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Treatment Patterns and Short-Term Outcomes in Ischemic Stroke in Pregnancy or Postpartum
Stroke is a rare but devastating event during pregnancy, occurring in 34/100,000 deliveries, and obstetricians are often the first providers to be contacted by symptomatic patients. At least half of pregnancy-related strokes are likely to be of the ischemic stroke subtype. Most pregnant or newly postpartum women with ischemic stroke do not receive acute stroke reperfusion therapy although this is the recommended treatment for adults. Little is known about these therapies in pregnant or postpartum women as pregnancy has been an exclusion criteria for all reperfusion trials.
Source: American Journal of Obstetrics and Gynecology - December 17, 2015 Category: OBGYN Authors: Lisa R. Leffert, Caitlin R. Clancy, Brian T. Bateman, Margueritte Cox, Phillip J. Schulte, Eric E. Smith, Gregg C. Fonarow, Elena V. Kuklina, Mary G. George, Lee H. Schwamm Source Type: research

Treatment patterns and short-term outcomes in ischemic stroke in pregnancy or postpartum period
Stroke, which is a rare but devastating event during pregnancy, occurs in 34 of every 100,000 deliveries; obstetricians are often the first providers to be contacted by symptomatic patients. At least one-half of pregnancy-related strokes are likely to be of the ischemic stroke subtype. Most pregnant or newly postpartum women with ischemic stroke do not receive acute stroke reperfusion therapy, although this is the recommended treatment for adults. Little is known about these therapies in pregnant or postpartum women because pregnancy has been an exclusion criterion for all reperfusion trials.
Source: American Journal of Obstetrics and Gynecology - December 17, 2015 Category: OBGYN Authors: Lisa R. Leffert, Caitlin R. Clancy, Brian T. Bateman, Margueritte Cox, Phillip J. Schulte, Eric E. Smith, Gregg C. Fonarow, Elena V. Kuklina, Mary G. George, Lee H. Schwamm Tags: Original Research Source Type: research

Hypertensive disorders of pregnancy and long-term risk of maternal stroke —a systematic review and meta-analysis
Hypertensive disorders of pregnancy are associated with a long-term risk for cardiovascular disease among parous patients later in life. However, relatively little is known about whether hypertensive disorders of pregnancy are associated with an increased risk for ischemic stroke or hemorrhagic stroke in later life. This systematic review aimed to synthesize the available literature on the association between hypertensive disorders of pregnancy and the long-term risk for maternal stroke.
Source: American Journal of Obstetrics and Gynecology - March 27, 2023 Category: OBGYN Authors: Matthew P. Brohan, Fionn P. Daly, Louise Kelly, Fergus P. McCarthy, Ali S. Khashan, Karolina Kublickiene, Peter M. Barrett Tags: Systematic Review Source Type: research

841: Stroke in pregnancy
In the US, stroke associated with pregnancy occurs in about 35 per 100,000 births. Prior studies have focused on national registries or medico-legal case series. Our objectives were to 1) describe type, antecedent events, and outcomes with strokes and 2) compare women with hypertensive disorders versus those without, as well as those with stroke in antepartum versus postpartum periods.
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Corey Clifford, Nana-Ama Ankumah, Andrew Valenzuela, Agnes Ditishiem, Baha Sibai Tags: Poster Session IV Source Type: research

462: The effects of maternal position and habitus on left ventricular stroke volume during pregnancy measured by cardiac magnetic resonance
To evaluate left ventricular stroke volume (LVSV) changes according to maternal position and habitus throughout normal pregnancy using serial cardiac magnetic resonance imaging (CMRI).
Source: American Journal of Obstetrics and Gynecology - December 19, 2014 Category: OBGYN Authors: David Nelson, Robert Stewart, Susan Matulevicius, Donald McIntire, Mark Drazner, F. Gary Cunningham Tags: Poster session III Source Type: research

Temporal trends in pregnancy associated stroke: risk factors and associated outcomes, a  national cohort
Our aim was to assess the temporal trend and to ascertain whether risks factors or adverse outcomes in the U.S. differed by timing of pregnancy associated stroke (antepartum versus postpartum).
Source: American Journal of Obstetrics and Gynecology - January 1, 2023 Category: OBGYN Authors: Ghamar Bitar, Han-Yang Chen, Sami Backley, Suneet P. Chauhan, Baha M. Sibai, Michal Fishel Bartal Tags: Poster Session II Source Type: research

Pregnancy associated stroke and hypertension: a national cohort evaluating temporal trends, risk factors, and mortality
Our aim was to evaluate the association between pregnancy associated stroke (PAS) and hypertensive disorder in the U.S.
Source: American Journal of Obstetrics and Gynecology - January 1, 2023 Category: OBGYN Authors: Ghamar Bitar, Baha M. Sibai, Han-Yang Chen, Sami Backley, Suneet P. Chauhan, Michal Fishel Bartal Tags: Poster Session II Source Type: research

