Filtered By:
Management: National Institutes of Health (NIH)
This page shows you your search results in order of relevance. This is page number 2.
Order by Relevance | Date
Total 1650 results found since Jan 2013.
RECAST (Remote Ischemic Conditioning After Stroke Trial) Brief Report
Background and Purpose—Repeated episodes of limb ischemia and reperfusion (remote ischemic conditioning [RIC]) may improve outcome after acute stroke.Methods—We performed a pilot blinded placebo-controlled trial in patients with acute ischemic stroke, randomized 1:1 to receive 4 cycles of RIC within 24 hours of ictus. The primary outcome was tolerability and feasibility. Secondary outcomes included safety, clinical efficacy (day 90), putative biomarkers (pre- and post-intervention, day 4), and exploratory hemodynamic measures.Results—Twenty-six patients (13 RIC and 13 sham) were recruited 15.8 hours (SD 6.2) post-ons...
Source: Stroke - April 24, 2017 Category: Neurology Authors: Timothy J. England, Amanda Hedstrom, Saoirse O’Sullivan, Richard Donnelly, David A. Barrett, Sarir Sarmad, Nikola Sprigg, Philip M. Bath Tags: Cerebrovascular Disease/Stroke Brief Reports Source Type: research
Circulating FABP4 (Fatty Acid-Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke Clinical Sciences
This study aimed at observing the effect of FABP4 on the 3-month outcomes in Chinese patients with acute ischemic stroke.Methods—In a prospective multicenter observational study, serum concentrations of FABP4 were on admission measured in plasma of 737 consecutive patients with acute ischemic stroke. Serum concentrations of FABP4, National Institutes of Health Stroke Scale score, and conventional risk factors were evaluated to determine their value to predict functional outcome and mortality within 3 months.Results—During follow-up, an unfavorable functional outcome was found in 260 patients (35.3%), and 94 patients (1...
Source: Stroke - May 22, 2017 Category: Neurology Authors: Wen-Jun Tu, Xian-Wei Zeng, Aijun Deng, Sheng-Jie Zhao, Ding-Zhen Luo, Guo-Zhao Ma, Hong Wang, Qiang Liu Tags: Biomarkers, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research
Posttreatment National Institutes of Health Stroke Scale Is Superior to the Initial Score or Thrombolysis in Cerebral Ischemia for 3-Month Outcome Clinical Sciences
Background and Purpose—The majority of ischemic stroke patients receiving endovascular recanalization therapy (EVT) experience variable changes of neurological severities during the hyperacute period. We hypothesized that the National Institutes of Health Stroke Scale (NIHSS) score after EVT is a better prognostic factor compared with the initial NIHSS score or revascularization status.Methods—We identified 566 stroke patients who received EVT at Seoul National University Bundang Hospital between April 2008 and December 2015. We prospectively collected post-EVT NIHSS score, which was measured in the angiography suite b...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Han-Gil Jeong, Beom Joon Kim, Jay Chol Choi, Keun-Sik Hong, Mi Hwa Yang, Cheolkyu Jung, Moon-Ku Han, Hee-Joon Bae Tags: Ischemic Stroke Original Contributions Source Type: research
Association of Blood Pressure With Short- and Long-Term Functional Outcome After Stroke Thrombectomy Clinical Sciences
This study aims to assess the association of BP changes during general anesthesia versus conscious sedation with functional outcome after mechanical thrombectomy.Methods—SIESTA (Sedation vs Intubation for Endovascular Stroke Treatment) was a monocentric randomized trial of general anesthesia versus conscious sedation during mechanical thrombectomy involving BP target protocols. In this post hoc analysis, BP measurements were divided into 4 phases: preintervention, prerecanalization, postrecanalization, and postintervention. We examined the association between BP and functional outcomes (defined by improvement of 24-hour ...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Silvia Schonenberger, Lorenz Uhlmann, Matthias Ungerer, Johannes Pfaff, Simon Nagel, Christina Klose, Martin Bendszus, Wolfgang Wick, Peter A. Ringleb, Meinhard Kieser, Markus A. Mohlenbruch, Julian Bosel Tags: Ischemic Stroke Original Contributions Source Type: research
Use of a 3-Item Short-Form Version of the Barthel Index for Use in Stroke Clinical Sciences
We describe concurrent validity (agreement of each SF-BI with BI), convergent and divergent validity (agreement of each SF-BI with other outcome measures available in the data set), predictive validity (association of prognostic factors with SF-BI outcomes), and content validity (item correlation and exploratory factor analyses).Results—From 3546 titles, we found 8 articles describing 6 differing SF-BI. Using acute trial data (n=8852), internal reliability suggested redundancy in BI (Cronbach α, 0.96). Each SF-BI demonstrated a strong correlation with BI, modified Rankin Scale, National Institutes of Health Stroke Scale (all ρ≥0.83; P
Source: Stroke - February 26, 2017 Category: Neurology Authors: Rachael L. MacIsaac, Myzoon Ali, Martin Taylor-Rowan, Helen Rodgers, Kennedy R. Lees, Terence J. Quinn Tags: Quality and Outcomes, Cerebrovascular Disease/Stroke Original Contributions Source Type: research
Stroke Outcomes Measures Must Be Appropriately Risk Adjusted to Ensure Quality Care of Patients: A Presidential Advisory From the American Heart Association/American Stroke Association AHA/ASA Presidential Advisory
This article details (1) why the Centers for Medicare & Medicaid Services acute ischemic stroke outcome measures in their present form may not provide adequate risk adjustment, (2) why the measures as currently designed may lead to inaccurate representation of hospital performance and have the potential for serious unintended consequences, (3) what activities the American Heart Association/American Stroke Association has engaged in to highlight these concerns to the Centers for Medicare & Medicaid Services and other interested parties, and (4) alternative approaches and opportunities that should be considered for m...
