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Neurocognitive sequelae following hippocampal and callosal lesions associated with cerebral malaria in an immune-naive adult
We report a case of a 36-year-old immune-naive Caucasian female who sustained a brain injury with neurocognitive sequelae, after a severe bout of falciparum malaria. On admission, she was unconscious, febrile, hypoglycaemic and passing black urine. She had returned from Ghana 2 days earlier. Her initial parasite count was 22%,...
Source: Postgraduate Medical Journal - October 15, 2013 Category: Journals (General) Authors: Laverse, E., Nashef, L., Brown, S. Tags: Immunology (including allergy), Drugs: infectious diseases, Travel medicine, Tropical medicine (infectious diseases), Epilepsy and seizures, Stroke, Memory disorders (psychiatry), Adult intensive care, Epidemiology, Diabetes, Metabolic disorders Images Source Type: research

ADAMTS13 and von Willebrand Factor in Thrombotic Thrombocytopenic Purpura.
Abstract Pathogenesis of thrombotic thrombocytopenic purpura (TTP) was a mystery for over half a century until the discovery of ADAMTS13. ADAMTS13 is primarily synthesized in the liver, and its main function is to cleave von Willebrand factor (VWF) anchored on the endothelial surface, in circulation, and at the sites of vascular injury. Deficiency of plasma ADAMTS13 activity (<10%) resulting from mutations of the ADAMTS13 gene or autoantibodies against ADAMTS13 causes hereditary or acquired (idiopathic) TTP. ADAMTS13 activity is usually normal or modestly reduced (>20%) in other forms of thrombotic microangi...
Source: Annual Review of Medicine - January 14, 2015 Category: Journals (General) Authors: Zheng XL Tags: Annu Rev Med Source Type: research

Epidemiological aspects of heart diseases.
Authors: Shi A, Tao Z, Wei P, Zhao J Abstract Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide. Coronary heart disease (CHD) is the main cause of mortality in heart patients following stroke, rheumatic heart disease and myocardial infarctions. Approximately 80% of individuals succumb to CVDs, due to poor living conditions in low and middle income families and malnutrition. Infectious diseases, human immunodeficiency, tuberculosis, malaria, high blood pressure or hypertension, obesity and overweight, and nutritional disorders including smoking, excessive alcohol consumption, high salt and ...
Source: Experimental and Therapeutic Medicine - September 9, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Publication date: 8–14 October 2016 Source:The Lancet, Volume 388, Issue 10053 Author(s): GBD 2015 Mortality and Causes of Death CollaboratorsHaidongWangMohsenNaghaviChristineAllenRyan MBarberZulfiqar ABhuttaAustinCarterDaniel CCaseyFiona JCharlsonAlan ZianChenMatthew MCoatesMeganCoggeshallLalitDandonaDaniel JDickerHolly EErskineAlize JFerrariChristinaFitzmauriceKyleForemanMohammad HForouzanfarMaya SFraserNancyFullmanPeter WGethingEllen MGoldbergNicholasGraetzJuanita AHaagsmaSimon IHayChantalHuynhCatherine OJohnsonNicholas JKassebaumYohannesKinfuXie RachelKulikoffMichaelKutzHmwe HKyuHeidi JLarsonJanniLeungXiaofengLiangS...
Source: The Lancet - October 6, 2016 Category: Journals (General) Source Type: research