Differential expression of plasma microRNA in preeclamptic patients at delivery and 1 year postpartum
Pre-eclampsia (PE) is a hypertensive disorder of pregnancy characterized by widespread maternal endothelial dysfunction. Although clinical signs subside following delivery, long-term risks associated with PE include hypertension, stroke and cardiovascular disease. miRNAs are emerging as critical regulators of biological function, and while alterations to the miRNAome have been described in the context of pregnancy and PE, the postpartum implications of PE on miRNA expression is unknown. The goal of this study was to characterize circulating miRNA profiles at the time of delivery and at one year postpartum for women who did...
Source: American Journal of Obstetrics and Gynecology - May 13, 2015 Category: OBGYN Authors: Malia S.Q. Murphy, Richard C. Casselman, Chandrakant Tayade, Graeme N. Smith Source Type: research

Duration of pregnancy, even at term, predicts long-term risk of coronary heart disease and stroke mortality in women: a population-based study
Preterm delivery may predict increased risk of cardiovascular disease in mothers, providing opportunities for prevention. No study had examined whether gestation length within the term period predicts future CVD, and there are few data segregating spontaneous from medically indicated deliveries.
Source: American Journal of Obstetrics and Gynecology - June 9, 2015 Category: OBGYN Authors: Janet W. Rich-edwards, Kari Klungsoyr, Allen J. Wilcox, Rolv Skjaerven Source Type: research

Pregnancy in advanced age and the risk of stroke in post-menopausal women. Analysis of Women's Health Initiative Study
The incidence of pregnancy in advanced age among women is increasing due to availability of assisted reproduction although the long-term health consequences are not known.
Source: American Journal of Obstetrics and Gynecology - December 8, 2016 Category: OBGYN Authors: Adnan I. Qureshi, Omar Saeed, Ahmed A. Malik, M. Fareed K. Suri Tags: Original Research: Obstetrics Source Type: research

Pregnancy in advanced age and the risk of stroke in postmenopausal women: analysis of Women ’s Health Initiative Study
The incidence of pregnancy in advanced age among women is increasing because of the availability of assisted reproduction, although the long-term health consequences are not known.
Source: American Journal of Obstetrics and Gynecology - December 8, 2016 Category: OBGYN Authors: Adnan I. Qureshi, Omar Saeed, Ahmed A. Malik, M. Fareed K. Suri Tags: Original Research Source Type: research

Effect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life
Women with hypertensive disorders in pregnancy, in particular early-onset preeclampsia, are at increased risk of developing cardiovascular disease later in life. These women have a more than two-fold increased risk to die from cardiovascular diseases. Most studies focused on identification of risk factors shortly after pregnancy. Less is known on the prevalence of risk factors or actual signs of cardiovascular disease 5 – 20 years later. The presence of hypertension or metabolic syndrome can be seen as an opportunity for preventive interventions to reduce the development of severe cardiovascular diseases like myocardial ...
Source: American Journal of Obstetrics and Gynecology - February 12, 2017 Category: OBGYN Authors: Anouk Bokslag, Pim W. Teunissen, Constantijn Franssen, Floortje van Kesteren, Otto Kamp, Wessel Ganzevoort, Walter J. Paulus, Christianne J.M. de Groot Tags: Original Research: Obstetrics Source Type: research

799: 33-Year single center experience with pregnancy-associated strokes
To evaluate the incidence, presentation, and causes of pregnancy-related strokes at our single-center institution in relation to timing, characterization of stroke, risk factors, pregnancy outcomes, and residual neurologic deficits in order to identify at risk patients and to improve outcomes.
Source: American Journal of Obstetrics and Gynecology - January 1, 2018 Category: OBGYN Authors: Amanda Zofkie, F. Gary Cunningham Tags: Poster Session IV Source Type: research

96: Hyperoxygenation therapy in the third trimester leads to hemodynamic changes in maternal circulation
The impact of hyperoxygenation (HO) on maternal hemodynamics is currently unknown. We sought to examine the effect of brief hyperoxygenation on cardiac index (CI), systemic vascular resistance (SVR), blood pressure (BP), stroke volume (SV) and heart rate (HR) in pregnant mothers during the third trimester using transthoracic bioreactance (TRB).
Source: American Journal of Obstetrics and Gynecology - January 1, 2018 Category: OBGYN Authors: Ann McHugh, Liam Dwyer, Colm Breathnach, Elizabeth Tully, Orla Franklin, Afif El-Khuffash, Fionnuala Breathnach Tags: Oral Concurrent 8 Source Type: research

508: Readmission following discharge on labetalol or nifedipine for management of hypertensive disorders of pregnancy
Hypertensive disorders of pregnancy (HDP) confer significant maternal risks postpartum including risks of seizure, stroke and higher rates of postpartum readmission. Following delivery, women with blood pressure elevations are treated primarily with labetalol or nifedipine but it is unknown if one agent is more effective for blood pressure control following hospital discharge. We sought to compare rates of postpartum readmission and adverse maternal outcomes based on discharge on labetalol versus nifedipine.
Source: American Journal of Obstetrics and Gynecology - December 25, 2018 Category: OBGYN Authors: Samantha C. Do, Danielle M. Panelli, Anna I. Girsen, Sanaa Suharwardy, Jaclyn Estes, Ronald S. Gibbs, Yasser El- Sayed, Deirdre J. Lyell, Maurice L. Druzin, Jason Bentley Tags: Poster Session III Source Type: research

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