Source: Stroke - April 28, 2014 Category: Neurology Authors: Fonarow, G. C., Alberts, M. J., Broderick, J. P., Jauch, E. C., Kleindorfer, D. O., Saver, J. L., Solis, P., Suter, R., Schwamm, L. H. Tags: AHA Statements and Guidelines AHA/ASA Presidential Advisory Source Type: research
Clinical diagnostic tools for screening of perioperative stroke in general surgery: a systematic review
Perioperative stroke is a devastating complication that carries high mortality and functional disability. Unfortunately, residual anaesthesia and analgesia may obscure important warning signs and may lead to a delay in the assessment and treatment of major stroke after surgery. The purpose of this review is to examine the utility of existing stroke scales, for the recognition of perioperative stroke in the general surgical population. A total of 21 stroke scales have been described in the literature. Diagnostic performance was reported in 17 scales. The majority of the stroke scales were designed to evaluate current neurol...
Source: British Journal of Anaesthesia - February 10, 2016 Category: Anesthesiology Authors: Sun, Z., Yue, Y., Leung, C. C. H., Chan, M. T. V., Gelb, A. W., on behalf of the Study Group for Perioperative Stroke In China (POSIC), on behalf of the Study Group for Perioperative Stroke In China (POSIC), Wu, Yue, Sun, Guo, Ding, Wang, Tian, Mei, Yao, Tags: Review Articles Source Type: research
Current status of acute stroke management in Korea: a report on a multicenter, comprehensive acute stroke registry
There are limited data on the utilization of diagnostics and the variation of treatments at the national level in acute stroke care. Clinical Research Center for Stroke – 5th division stroke registry aimed to describe stroke statistics and quality of care in Korea and to implement quality indicators. Clinical Research Center for Stroke – 5th division registry was established in April 2008 and covers pretreatment demographics, medical and stroke severity measures, diagnostic evaluation, hyperacute revascularization, in‐hospital management, discharge disposition, quality indicators, and long‐term functional outcomes....
Source: International Journal of Stroke - November 21, 2013 Category: Neurology Authors: Beom Joon Kim, Moon‐Ku Han, Tai Hwan Park, Sang‐Soon Park, Kyung Bok Lee, Byung‐Chul Lee, Kyung‐Ho Yu, Jae Kwan Cha, Dae‐Hyun Kim, Jun Lee, Soo Joo Lee, Youngchai Ko, Jong‐Moo Park, Kyusik Kang, Yong‐Jin Cho, Keun‐Sik Hong, Ki‐Hyun Cho, Tags: Panorama Source Type: research
Factors for short-term outcomes in patients with a minor stroke: results from China National Stroke Registry
In this study, we aimed to identify which factors were associated with adverse outcomes of a minor stroke.
Methods:
The China National Stroke Registry (CNSR) is a nationwide prospective registry for patients presented to hospitals with acute cerebrovascular events between September 2007 and August 2008. The 3-month follow-up was completed in 4669 patients with a minor stroke defined as the initial neurological severity lower than 4 in the National Institutes of Health Stroke Scale (NIHSS). Multivariate model was used to determine the association between risk factors and clinical outcomes.
Results:
Of 4669 patients with a m...
Source: BMC Neurology - December 9, 2015 Category: Neurology Authors: Lingyun WuAnxin WangXianwei WangXingquan ZhaoChunxue WangLiping LiuHuaguang ZhengYongjun WangYibin CaoYilong Wangon behalf of the China National Stroke Registry investigators Source Type: research
Are Racial Disparities in Stroke Care Still Prevalent in Certified Stroke Centers?
