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Total 58 results found since Jan 2013.
Tracer kinetic modelling for DCE-MRI quantification of subtle blood–brain barrier permeability
Publication date: 15 January 2016 Source:NeuroImage, Volume 125 Author(s): Anna K. Heye, Michael J. Thrippleton, Paul A. Armitage, Maria del C. Valdés Hernández, Stephen D. Makin, Andreas Glatz, Eleni Sakka, Joanna M. Wardlaw There is evidence that subtle breakdown of the blood–brain barrier (BBB) is a pathophysiological component of several diseases, including cerebral small vessel disease and some dementias. Dynamic contrast-enhanced MRI (DCE-MRI) combined with tracer kinetic modelling is widely used for assessing permeability and perfusion in brain tumours and body tissues where contrast agents readily acc...
Source: NeuroImage - November 12, 2015 Category: Neuroscience Source Type: research
Brain–robot interface driven plasticity: Distributed modulation of corticospinal excitability
In conclusion, the BRI intervention induced a complex pattern of modulated corticospinal excitability, which may boost subsequent motor learning during physiotherapy. Graphical abstract
Source: NeuroImage - November 12, 2015 Category: Neuroscience Source Type: research
Computational modelling of movement-related beta-oscillatory dynamics in human motor cortex
Publication date: June 2016 Source:NeuroImage, Volume 133 Author(s): Mrudul B. Bhatt, Stephanie Bowen, Holly E. Rossiter, Joshua Dupont-Hadwen, Rosalyn J. Moran, Karl J. Friston, Nick S. Ward Oscillatory activity in the beta range, in human primary motor cortex (M1), shows interesting dynamics that are tied to behaviour and change systematically in disease. To investigate the pathophysiology underlying these changes, we must first understand how changes in beta activity are caused in healthy subjects. We therefore adapted a canonical (repeatable) microcircuit model used in dynamic causal modelling (DCM) previously...
Source: NeuroImage - March 28, 2016 Category: Neuroscience Source Type: research
Clinical Vascular Imaging in the Brain at 7 T
Publication date: Available online 18 November 2016 Source:NeuroImage Author(s): Laurens JL De Cocker, Arjen Lindenholz, Jaco JM Zwanenburg, Anja van der Kolk, Maarten Zwartbol, Peter Luijten, Jeroen Hendrikse Stroke and related cerebrovascular diseases are a major cause of mortality and disability. Even at standard-field-strengths (1.5T), MRI is by far the most sensitive imaging technique to detect acute brain infarctions and to characterize incidental cerebrovascular lesions, such as white matter hyperintensities, lacunes and microbleeds. Arterial time-of-flight (TOF) MR angiography (MRA) can depict luminal narrowing or...
Source: NeuroImage - November 17, 2016 Category: Neuroscience Source Type: research
EEG neural correlates of goal-directed movement intention
Publication date: 1 April 2017 Source:NeuroImage, Volume 149 Author(s): Joana Pereira, Patrick Ofner, Andreas Schwarz, Andreea Ioana Sburlea, Gernot R. Müller-Putz Using low-frequency time-domain electroencephalographic (EEG) signals we show, for the same type of upper limb movement, that goal-directed movements have different neural correlates than movements without a particular goal. In a reach-and-touch task, we explored the differences in the movement-related cortical potentials (MRCPs) between goal-directed and non-goal-directed movements. We evaluated if the detection of movement intention was influenced by the goa...
Source: NeuroImage - February 2, 2017 Category: Neuroscience Source Type: research
Parallel changes in cortical neuron biochemistry and motor function in protein-energy malnourished adult rats
Publication date: 1 April 2017 Source:NeuroImage, Volume 149 Author(s): Mariam Alaverdashvili, Mark J. Hackett, Sally Caine, Phyllis G. Paterson While protein-energy malnutrition in the adult has been reported to induce motor abnormalities and exaggerate motor deficits caused by stroke, it is not known if alterations in mature cortical neurons contribute to the functional deficits. Therefore, we explored if PEM in adult rats provoked changes in the biochemical profile of neurons in the forelimb and hindlimb regions of the motor cortex. Fourier transform infrared spectroscopic imaging using a synchrotron generated light so...
Source: NeuroImage - February 10, 2017 Category: Neuroscience Source Type: research
Using multi-level Bayesian lesion-symptom mapping to probe the body-part-specificity of gesture imitation skills
Publication date: 1 November 2017 Source:NeuroImage, Volume 161 Author(s): Elisabeth I.S. Achilles, Peter H. Weiss, Gereon R. Fink, Ellen Binder, Cathy J. Price, Thomas M.H. Hope Past attempts to identify the neural substrates of hand and finger imitation skills in the left hemisphere of the brain have yielded inconsistent results. Here, we analyse those associations in a large sample of 257 left hemisphere stroke patients. By introducing novel Bayesian methods, we characterise lesion symptom associations at three levels: the voxel-level, the single-region level (using anatomically defined regions), and the region-pair le...
Source: NeuroImage - August 22, 2017 Category: Neuroscience Source Type: research
Sensorimotor impairment of speech auditory feedback processing in aphasia
Publication date: 15 January 2018 Source:NeuroImage, Volume 165 Author(s): Roozbeh Behroozmand, Lorelei Phillip, Karim Johari, Leonardo Bonilha, Chris Rorden, Gregory Hickok, Julius Fridriksson We investigated the brain network involved in speech sensorimotor processing by studying patients with post-stroke aphasia using an altered auditory feedback (AAF) paradigm. We combined lesion-symptom-mapping analysis and behavioral testing to examine the pervasiveness of speech sensorimotor deficits and their relationship with cortical damage. Sixteen participants with aphasia and sixteen neurologically intact individuals complete...
