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Secondary attention-deficit/hyperactivity disorder following perinatal and childhood stroke: impact on cognitive and academic outcomes.
Abstract This cross-sectional retrospective clinical research study examines a large group of children followed within a pediatric stroke program and a developmental attention-deficit/hyperactivity disorder (ADHD) clinic at the Hospital for Sick Children, between May 2004 and June 2016. All children with a history of stroke who participated in a neuropsychological assessment between the ages of 4 and 18 years were considered for inclusion. From a sample of 275 participants with a history of stroke, 36 children (13.1%) received a diagnosis of secondary ADHD. Children with secondary ADHD were younger at the time of...
Source: Child Neuropsychology - May 30, 2017 Category: Child Development Authors: Williams TS, Roberts SD, Coppens AM, Crosbie J, Dlamini N, Westmacott R Tags: Child Neuropsychol Source Type: research

Academic outcome in pediatric ischemic stroke.
Abstract An important cause of acquired brain injury in children, pediatric ischemic stroke can cause sequelae across a wide range of cognitive domains, including verbal reasoning and processing speed. As a result, survivors are especially vulnerable to academic difficulties and face unique challenges compared to their peers. Despite this knowledge, pediatric stroke remains an understudied neurological condition, and its impact on school functioning poorly understood. The present clinical study addressed academic outcome in this population using a multifaceted approach. Patients were recruited for participation fr...
Source: Child Neuropsychology - January 8, 2020 Category: Child Development Authors: Champigny CM, Deotto A, Westmacott R, Dlamini N, Desrocher M Tags: Child Neuropsychol Source Type: research

Association between radiographic Wallerian degeneration and neuropathological changes post childhood stroke
Aim  Wallerian degeneration is a radiological finding thought to reflect corticospinal tract degeneration. This finding on magnetic resonance imaging (MRI) is routinely used as a predictor of poor prognosis in childhood stroke. However, its validity has never been established. Our objective was to correlate Wallerian degeneration seen on MRI with histopathology. Method  We searched the databases of the Department of Pathology and Children’s Stroke registry at the Hospital for Sick Children, Toronto for autopsy specimens exhibiting focal infarcts from children born at term who underwent MRI after a stroke. The specime...
Source: Developmental Medicine and Child Neurology - November 22, 2012 Category: Child Development Authors: KEVIN C JONES, CYNTHIA HAWKINS, DEREK ARMSTRONG, GABRIELLE DEVEBER, DAUNE MACGREGOR, MAHENDRANATH MOHARIR, RAND ASKALAN Tags: ORIGINAL ARTICLE Source Type: research

Are children with acute arterial ischaemic stroke eligible for hyperacute thrombolysis? A retrospective audit from a tertiary UK centre
AimThe aim of this study was to evaluate the number of children with acute arterial ischaemic stroke (AIS) who would have been eligible for hyperacute thrombolysis in the authors' unit (Great Ormond Street Hospital, London, UK) and to identify barriers to this treatment. MethodWe compared the characteristics of children with a diagnosis of acute AIS, identified from neuroimaging databases, seen at our centre between January 2006 and December 2011. The criteria for hyperacute thrombolysis were predefined by us: age ≥8y; imaging‐confirmed diagnosis of acute AIS and arrival at our centre within 6 hours of symptom onset; ...
Source: Developmental Medicine and Child Neurology - September 18, 2014 Category: Child Development Authors: Clara Marecos, Roxana Gunny, Robert Robinson, Vijeya Ganesan Tags: Original Article Source Type: research

The epidemiology of intermittent and chronic ataxia in children in Manitoba, Canada
AimTo determine the epidemiology of chronic ataxia in children in Manitoba, Canada. MethodA retrospective study using multiple sources and disease codes identified children (age 0–16y) with chronic ataxia (>2mo duration or recurrent episodes of ataxia) seen at Winnipeg Children's Hospital from 1991 to 2008. Patients with isolated peripheral nerve diseases, vestibular disorders, or brain tumors were excluded. ResultsWe identified 184 patients (males=females; mean age 15y, SD 7y 8mo) with chronic ataxia. Median age at the presenting symptom onset was 1 year 3 months and at ataxia onset 3 years 1 month. Median durati...
Source: Developmental Medicine and Child Neurology - February 7, 2013 Category: Child Development Authors: Michael S Salman, Esther J Lee, Anindita Tjahjadi, Bernard N Chodirker Tags: Original Article Source Type: research

Performance on the Test of Memory Malingering in children with neurological conditions.
Abstract Despite increasing interest in the use of performance validity tests with youth, relatively little is known about how children and adolescents with neurological diagnoses perform on these measures. The purpose of this study was to examine performance on the Test of Memory Malingering (TOMM) in a general pediatric neurologic sample. Data were obtained from 266 consecutive patients (mean age = 13.0, SD = 3.7, range = 5-18) referred for a neuropsychological assessment in a tertiary care pediatric hospital. As part of a broader neuropsychological battery, patients were administered the TOMM. In this sam...
Source: Child Neuropsychology - December 11, 2014 Category: Child Development Authors: Ploetz DM, Mazur-Mosiewicz A, Kirkwood MW, Sherman EM, Brooks BL Tags: Child Neuropsychol Source Type: research