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Total 58 results found since Jan 2013.
Dynamic reorganization of TMS-evoked activity in subcortical stroke patients
This study demonstrates that cortical activity increases dynamically in the early phases of recovery after stroke in the affected hemisphere. These findings point to TMS-evoked alpha oscillatory activity as a potential neurophysiological markers of stroke recovery and could be helpful to determine the temporal window in which neuromodulation should be potentially able to drive neuroplasticity in an effective functional direction.
Source: NeuroImage - April 14, 2018 Category: Neuroscience Source Type: research
Comparison of spatial normalization strategies of diffusion MRI data for studying motor outcome in subacute-chronic and acute stroke
Publication date: Available online 4 August 2018Source: NeuroImageAuthor(s): Eric Moulton, Romain Valabrègue, Belén Díaz, Claire Kemlin, Sara Leder, Stephane Lehéricy, Yves Samson, Charlotte RossoAbstractA common means of studying motor recovery in stroke patients is to extract Diffusion Tensor Imaging (DTI) parameters from the corticospinal tract (CST) and correlate them with clinical outcome scores. To that purpose, conducting group-level analyses through spatial normalization has become a popular approach. However, the reliability of such analyses depends on the accuracy of the particular registration strategy emplo...
Source: NeuroImage - August 8, 2018 Category: Neuroscience Source Type: research
Mapping tissue pH in an experimental model of acute stroke – Determination of graded regional tissue pH changes with non-invasive quantitative amide proton transfer MRI
Publication date: Available online 10 February 2019Source: NeuroImageAuthor(s): Enfeng Wang, Yin Wu, Jerry S. Cheung, Takahiro Igarashi, Limin Wu, Xiaoan Zhang, Phillip Zhe SunAbstractpH-weighted amide proton transfer (APT) MRI is sensitive to tissue pH change during acute ischemia, complementing conventional perfusion and diffusion stroke imaging. However, the currently used pH-weighted magnetization transfer (MT) ratio asymmetry (MTRasym) analysis is of limited pH specificity. To overcome this, MT and relaxation normalized APT (MRAPT) analysis has been developed that to homogenizes the background signal, thus providing h...
Source: NeuroImage - February 15, 2019 Category: Neuroscience Source Type: research
The PLORAS Database: A data repository for Predicting Language Outcome and Recovery After Stroke
Publication date: Available online 14 April 2015 Source:NeuroImage Author(s): Mohamed L. Seghier , Elnas Patel , Susan Prejawa , Sue Ramsden , Andre Selmer , Louise Lim , Rachel Browne , Johanna Rae , Zula Haigh , Deborah Ezekiel , Thomas M.H. Hope , Alex P. Leff , Cathy J. Price The PLORAS Database is a relational repository of anatomical and functional imaging data that has primarily been acquired from stroke survivors, along with standardized scores on a wide range of sensory, motor and cognitive abilities, demographic details and medical history. As of January 2015, we have data from 750 patients with an expected acc...
Source: NeuroImage - April 25, 2015 Category: Neuroscience Source Type: research
Characterization of a novel murine model for spontaneous hemorrhagic stroke using in vivo PET and MR multiparametric imaging
Publication date: 15 July 2017 Source:NeuroImage, Volume 155 Author(s): Salvador Castaneda Vega, Christine Weinl, Carsten Calaminus, Lisa Wang, Maren Harant, Walter Ehrlichmann, Dennis Thiele, Ursula Kohlhofer, Gerald Reischl, Johann-Martin Hempel, Ulrike Ernemann, Leticia Quintanilla Martinez, Alfred Nordheim, Bernd J. Pichler The clinical use of Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) has proven to be a strong diagnostic tool in the field of neurology. The reliability of these methods to confirm clinical diagnoses has guided preclinical research to utilize these techniques for the charact...
Source: NeuroImage - May 8, 2017 Category: Neuroscience Source Type: research
Neuroimaging of stroke recovery from aphasia – Insights into plasticity of the human language network
Publication date: Available online 23 November 2017Source: NeuroImageAuthor(s): Gesa Hartwigsen, Dorothee SaurAbstractThe role of left and right hemisphere brain regions in language recovery after stroke-induced aphasia remains controversial. Here, we summarize how neuroimaging studies increase the current understanding of functional interactions, reorganization and plasticity in the language network. We first discuss the temporal dynamics across the time course of language recovery, with a main focus on longitudinal studies from the acute to the chronic phase after stroke. These studies show that the functional contributi...
Source: NeuroImage - March 17, 2019 Category: Neuroscience Source Type: research
Re-learning to be different: Increased neural differentiation supports post-stroke language recovery
Publication date: 15 November 2019Source: NeuroImage, Volume 202Author(s): Jeremy J. Purcell, Robert W. Wiley, Brenda RappAbstractIdentifying the neural changes that support recovery of cognitive functions after a brain lesion is important to advance our understanding of human neuroplasticity, which, in turn, forms the basis for the development of effective treatments. To date, the preponderance of neuroimaging studies has focused on localizing changes in average brain activity associated with functional recovery. Here, we took a novel approach by evaluating whether cognitive recovery in chronic stroke is related to increa...
Source: NeuroImage - September 17, 2019 Category: Neuroscience Source Type: research
pH-sensitive MRI demarcates graded tissue acidification during acute stroke ― pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI
Publication date: 1 November 2016 Source:NeuroImage, Volume 141 Author(s): Yingkun Guo, Iris Yuwen Zhou, Suk-Tak Chan, Yu Wang, Emiri T. Mandeville, Takahiro Igarashi, Eng H. Lo, Xunming Ji, Phillip Zhe Sun pH-sensitive amide proton transfer (APT) MRI provides a surrogate metabolic biomarker that complements the widely-used perfusion and diffusion imaging. However, the endogenous APT MRI is often calculated using the asymmetry analysis (MTRasym), which is susceptible to an inhomogeneous shift due to concomitant semisolid magnetization transfer (MT) and nuclear overhauser (NOE) effects. Although the intact brain tissue has...