Racial differences in stroke risk and risk factor prevalence are well established. The present study explored racial differences in the delivery of care to patients with acute stroke between Joint Commission (JC)-certified hospitals and noncertified hospitals. A retrospective chart review was conducted in patients sustaining ischemic stroke admitted to 5 JC-certified centers and 5 noncertified hospitals. Demographic data, risk factors, utilization of acute stroke therapies, and compliance with core measures were recorded. Racial disparities were investigated in the entire group as well as for JC-certified and noncertified ...
Source: Journal of Stroke and Cerebrovascular Diseases - November 14, 2011 Category: Neurology Authors: Pratik Bhattacharya, Flicia Mada, Leeza Salowich-Palm, Sabrina Hinton, Scott Millis, Sam R. Watson, Seemant Chaturvedi, Kumar Rajamani Tags: Original Articles Source Type: research
Lipoprotein(a), Ferritin, and Albumin in Acute Phase Reaction Predicts Severity and Mortality of Acute Ischemic Stroke in North Indian Patients
Background: Inflammation plays a crucial role in the pathogenesis and prognosis of stroke. We studied the behavior of lipoprotein(a) [Lp(a)], ferritin, and albumin as acute phase reactants and their roles in the severity and mortality of stroke.Methods: We recruited 100 consecutive patients with acute ischemic stroke and 120 controls. Blood samples were drawn on days 1 and 7 and at both 3 and 6 months. Stroke was classified using Trial of Org 10172 in Acute Stroke Treatment classification. Stroke severity was assessed using the National Institutes of Health Stroke Scale. Prognosis at 6 months was assessed using the modifie...
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: Baidarbhi Chakraborty, Gaurav Vishnoi, Binita Goswami, Srinivas H. Gowda, Debashish Chowdhury, Sarita Agarwal Tags: Original Articles Source Type: research
Intra‐arterial bone marrow mononuclear cells (BM‐MNCs) transplantation in acute ischemic stroke (IBIS trial): protocol of a phase II, randomized, dose‐finding, controlled multicenter trial
DiscussionThis is the first trial to explore efficacy of different doses of intra‐arterial bone marrow mononuclear cell in moderate‐to‐severe acute ischemic stroke patients. The trial is registered as NCT02178657.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Francisco Moniche, Irene Escudero, Elena Zapata‐Arriaza, María Usero‐Ruiz, María Prieto‐León, Javier Torre, Miguel‐Angel Gamero, Jose Antonio Tamayo, Juan‐José Ochoa‐Sepúlveda, José Maestre, Magdalena Carmona, Pilar Piñero, Cristina Cal Tags: Protocol Source Type: research
Spontaneous Recovery of Upper Extremity Motor Impairment After Ischemic Stroke: Implications for Stem Cell-Based Therapeutic Approaches
AbstractPreclinical studies suggest that stem cell therapy (SCT) may improve sensorimotor recovery after stroke. Upper extremity motor impairment (UEMI) is common after stroke, often entailing substantial disability. To evaluate the feasibility of post-stroke UEMI as a target for SCT, we examined a selected sample of stroke patients potentially suitable for SCT, aiming to assess the frequency and recovery of UEMI, as well as its relation to activity limitations and participation restrictions. Patients aged 20 –75 years with first-ever ischemic stroke, and National Institutes of Health Stroke Scale (NIHSS) scores 1–18,...
Source: Translational Stroke Research - February 14, 2017 Category: Neurology Source Type: research
The Stroke Hyperglycemia Insulin Network Effort (SHINE) trial protocol: a randomized, blinded, efficacy trial of standard vs. intensive hyperglycemia management in acute stroke
DiscussionThis trial will provide important novel information about preferred management of acute ischemic stroke patients with hyperglycemia. It will determine the potential benefits and risks of intensive glucose control during acute stroke.
Source: International Journal of Stroke - March 19, 2013 Category: Neurology Authors: Askiel Bruno, Valerie L. Durkalski, Christiana E. Hall, Rattan Juneja, William G. Barsan, Scott Janis, William J. Meurer, Amy Fansler, Karen C. Johnston, Tags: Protocol Source Type: research
Prevalence of Triggering Factors in Acute Stroke: Hospital-Based Observational Cross-sectional Study
Although chronic risk factors for stroke are reasonably well understood, the acute precipitants, or triggers, of stroke relatively remain understudied. Identification of particular time periods during which stroke risk is elevated could prove a valuable strategy to reduce stroke incidence through the introduction of appropriate prevention strategies during a period of vulnerability. The aim of this study was to determine the prevalence of trigger factors in acute stroke patients and to investigate the association of the presence of trigger factors with initial stroke severity at presentation (National Institutes of Health ...
Source: Journal of Stroke and Cerebrovascular Diseases - November 22, 2014 Category: Neurology Authors: Ashish Sharma, Kameshwar Prasad, M.V. Padma, Manjari Tripathi, Rohit Bhatia, Mamta Bhusan Singh, Anupriya Sharma Source Type: research
