Swartz RH, Murray BJ, Black SE, Boulos MI. Virchow-Robin spaces: correlations with polysomnography-derived sleep parameters. SLEEP 2015;38(6):853–858.
Source: Sleep - May 30, 2015 Category: Sleep Medicine Source Type: research

Risk of Cardiovascular Disease Associated with a Restless Legs Syndrome Diagnosis in a Retrospective Cohort Study from Kaiser Permanente Northern California
Conclusion:Primary restless legs syndrome (RLS) was not associated with new-onset cardiovascular disease (CVD) or coronary artery disease (CAD) but was associated with a slight increased risk of hypertension. In contrast, secondary RLS was associated with an increased risk of CVD, CAD, and hypertension.Citation:Van Den Eeden SK, Albers KB, Davidson JE, Kushida CA, Leimpeter AD, Nelson LM, Popat R, Tanner CM, Bibeau K, Quesenberry CP. Risk of cardiovascular disease associated with a restless legs syndrome diagnosis in a retrospective cohort study from Kaiser Permanente Northern California. SLEEP 2015;38(7):1009–1015.
Source: Sleep - June 30, 2015 Category: Sleep Medicine Source Type: research

The Sleep Apnea cardioVascular Endpoints (SAVE) Trial: Rationale, Ethics, Design, and Progress
This article describes the rationale for the SAVE study, considerations given to the design including how various cultural and ethical challenges were addressed, and progress in establishing and maintaining the recruitment network, patient follow-up, and adherence to CPAP and procedures. The assumptions underlying the original trial sample size calculation and why this was revised downward in 2012 are also discussed.Clinical Trials Registration Number:NCT00738179.Australia New Zealand Clinical Trials Registry Number:ACTRN12608000409370.Citation:Antic NA, Heeley E, Anderson CS, Luo Y, Wang J, Neal B, Grunstein R, Barbe F, L...
Source: Sleep - August 1, 2015 Category: Sleep Medicine Source Type: research

Self-reported obstructive sleep apnea, simple snoring, and various markers of sleep-disordered breathing as predictors of cardiovascular risk.
CONCLUSIONS: Self-reported OSA and SDB-related snoring variables are associated with cardiovascular risk, whereas simple snoring is not. In clinical practice and in surveys, questions concerning only habitual snoring should be amended with questions focusing on respiratory pauses and snoring stertorousness, which can be used to estimate the risk of OSA and cardiovascular events. PMID: 26363577 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - September 12, 2015 Category: Sleep Medicine Authors: Niiranen TJ, Kronholm E, Rissanen H, Partinen M, Jula AM Tags: Sleep Breath Source Type: research

Phenotypes of comorbidity in OSAS patients: combining categorical principal component analysis with cluster analysis.
Abstract Phenotyping obstructive sleep apnea syndrome's comorbidity has been attempted for the first time only recently. The aim of our study was to determine phenotypes of comorbidity in obstructive sleep apnea syndrome patients employing a data-driven approach. Data from 1472 consecutive patient records were recovered from our hospital's database. Categorical principal component analysis and two-step clustering were employed to detect distinct clusters in the data. Univariate comparisons between clusters included one-way analysis of variance with Bonferroni correction and chi-square tests. Predictors of pairwise...
Source: Journal of Sleep Research - September 14, 2015 Category: Sleep Medicine Authors: Vavougios GD, Natsios G, Pastaka C, Zarogiannis SG, Gourgoulianis KI Tags: J Sleep Res Source Type: research

Obstructive Sleep Apnea as a Candidate Unifier in Atrial Fibrillation and Cryptogenic Stroke
Source: Sleep - October 31, 2015 Category: Sleep Medicine Source Type: research

More Wake, Less Stroke
Source: Sleep - October 31, 2015 Category: Sleep Medicine Source Type: research

The Determining Risk of Vascular Events by Apnea Monitoring (DREAM) study: design, rationale, and methods.
CONCLUSIONS: This manuscript provides the rationale for the inclusion of veterans in a study to determine the association between physiologic sleep measures and cardiovascular outcomes and specifically the development of a corresponding outcome-based prognostic model. PMID: 26642771 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - December 7, 2015 Category: Sleep Medicine Authors: Koo BB, Won C, Selim BJ, Qin L, Jeon S, Redeker NS, Bravata DM, Strohl KP, Concato J, Yaggi HK Tags: Sleep Breath Source Type: research

Lack of Association between Genetic Risk Loci for Restless Legs Syndrome and Multimorbidity
Conclusions:Based on these results it is unlikely that known genetic risk factors for RLS would lead to increased multimorbidity.Citation:Szentkirályi A, Völzke H, Hoffmann W, Winkelmann J, Berger K. Lack of association between genetic risk loci for restless legs syndrome and multimorbidity. SLEEP 2016;39(1):111–115.
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research

Regional Neocortical Gray Matter Structure and Sleep Fragmentation in Older Adults
Conclusions:Lower cortical gray matter volume in the lateral orbitofrontal cortex and inferior frontal gyrus pars orbitalis is associated with greater sleep fragmentation in older community-dwelling adults. Further work is needed to clarify whether this is a consequence of or contributor to sleep fragmentation.Commentary:A commentary on this article appears in this issue on page 15.Citation:Lim AS, Fleischman DA, Dawe RJ, Yu L, Arfanakis K, Buchman AS, Bennett DA. Regional neocortical gray matter structure and sleep fragmentation in older adults. SLEEP 2016;39(1):227–235.
Source: Sleep - January 12, 2016 Category: Sleep Medicine Source Type: research

Maternal dietary supplementation with omega-3 polyunsaturated fatty acids confers neuroprotection to the newborn against hypoxia-induced dopamine dysfunction
Conclusions Our findings suggest that it may be feasible to confer neuroprotection against hypoxia-induced dopamine dysfunction to newborns likely to experience hypoxic insults. This could significantly improve the outcomes of those 8–11% of newborns who would otherwise experience hypoxia-induced behavioral, motor and cognitive dysfunction.
Source: Sleep Science - June 8, 2016 Category: Sleep Medicine Source Type: research