Source: NeuroImage - August 4, 2016 Category: Neuroscience Source Type: research
‘Whose atlas I use, his song I sing?’ – The impact of anatomical atlases on fiber tract contributions to cognitive deficits after stroke
Publication date: December 2017 Source:NeuroImage, Volume 163 Author(s): Bianca de Haan, Hans-Otto Karnath Nowadays, different anatomical atlases exist for the anatomical interpretation of the results from neuroimaging and lesion analysis studies that investigate the contribution of white matter fiber tract integrity to cognitive (dys)function. A major problem with the use of different atlases in different studies, however, is that the anatomical interpretation of neuroimaging and lesion analysis results might vary as a function of the atlas used. This issue might be particularly prominent in studies that investigate the ...
Source: NeuroImage - October 4, 2017 Category: Neuroscience Source Type: research
Associations between low circulatory low-density lipoprotein cholesterol level and brain health in non-stroke non-demented subjects
In conclusion, the role of circulatory LDL-C level and its interactive effect with hypertension on brain health are firstly demonstrated. A low circulatory LDL-C level was associated with reduced regional brain GMVs in hypertensive but not normotensive subjects. In addition, there seems a combined detrimental-effect of low circulatory LDL-C levels with hypertension on posterior cingulate GMV, WMH, and verbal memory.
Source: NeuroImage - July 25, 2018 Category: Neuroscience Source Type: research
Estimating effects of graded white matter damage and binary tract disconnection on post-stroke language impairment
Publication date: Available online 14 January 2019Source: NeuroImageAuthor(s): Jason Geller, Melissa Thye, Daniel MirmanAbstractDespite the critical importance of close replications in strengthening and advancing scientific knowledge, there are inherent challenges to conducting replications of lesion-based studies. In the present study, we conducted a close conceptual replication of a study (i.e., Hope et al., 2016) that found that fluency and naming scores in post-stoke aphasia were more strongly associated with a binary measure of structural white matter integrity (tract disconnection) than a graded measure (lesion load)...
Source: NeuroImage - January 15, 2019 Category: Neuroscience Source Type: research
A systematic optimization of 19F MR image acquisition to detect macrophage invasion into an ECM hydrogel implanted in the stroke-damage brain
Publication date: Available online 10 August 2019Source: NeuroImageAuthor(s): Harmanvir Ghuman, T. Kevin Hitchens, Michel ModoAbstract19F-MR imaging of perfluorocarbon (PFC)-labeled macrophages can provide a unique insight into their participation and spatio-temporal dynamics of inflammatory events, such as the biodegradation of an extracellular matrix (ECM) hydrogel implanted into a stroke cavity. To determine the most efficient acquisition strategy for 19F-MR imaging, five commonly used sequences were optimized using a design of experiment (DoE) approach and compared based on their signal-to-noise ratio (SNR). The fast i...
Source: NeuroImage - August 12, 2019 Category: Neuroscience Source Type: research
Damage to the shortest structural paths between brain regions is associated with disruptions of resting-state functional connectivity after stroke
Publication date: Available online 30 January 2020Source: NeuroImageAuthor(s): Joseph C. Griffis, Nicholas V. Metcalf, Maurizio Corbetta, Gordon L. ShulmanAbstractFocal brain lesions disrupt resting-state functional connectivity, but the underlying structural mechanisms are unclear. Here, we examined the direct and indirect effects of structural disconnections on resting-state functional connectivity in a large sample of sub-acute stroke patients with heterogeneous brain lesions. We estimated the impact of each patient's lesion on the structural connectome by embedding the lesion in a diffusion MRI streamline tractography ...
Source: NeuroImage - January 31, 2020 Category: Neuroscience Source Type: research
Functional and anatomical dissociation between the orthographic lexicon and the orthographic buffer revealed in reading and writing Chinese characters by fMRI
Publication date: 1 April 2016 Source:NeuroImage, Volume 129 Author(s): Hsiang-Yu Chen, Erik C. Chang, Sinead H.Y. Chen, Yi-Chen Lin, Denise H. Wu The contribution of orthographic representations to reading and writing has been intensively investigated in the literature. However, the distinction between neuronal correlates of the orthographic lexicon and the orthographic (graphemic) buffer has rarely been examined in alphabetic languages and never been explored in non-alphabetic languages. To determine whether the neural networks associated with the orthographic lexicon and buffer of logographic materials are compar...
Source: NeuroImage - February 8, 2016 Category: Neuroscience Source Type: research
Enhancing sensitivity of pH-weighted MRI with combination of amide and guanidyl CEST
Publication date: 15 August 2017 Source:NeuroImage, Volume 157 Author(s): Tao Jin, Ping Wang, T. Kevin Hitchens, Seong-Gi Kim Amide-proton-transfer weighted (APTw) MRI has emerged as a non-invasive pH-weighted imaging technique for studies of several diseases such as ischemic stroke. However, its pH-sensitivity is relatively low, limiting its capability to detect small pH changes. In this work, computer simulations, protamine phantom experiments, and in vivo gas challenge and experimental stroke in rats showed that, with judicious selection of the saturation pulse power, the amide-CEST at 3.6ppm and guanidyl-CEST signals ...
Source: NeuroImage - June 20, 2017 Category: Neuroscience Source Type: research