Source: NeuroImage - October 16, 2017 Category: Neuroscience Source Type: research
Long-term optical imaging of neurovascular coupling in mouse cortex using GCaMP6f and intrinsic hemodynamic signals
Publication date: 15 January 2018 Source:NeuroImage, Volume 165 Author(s): Xiaochun Gu, Wei Chen, Jiang You, Alan P. Koretsky, N.D. Volkow, Yingtian Pan, Congwu Du Cerebral hemodynamics are modulated in response to changes in neuronal activity, a process termed neurovascular coupling (NVC), which can be disrupted by neuropsychiatric diseases (e.g., stroke, Alzheimer's disease). Thus, there is growing interest to image long-term NVC dynamics with high spatiotemporal resolutions. Here, by combining the use of a genetically-encoded calcium indicator with optical techniques, we develop a longitudinal multimodal optical imagin...
Source: NeuroImage - November 6, 2017 Category: Neuroscience Source Type: research
Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia
Conclusions In a community-dwelling non-demented population, we describe patterns of association between hippocampal subregions with cognition and risk of dementia. Specifically, the subiculum was associated with both poorer cognition and higher risk of dementia.
Source: NeuroImage - May 26, 2018 Category: Neuroscience Source Type: research
Reproducibility of corticokinematic coherence
Publication date: Available online 30 June 2018Source: NeuroImageAuthor(s): Harri Piitulainen, Mia Illman, Kristina Laaksonen, Veikko Jousmäki, Nina ForssAbstractCorticokinematic coherence (CKC) between limb kinematics and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. However, it is unclear whether strength of CKC is reproducible across measurement sessions. We thus examined reproducibility of CKC in a follow-up study.Thirteen healthy right-handed volunteers (7 females, 21.7 ± 4.3 yrs) were measured using MEG in two separate sessions 12.6 ± 1.3 months apart. Th...
Source: NeuroImage - July 5, 2018 Category: Neuroscience Source Type: research
Variational Bayesian inversion for hierarchical unsupervised generative embedding (HUGE)
Publication date: Available online 28 June 2018Source: NeuroImageAuthor(s): Yu Yao, Sudhir S. Raman, Michael Schiek, Alex Leff, Stefan Frässle, Klaas E. StephanAbstractA recently introduced hierarchical generative model unified the inference of effective connectivity in individual subjects and the unsupervised identification of subgroups defined by connectivity patterns. This hierarchical unsupervised generative embedding (HUGE) approach combined a hierarchical formulation of dynamic causal modelling (DCM) for fMRI with Gaussian mixture models and relied on Markov chain Monte Carlo (MCMC) sampling for inference. While wel...
Source: NeuroImage - July 5, 2018 Category: Neuroscience Source Type: research
Reproducibility of corticokinematic coherence
Publication date: 1 October 2018Source: NeuroImage, Volume 179Author(s): Harri Piitulainen, Mia Illman, Kristina Laaksonen, Veikko Jousmäki, Nina ForssAbstractCorticokinematic coherence (CKC) between limb kinematics and magnetoencephalographic (MEG) signals reflects cortical processing of proprioceptive afference. However, it is unclear whether strength of CKC is reproducible across measurement sessions. We thus examined reproducibility of CKC in a follow-up study.Thirteen healthy right-handed volunteers (7 females, 21.7 ± 4.3 yrs) were measured using MEG in two separate sessions 12.6 ± 1.3 months apart. The p...
Source: NeuroImage - July 10, 2018 Category: Neuroscience Source Type: research
Variational Bayesian inversion for hierarchical unsupervised generative embedding (HUGE)
Publication date: 1 October 2018Source: NeuroImage, Volume 179Author(s): Yu Yao, Sudhir S. Raman, Michael Schiek, Alex Leff, Stefan Frässle, Klaas E. StephanAbstractA recently introduced hierarchical generative model unified the inference of effective connectivity in individual subjects and the unsupervised identification of subgroups defined by connectivity patterns. This hierarchical unsupervised generative embedding (HUGE) approach combined a hierarchical formulation of dynamic causal modelling (DCM) for fMRI with Gaussian mixture models and relied on Markov chain Monte Carlo (MCMC) sampling for inference. While well s...
Source: NeuroImage - July 10, 2018 Category: Neuroscience Source Type: research
Transcranial direct current stimulation (tDCS) facilitates verb learning by altering effective connectivity in the healthy brain
Publication date: Available online 17 July 2018Source: NeuroImageAuthor(s): Valentina Fiori, Lisa Kunz, Philipp Kuhnke, Paola Marangolo, Gesa HartwigsenAbstractRecent studies have shown that the left inferior frontal gyrus (IFG) plays a key role in language learning. Facilitatory stimulation over this region by means of anodal transcranial direct current stimulation (tDCS) can modulate linguistic abilities in healthy individuals and improve language performance in patients with post-stroke aphasia. Neuroimaging studies in healthy participants have suggested that anodal tDCS decreases task-related activity at the stimulated...
Source: NeuroImage - July 18, 2018 Category: Neuroscience Source Type: research
